ChemicalBook > CAS DataBase List > 6-Hydroxy-chroman-4-one

6-Hydroxy-chroman-4-one

Product Name
6-Hydroxy-chroman-4-one
CAS No.
80096-64-6
Chemical Name
6-Hydroxy-chroman-4-one
Synonyms
6-Hydroxy-4-chromanone;6-HYDROXY-CHROMAN-4-ONE;6-hydroxy-2,3-dihydrochroMen-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-6-hydroxy-
CBNumber
CB41010905
Molecular Formula
C9H8O3
Formula Weight
164.16
MOL File
80096-64-6.mol
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6-Hydroxy-chroman-4-one Property

Melting point:
129-131 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
Boiling point:
372.4±42.0 °C(Predicted)
Density 
1.343±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
9.58±0.20(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C9H8O3/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-2,5,10H,3-4H2
InChIKey
HTKPIKIGEYFNBY-UHFFFAOYSA-N
SMILES
C1OC2=CC=C(O)C=C2C(=O)C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
2500AC
Product name
6-Hydroxy-chroman-4-one
Packaging
100mg
Price
$136
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM1043792
Product name
6-HYDROXY-CHROMAN-4-ONE
Purity
95.00%
Packaging
5MG
Price
$504.91
Updated
2021/12/16
Chemenu
Product number
CM133551
Product name
6-hydroxychroman-4-one
Purity
98%
Packaging
1g
Price
$239
Updated
2021/12/16
Crysdot
Product number
CD11054874
Product name
6-Hydroxy-chroman-4-one
Purity
98%
Packaging
1g
Price
$253
Updated
2021/12/16
Alichem
Product number
80096646
Product name
6-Hydroxy-chroman-4-one
Packaging
1g
Price
$255
Updated
2021/12/16
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6-Hydroxy-chroman-4-one Chemical Properties,Usage,Production

Uses

6-Hydroxy-chroman-4-one is used in the preparation of novels parasite transmission blocking antimalarials targeting male gametes

Synthesis

5802-17-5

80096-64-6

(3) Preparation of 2,3-dihydro-6-hydroxychromen-4-one: 6-methoxychromen-dihydropyran-4-one (2.9 g, 0.0163 mol) was sequentially added to a mixed solution of glacial acetic acid (20 mL) and HBr (>40%, 20 mL), stirred and refluxed for 1 h. The reaction solution was then extracted with ethyl acetate. Upon completion of the reaction, the pH of the reaction solution was adjusted to 10-11 with KOH solution, and then the pH of the aqueous layer was adjusted to 2-3 with concentrated hydrochloric acid.Subsequently, the aqueous layer was extracted with ethyl acetate, and the organic layers were combined and dried with anhydrous Na2SO4. The dried organic layer was cooled and a black solid was precipitated. The solid was recrystallized with ethyl acetate to give 2.17 g of bright yellow crystals with a melting point of 142-144 °C and a yield of 81.2%.

References

[1] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 18, p. 2773 - 2778
[2] Patent: US5641789, 1997, A
[3] Patent: US2008/103307, 2008, A1. Location in patent: Page/Page column 17
[4] Patent: US5322847, 1994, A
[5] Patent: EP641792, 1995, A1

6-Hydroxy-chroman-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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80096-64-6, 6-Hydroxy-chroman-4-oneRelated Search:

4',5,7,8-TETRAHYDROXYFLAVANONE 6-Methoxy-4-chromanone 6-METHOXYFLAVANONE 6-HYDROXYFLAVANONE 2,2-DIMETHYL-6-HYDROXY-4-CHROMANONE 6,7-DIMETHOXY-2,2-DIMETHYL-4-CHLOROMANONE 1'-benzyl-6-methoxyspiro[chroman-2,4'-piperidin]-4-one 6-Hydroxy-chroman-4-one 5,9,10-TRIMETHOXY-3,3-DIMETHYL-13,13A-DIHYDRO-3H,7AH-PYRANO[2,3-C:6,5-F']DICHROMEN-7-ONE 6,2'-DIHYDROXYFLAVANONE 6,2'',4''-TRIMETHOXYFLAVANONE 6,3'-DIMETHOXYFLAVANONE BUTTPARK 35\07-36 6,4'-DIMETHOXYFLAVANONE 6-HYDROXYSUMATROL 6-METHOXY-2,2-BIS(TRIFLUOROMETHYL)CHROMANE-4-ONE (E)-2,3-Dihydro-3-((3,4-dimethoxyphenyl)methylene)-6-methoxy-4H-1-benz opyran-4-one 3',4',5,6,7,8-HEXAMETHOXYFLAVANONE

  • 6-hydroxy-2,3-dihydrochroMen-4-one
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-6-hydroxy-
  • 6-Hydroxy-4-chromanone
  • 6-HYDROXY-CHROMAN-4-ONE
  • 80096-64-6