Dianhydrogalactitol
- Product Name
- Dianhydrogalactitol
- CAS No.
- 23261-20-3
- Chemical Name
- Dianhydrogalactitol
- Synonyms
- 1,2:5,6-Dianhydrogalactitol;VAL-083;VAL083;VAL 083;NSC-132313;Dulcitol diepoxide;Dianhydrodulcitolum;Dianhydrogalactitol;5,6-Diepoxydulcitol;1,2:5,6-Diepoxydulcitol
- CBNumber
- CB41016710
- Molecular Formula
- C6H10O4
- Formula Weight
- 146.14
- MOL File
- 23261-20-3.mol
Dianhydrogalactitol Property
- Melting point:
- 96.5-98.5 °C
- Boiling point:
- 185.74°C (rough estimate)
- Density
- 1.567
- refractive index
- 1.4310 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 13.53±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- SML3333
- Product name
- Dianhydrogalactitol
- Purity
- ≥95% (HPLC)
- Packaging
- 5MG
- Price
- $88.6
- Updated
- 2024/03/01
- Product number
- SML3333
- Product name
- Dianhydrogalactitol
- Purity
- ≥95% (HPLC)
- Packaging
- 25MG
- Price
- $357
- Updated
- 2024/03/01
- Product number
- D720515
- Product name
- DulcitolDiepoxide
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 293253
- Product name
- 1,2:5,6-Dianhydrogalactitol
- Packaging
- 100mg
- Price
- $602
- Updated
- 2021/12/16
- Product number
- CS-1358
- Product name
- VAL-083
- Packaging
- 5mg
- Price
- $220
- Updated
- 2021/12/16
Dianhydrogalactitol Chemical Properties,Usage,Production
Uses
Dulcitol Diepoxide is a cytostatic drug. Dulcitol Diepoxide can be used for treatment of leukemia, lung cancer, multiple myeloma, and nasopharyngeal carcinoma.
Biological Activity
val-083 is a bi-functional alkylating agent, with potential antitumor activity.val-083 can cross the blood brain barrier and appears to be selective for tumor cells. val-083 alkylates and crosslinks dna which ultimately inhibit the proliferation of cancer cells. val-083 does not show cross-resistance to other conventional chemotherapeutic agents. the half-life of val-083 in the brain is long. val-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.
in vitro
VAL-083 is an alkylating agent that creates N7 methylation on DNA. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h.
in vivo
VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. It (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl.
target
DNA
References
http://www. delmarpharma.com/product_development_programs/val083/
Dianhydrogalactitol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dianhydrogalactitol manufacturers
- Product
- Dianhydrodulcitol
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-05