Topotecan(Tpt)

Product Name: Topotecan(Tpt)
CAS No.: 139339-45-0
Chemical Name: Topotecan(Tpt)
Synonyms: Ro 24-7429;Ro24-7429, 10 mM in DMSO;Tat,anti-inflammatory,antifibrotic,inhibit,Ro247429,Ro24-7429,RUNX1,Inhibitor,Apoptosis,Human immunodeficiency virus,HIV-1,anti-HIV,Ro24 7429,HIV
CBNumber: CB41030572
Molecular Formula: C14H13ClN4
Formula Weight: 272.73
MOL File: 139339-45-0.mol

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Topotecan(Tpt) Property

storage temp.: Store at -20°C
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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Topotecan(Tpt) Chemical Properties,Usage,Production

Uses

Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].

Definition

ChEBI: 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine is a benzodiazepine.

in vivo

Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs^[2].

Animal Model:	C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin^[2]
Dosage:	17.5 mg/kg, 35 mg/kg, and 70 mg/kg
Administration:	i.p.; daily; for 14 or 21 days
Result:	Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model.

IC 50

HIV-1

References

[1] A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. DOI:10.1006/cimm.1996.0088
[2] Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208. DOI:10.1016/j.ajpath.2021.04.006

Topotecan(Tpt) Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 24-7429

Tat,anti-inflammatory,antifibrotic,inhibit,Ro247429,Ro24-7429,RUNX1,Inhibitor,Apoptosis,Human immunodeficiency virus,HIV-1,anti-HIV,Ro24 7429,HIV

Ro24-7429, 10 mM in DMSO

139339-45-0

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