5,7-DIBROMO INDOLE

Product Name: 5,7-DIBROMO INDOLE
CAS No.: 36132-08-8
Chemical Name: 5,7-DIBROMO INDOLE
Synonyms: 5,7-DIBROMO INDOLE;5,7-Dibromoindole 97%;1H-Indole, 5,7-dibromo-
CBNumber: CB4102430
Molecular Formula: C8H5Br2N
Formula Weight: 274.94
MOL File: 36132-08-8.mol

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5,7-DIBROMO INDOLE Property

Melting point:: 67-72°C
Boiling point:: 368.5±22.0 °C(Predicted)
Density: 2.048±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.37±0.30(Predicted)
form: powder
Appearance: White to off-white Solid

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Safety

Hazard Codes: T
Risk Statements: 25-37/38-41
Safety Statements: 26-39-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 708798
Product name: 5,7-Dibromoindole
Purity: 97%
Packaging: 1g
Price: $121.94
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: HCH0066678
Product name: 5,7-DIBROMOINDOLE
Purity: 95.00%
Packaging: 1MG
Price: $586.97
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0066678
Product name: 5,7-DIBROMOINDOLE
Purity: 95.00%
Packaging: 10MG
Price: $618.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0066678
Product name: 5,7-DIBROMOINDOLE
Purity: 95.00%
Packaging: 5MG
Price: $623.82
Updated: 2021/12/16

AK Scientific

Product number: 4555AB
Product name: 5,7-Dibromo-1H-indole
Packaging: 5g
Price: $890
Updated: 2021/12/16

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5,7-DIBROMO INDOLE Chemical Properties,Usage,Production

Uses

5,7-Dibromo-1H-indole is an indole compound with two bromine atoms as substituents on the benzene ring. 5,7-Dibromo-1H-indole can participate in metalation reactions, the most common of which is lithiation. Other metals used in direct metalation or transmetalation of indoles include magnesium, zinc, tin, and boron. The structure is also known for directed metalation of nitrogen functional groups, directed orthorhombic metalation of substituents other than nitrogen, and halogen metal exchange.

Synthesis

51686-78-3

1826-67-1

36132-08-8

Vinylmagnesium bromide (21.0 g, 160 mmol) was slowly added to a solution of 2,4-dibromo-1-nitrobenzene (15.0 g, 53.3 mmol) in tetrahydrofuran (THF, 150 mL) at -40°C and the reaction was stirred for 30 min maintaining the temperature at -40°C. Upon completion of the reaction, the reaction mixture was carefully poured into saturated ammonium chloride (NH4Cl, 300 mL) solution and extracted with ethyl acetate (EtOAc, 3 x 300 mL). The organic layers were combined, washed with saturated brine (200 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (100-200 mesh, eluent 0 to 8% ethyl acetate in hexane solution) to afford 5,7-dibromo-1H-indole (5.90 g, 41% yield) as a brown solid.1H NMR (400 MHz, DMSO-d6) δ 6.56 (d, J=2.4 Hz, 1H), 7.43-7.52 (m 2H), 7.78 (s, 1H), 11.57 (brs, 1H).

References

[1] Patent: WO2017/20010, 2017, A1. Location in patent: Paragraph 0211

5,7-DIBROMO INDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-DIBROMO INDOLE Suppliers

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36132-08-8, 5,7-DIBROMO INDOLERelated Search:

Origanum oil 1,3,6-TRIBROMO-9-(OXIRAN-2-YLMETHYL)-9H-CARBAZOLE SULFURIC ACID COMPOUND WITH 3-(5,7-DIBROMO-1H-INDOL-3-YL)PROPYLAMINE (1:1) 5,7-DIBROMO INDOLE 1-(4-[2-HYDROXY-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPYL]PIPERAZINO)-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPAN-2-OL DIHYDROCHLORIDE 2-(5,7-DIBROMO-2-METHYL-1H-INDOL-3-YL)ETHANAMINE HYDROCHLORIDE

5,7-DIBROMO INDOLE

5,7-Dibromoindole 97%

1H-Indole, 5,7-dibromo-

36132-08-8