6-Hydroxy-chroman-4-one

Product Name: 6-Hydroxy-chroman-4-one
CAS No.: 80096-64-6
Chemical Name: 6-Hydroxy-chroman-4-one
Synonyms: 6-Hydroxy-4-chromanone;6-HYDROXY-CHROMAN-4-ONE;6-hydroxy-2,3-dihydrochroMen-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-6-hydroxy-
CBNumber: CB41010905
Molecular Formula: C9H8O3
Formula Weight: 164.16
MOL File: 80096-64-6.mol

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6-Hydroxy-chroman-4-one Property

Melting point:: 129-131 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
Boiling point:: 372.4±42.0 °C(Predicted)
Density: 1.343±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 9.58±0.20(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C9H8O3/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-2,5,10H,3-4H2
InChIKey: HTKPIKIGEYFNBY-UHFFFAOYSA-N
SMILES: C1OC2=CC=C(O)C=C2C(=O)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 2500AC
Product name: 6-Hydroxy-chroman-4-one
Packaging: 100mg
Price: $136
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1043792
Product name: 6-HYDROXY-CHROMAN-4-ONE
Purity: 95.00%
Packaging: 5MG
Price: $504.91
Updated: 2021/12/16

Chemenu

Product number: CM133551
Product name: 6-hydroxychroman-4-one
Purity: 98%
Packaging: 1g
Price: $239
Updated: 2021/12/16

Crysdot

Product number: CD11054874
Product name: 6-Hydroxy-chroman-4-one
Purity: 98%
Packaging: 1g
Price: $253
Updated: 2021/12/16

Alichem

Product number: 80096646
Product name: 6-Hydroxy-chroman-4-one
Packaging: 1g
Price: $255
Updated: 2021/12/16

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6-Hydroxy-chroman-4-one Chemical Properties,Usage,Production

Uses

6-Hydroxy-chroman-4-one is used in the preparation of novels parasite transmission blocking antimalarials targeting male gametes

Synthesis

5802-17-5

80096-64-6

(3) Preparation of 2,3-dihydro-6-hydroxychromen-4-one: 6-methoxychromen-dihydropyran-4-one (2.9 g, 0.0163 mol) was sequentially added to a mixed solution of glacial acetic acid (20 mL) and HBr (>40%, 20 mL), stirred and refluxed for 1 h. The reaction solution was then extracted with ethyl acetate. Upon completion of the reaction, the pH of the reaction solution was adjusted to 10-11 with KOH solution, and then the pH of the aqueous layer was adjusted to 2-3 with concentrated hydrochloric acid.Subsequently, the aqueous layer was extracted with ethyl acetate, and the organic layers were combined and dried with anhydrous Na2SO4. The dried organic layer was cooled and a black solid was precipitated. The solid was recrystallized with ethyl acetate to give 2.17 g of bright yellow crystals with a melting point of 142-144 °C and a yield of 81.2%.

References

[1] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 18, p. 2773 - 2778
[2] Patent: US5641789, 1997, A
[3] Patent: US2008/103307, 2008, A1. Location in patent: Page/Page column 17
[4] Patent: US5322847, 1994, A
[5] Patent: EP641792, 1995, A1

6-Hydroxy-chroman-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Hydroxy-chroman-4-one Suppliers

China 52 India 1 United States 4 Global 57

Shandong Xingzhi Biological Medicine Co. LTD

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Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
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Shanghai Sunway Pharmaceutical Technology Co., Ltd

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Guangzhou Isun Pharmaceutical Co., Ltd

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Bide Pharmatech Ltd.

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Suzhou yacoo science co.,Ltd

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Shanghai Tombiopharma Chemical Co. Ltd.

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LABTER PHARMATECH(BEIJING) CO.,LTD

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Fax: 010-56330744
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Country: China
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6-hydroxy-2,3-dihydrochroMen-4-one

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6-Hydroxy-4-chromanone

6-HYDROXY-CHROMAN-4-ONE

80096-64-6