5-CYANO-2-FLUOROBENZALDEHYDE

Product Name: 5-CYANO-2-FLUOROBENZALDEHYDE
CAS No.: 146137-79-3
Chemical Name: 5-CYANO-2-FLUOROBENZALDEHYDE
Synonyms: Olaparib Impurity 160;3-Cyano-6-fluorobenzaldehyde;5-CYANO-2-FLUOROBENZALDEHYDE;4-FLUORO-3-FORMYL-BENZONITRILE;Benzonitrile, 4-fluoro-3-forMyl-;Benzonitrile, 4-fluoro-3-formyl- (9CI);5-CYANO-2-FLUOROBENZALDEHYDE ISO 9001：2015 REACH
CBNumber: CB1474714
Molecular Formula: C8H4FNO
Formula Weight: 149.12
MOL File: 146137-79-3.mol

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5-CYANO-2-FLUOROBENZALDEHYDE Property

Boiling point:: 216.5±20.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
color: Light yellow to yellow
CAS DataBase Reference: 146137-79-3(CAS DataBase Reference)

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Safety

HazardClass: IRRITANT
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C988153
Product name: 5-Cyano-2-fluorobenzaldehyde
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 057614
Product name: 4-Fluoro-3-formylbenzonitrile
Purity: 98%
Packaging: 500mg
Price: $21
Updated: 2021/12/16

AK Scientific

Product number: N520
Product name: 5-Cyano-2-fluorobenzaldehyde
Packaging: 1g
Price: $27
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC51241
Product name: 5-Cyano-2-fluorobenzaldehyde
Packaging: 500mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4637-3-90
Product name: 4-Fluoro-3-Formylbenzonitrile
Purity: 97%
Packaging: 250mg
Price: $81
Updated: 2021/12/16

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5-CYANO-2-FLUOROBENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

1194-02-1

146137-79-3

The general procedure for the synthesis of 4-fluoro-3-formylbenzonitrile from p-fluorobenzonitrile is as follows: Example 112 Synthesis of 2-fluoro-5-cyanobenzaldehyde To a stirred solution of cooled diisopropylamine (15.4 mL, 0.11 mol) in anhydrous tetrahydrofuran (200 mL) under argon protection, n-butyllithium (40 mL, 2.5 M hexane solution, 0.11 mol) was slowly added through a dropping funnel over a period of 30 minutes, keeping the reaction temperature at 0°C. The mixture was continued to be stirred at this temperature for 30 minutes. Subsequently, the reaction system was cooled to -78 °C. A solution of anhydrous tetrahydrofuran (50 mL) of 4-fluorobenzonitrile (12.1 g, 0.1 mol) was added dropwise over 15 minutes. The reaction mixture was stirred at -78 °C for 1 h via syringe. Then, dimethylformamide (8 mL) was added dropwise and stirring was continued at -78 °C for 20 min. The reaction was quenched by rapid addition of acetic acid (20 mL) followed by water (500 mL). The product was extracted with ether (2 x 500 mL). The combined organic layers were washed sequentially with 1N HCl, water and saturated sodium chloride solution and then dried with anhydrous magnesium sulfate. After evaporation of the solvent, 2-fluoro-5-cyanobenzaldehyde (11.8 g, 79% yield) was obtained as a light yellow solid. 1H NMR (CDCl3): δ 10.32 (s, 1H), 8.18 (dd, 1H, J = 6.5, 2.5 Hz), 7.88 (m, 1H), 7.33 (t, 1H, J = 9.5 Hz).

References

[1] Patent: US6221914, 2001, B1
[2] Patent: US2002/103229, 2002, A1
[3] Patent: US2004/127536, 2004, A1
[4] Patent: US2005/9876, 2005, A1

5-CYANO-2-FLUOROBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CYANO-2-FLUOROBENZALDEHYDE Suppliers

China 153 Europe 2 Germany 1 India 2 Italy 1 United Kingdom 6 United States 21 Global 186

J & K SCIENTIFIC LTD.

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Jia Xing Isenchem Co.,Ltd

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Shanghai Longsheng chemical Co.,Ltd.

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View Lastest Price from 5-CYANO-2-FLUOROBENZALDEHYDE manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 5-CYANO-2-FLUOROBENZALDEHYDE 146137-79-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-10

Shaanxi Dideu New Materials Co. Ltd

Product: 5-CYANO-2-FLUOROBENZALDEHYDE 146137-79-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-29

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Fluoro-3-formylbenzonitrile 146137-79-3
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-13

146137-79-3, 5-CYANO-2-FLUOROBENZALDEHYDERelated Search:

4-BROMO-3-NITROANILINE 1-Iodoheptane DL-Mandelic acid 5-Bromo-3-nitropyridine-2-carbonitrile 4-Bromophenoxybenzene Iron(III) trifluoromethanesulfonate 2-CYANO-6-FLUOROBENZALDEHYDE 3-Cyano-4-fluorobenzaldehyde 97%,3-Cyano-4-fluorobenzaldehyde97%,3-CYANO-4-FLUOROBENZALDEHYDE 2-CYANO-4-FLUOROBENZALDEHYDE 4-CYANO-2-FLUOROBENZALDEHYDE Topotecan(Tpt) 5-CYANO-2-FLUOROBENZALDEHYDE 2-Cyano-5-fluorobenzaldehyde 3-Cyano-5-fluorobenzaldehyde 4-CYANO-3-FLUOROBENZALDEHYDE 2,4-DIFLUORO-3-FORMYLBENZONITRILE 5-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER 5-CYANO-2-FLUOROBENZOIC ACID ETHYL ESTER

5-CYANO-2-FLUOROBENZALDEHYDE

4-FLUORO-3-FORMYL-BENZONITRILE

Benzonitrile, 4-fluoro-3-formyl- (9CI)

3-Cyano-6-fluorobenzaldehyde

Benzonitrile, 4-fluoro-3-forMyl-

5-CYANO-2-FLUOROBENZALDEHYDE ISO 9001：2015 REACH

Olaparib Impurity 160

146137-79-3

C8H4FNO

HALIDE

ALDEHYDE

Benzaldehyde

Miscellaneous

Benzenes