ChemicalBook > CAS DataBase List > 3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
- Product Name
- 3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
- CAS No.
- 161187-57-1
- Chemical Name
- 3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
- Synonyms
- αGlucosidaseIN23;α-Glucosidase-IN-23;α-Glucosidase-IN-23, 10 mM in DMSO;3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
- CBNumber
- CB410220715
- Molecular Formula
- C20H23NO6
- Formula Weight
- 373.4
- MOL File
- 161187-57-1.mol
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3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Property
- Boiling point:
- 481.5±45.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- pka
- 3.06±0.70(Predicted)
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3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Chemical Properties,Usage,Production
Uses
α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1].
in vivo
α-Glucosidase-IN-23 (oral; 0.2 mmol/kg/day) only inhibits a-glucosidase in mice[1].
| Animal Model: | Mice[1] | ||||||||
| Dosage: | 0.2 mmol/kg | ||||||||
| Administration: | Oral; 0.2 mmol/kg/day | ||||||||
| Result: |
|
References
[1] Peter A Sidhom, et al. Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species. J Med Chem. 2023 Jan 12;66(1):991-1010. DOI:10.1021/acs.jmedchem.2c01818
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Suppliers
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