Minodronic acid
- Product Name
- Minodronic acid
- CAS No.
- 180064-38-4
- Chemical Name
- Minodronic acid
- Synonyms
- BPH 261;Bonoteo;Recalbon;ONO 5920;Nsc725590;Minodronicaci;Mino phosphate;Minodronic Acid;Minodronic acid (anhydrous);(127657-42-5) minodronic acid
- CBNumber
- CB41011573
- Molecular Formula
- C9H12N2O7P2
- Formula Weight
- 322.15
- MOL File
- 180064-38-4.mol
Minodronic acid Property
- Density
- 1.97±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Aqueous Base (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 1.48±0.10(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M344900
- Product name
- MinodronicAcid
- Packaging
- 10mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- M344900
- Product name
- MinodronicAcid
- Packaging
- 250mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 100293
- Product name
- (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $348
- Updated
- 2021/12/16
- Product number
- API0009219
- Product name
- MINODRONATE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $225.75
- Updated
- 2021/12/16
- Product number
- 100293
- Product name
- (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $226
- Updated
- 2021/12/16
Minodronic acid Chemical Properties,Usage,Production
Description
Minodronic acid hydrate, a third-generation bisphosphonate, was
approved and launched in Japan for the oral treatment of
osteoporosis. Osteoporosis is a skeletal disorder characterized by low bone mass and structural deterioration of bone tissue resulting in bone
fragility and increased susceptibility to fractures, particularly of the hip,
spine, and wrist. It is the most common type of metabolic bone disease
and a major health concern affecting 200 million women worldwide.
Minodronic acid is the newest nitrogen-containing bisphosphonate to reach the market. In vitro, it inhibits
recombinant human FPP synthase activity with similar potency as zoledronic acid (IC50 = 3 nM for both agents).
The most common adverse events associated with minodronic acid included stomach and abdominal discomfort, abdominal pain, decrease in blood calcium level, and gastritis. The chemical synthesis of minodronic acid starts with a condensation reaction of 2-aminopyridine with ethyl 4-bromo-3-oxobutyrate by means of sodium bicarbonate to produce 2-(imidazo[1,2-a]pyridin-3-yl)acetic acid ethyl ester, which is hydrolyzed to the corresponding carboxylic acid with potassium hydroxide. Treatment of the carboxylic acid intermediate with phosphorus acid and phosphorus trichloride followed by hydrolysis with hydrochloric acid gives minodronic acid.
Originator
Astellas Pharma (Japan)
Uses
Minodronic acid is developed for osteoporosis treatment.
brand name
Recalbon, Bonoteo
Minodronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Minodronic acid Suppliers
- Tel
- 0760-86925768 18824993998
- Fax
- 0760-86925770
- seas168@126.com
- Country
- China
- ProdList
- 60
- Advantage
- 58
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 5047
- Advantage
- 50
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12335
- Advantage
- 58
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1493
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
View Lastest Price from Minodronic acid manufacturers
- Product
- Minodronic acid 180064-38-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-06-06
- Product
- Minodronic acid 180064-38-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-07
- Product
- Minodronic acid 180064-38-4
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-15