5,7-DIBROMO INDOLE
- Product Name
- 5,7-DIBROMO INDOLE
- CAS No.
- 36132-08-8
- Chemical Name
- 5,7-DIBROMO INDOLE
- Synonyms
- 5,7-DIBROMO INDOLE;5,7-Dibromoindole 97%;1H-Indole, 5,7-dibromo-
- CBNumber
- CB4102430
- Molecular Formula
- C8H5Br2N
- Formula Weight
- 274.94
- MOL File
- 36132-08-8.mol
5,7-DIBROMO INDOLE Property
- Melting point:
- 67-72°C
- Boiling point:
- 368.5±22.0 °C(Predicted)
- Density
- 2.048±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.37±0.30(Predicted)
- form
- powder
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- T
- Risk Statements
- 25-37/38-41
- Safety Statements
- 26-39-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 708798
- Product name
- 5,7-Dibromoindole
- Purity
- 97%
- Packaging
- 1g
- Price
- $121.94
- Updated
- 2025/07/31
- Product number
- HCH0066678
- Product name
- 5,7-DIBROMOINDOLE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $586.97
- Updated
- 2021/12/16
- Product number
- HCH0066678
- Product name
- 5,7-DIBROMOINDOLE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $618.5
- Updated
- 2021/12/16
- Product number
- HCH0066678
- Product name
- 5,7-DIBROMOINDOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $623.82
- Updated
- 2021/12/16
- Product number
- 4555AB
- Product name
- 5,7-Dibromo-1H-indole
- Packaging
- 5g
- Price
- $890
- Updated
- 2021/12/16
5,7-DIBROMO INDOLE Chemical Properties,Usage,Production
Uses
5,7-Dibromo-1H-indole is an indole compound with two bromine atoms as substituents on the benzene ring. 5,7-Dibromo-1H-indole can participate in metalation reactions, the most common of which is lithiation. Other metals used in direct metalation or transmetalation of indoles include magnesium, zinc, tin, and boron. The structure is also known for directed metalation of nitrogen functional groups, directed orthorhombic metalation of substituents other than nitrogen, and halogen metal exchange.
Synthesis
51686-78-3
1826-67-1
36132-08-8
Vinylmagnesium bromide (21.0 g, 160 mmol) was slowly added to a solution of 2,4-dibromo-1-nitrobenzene (15.0 g, 53.3 mmol) in tetrahydrofuran (THF, 150 mL) at -40°C and the reaction was stirred for 30 min maintaining the temperature at -40°C. Upon completion of the reaction, the reaction mixture was carefully poured into saturated ammonium chloride (NH4Cl, 300 mL) solution and extracted with ethyl acetate (EtOAc, 3 x 300 mL). The organic layers were combined, washed with saturated brine (200 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (100-200 mesh, eluent 0 to 8% ethyl acetate in hexane solution) to afford 5,7-dibromo-1H-indole (5.90 g, 41% yield) as a brown solid.1H NMR (400 MHz, DMSO-d6) δ 6.56 (d, J=2.4 Hz, 1H), 7.43-7.52 (m 2H), 7.78 (s, 1H), 11.57 (brs, 1H).
References
[1] Patent: WO2017/20010, 2017, A1. Location in patent: Paragraph 0211
5,7-DIBROMO INDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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