ChemicalBook > CAS DataBase List > 5-CYANO-2-FLUOROBENZALDEHYDE

5-CYANO-2-FLUOROBENZALDEHYDE

Product Name
5-CYANO-2-FLUOROBENZALDEHYDE
CAS No.
146137-79-3
Chemical Name
5-CYANO-2-FLUOROBENZALDEHYDE
Synonyms
Olaparib Impurity 160;3-Cyano-6-fluorobenzaldehyde;5-CYANO-2-FLUOROBENZALDEHYDE;4-FLUORO-3-FORMYL-BENZONITRILE;Benzonitrile, 4-fluoro-3-forMyl-;Benzonitrile, 4-fluoro-3-formyl- (9CI);5-CYANO-2-FLUOROBENZALDEHYDE ISO 9001：2015 REACH
CBNumber
CB1474714
Molecular Formula
C8H4FNO
Formula Weight
149.12
MOL File
146137-79-3.mol
More
Less

5-CYANO-2-FLUOROBENZALDEHYDE Property

Boiling point:
216.5±20.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
Light yellow to yellow
CAS DataBase Reference
146137-79-3(CAS DataBase Reference)
More
Less

Safety

HazardClass 
IRRITANT
HS Code 
2926907090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

TRC
Product number
C988153
Product name
5-Cyano-2-fluorobenzaldehyde
Packaging
50mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
N520
Product name
5-Cyano-2-fluorobenzaldehyde
Packaging
1g
Price
$27
Updated
2021/12/16
Matrix Scientific
Product number
057614
Product name
4-Fluoro-3-formylbenzonitrile
Purity
98%
Packaging
500mg
Price
$21
Updated
2021/12/16
SynQuest Laboratories
Product number
4637-3-90
Product name
4-Fluoro-3-Formylbenzonitrile
Purity
97%
Packaging
250mg
Price
$81
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC51241
Product name
5-Cyano-2-fluorobenzaldehyde
Packaging
1g
Price
$100
Updated
2021/12/16
More
Less

5-CYANO-2-FLUOROBENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

1194-02-1

146137-79-3

The general procedure for the synthesis of 4-fluoro-3-formylbenzonitrile from p-fluorobenzonitrile is as follows: Example 112 Synthesis of 2-fluoro-5-cyanobenzaldehyde To a stirred solution of cooled diisopropylamine (15.4 mL, 0.11 mol) in anhydrous tetrahydrofuran (200 mL) under argon protection, n-butyllithium (40 mL, 2.5 M hexane solution, 0.11 mol) was slowly added through a dropping funnel over a period of 30 minutes, keeping the reaction temperature at 0°C. The mixture was continued to be stirred at this temperature for 30 minutes. Subsequently, the reaction system was cooled to -78 °C. A solution of anhydrous tetrahydrofuran (50 mL) of 4-fluorobenzonitrile (12.1 g, 0.1 mol) was added dropwise over 15 minutes. The reaction mixture was stirred at -78 °C for 1 h via syringe. Then, dimethylformamide (8 mL) was added dropwise and stirring was continued at -78 °C for 20 min. The reaction was quenched by rapid addition of acetic acid (20 mL) followed by water (500 mL). The product was extracted with ether (2 x 500 mL). The combined organic layers were washed sequentially with 1N HCl, water and saturated sodium chloride solution and then dried with anhydrous magnesium sulfate. After evaporation of the solvent, 2-fluoro-5-cyanobenzaldehyde (11.8 g, 79% yield) was obtained as a light yellow solid. 1H NMR (CDCl3): δ 10.32 (s, 1H), 8.18 (dd, 1H, J = 6.5, 2.5 Hz), 7.88 (m, 1H), 7.33 (t, 1H, J = 9.5 Hz).

References

[1] Patent: US6221914, 2001, B1
[2] Patent: US2002/103229, 2002, A1
[3] Patent: US2004/127536, 2004, A1
[4] Patent: US2005/9876, 2005, A1

5-CYANO-2-FLUOROBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-CYANO-2-FLUOROBENZALDEHYDE Suppliers

China 153 Europe 2 Germany 1 India 2 Italy 1 United Kingdom 6 United States 21 Global 186
CHEMSTEP
Tel
--
Fax
--
Email
info@chemstep.com
Country
Europe
ProdList
6143
Advantage
51
Nantong Chem-Tech.(Group) Co., Ltd
Tel
--
Fax
--
Email
ni.trade@pub.nt.jsinfo.net
Country
Europe
ProdList
1811
Advantage
56
More
Less

View Lastest Price from 5-CYANO-2-FLUOROBENZALDEHYDE manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
5-CYANO-2-FLUOROBENZALDEHYDE 146137-79-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-10-10
Shaanxi Dideu New Materials Co. Ltd
Product
5-CYANO-2-FLUOROBENZALDEHYDE 146137-79-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-29
Shaanxi Dideu Medichem Co. Ltd
Product
4-Fluoro-3-formylbenzonitrile 146137-79-3
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-13

146137-79-3, 5-CYANO-2-FLUOROBENZALDEHYDERelated Search:

4-BROMO-3-NITROANILINE 1-Iodoheptane DL-Mandelic acid 5-Bromo-3-nitropyridine-2-carbonitrile 4-Bromophenoxybenzene Iron(III) trifluoromethanesulfonate 2-CYANO-6-FLUOROBENZALDEHYDE 3-Cyano-4-fluorobenzaldehyde 97%,3-Cyano-4-fluorobenzaldehyde97%,3-CYANO-4-FLUOROBENZALDEHYDE 2-CYANO-4-FLUOROBENZALDEHYDE 4-CYANO-2-FLUOROBENZALDEHYDE Topotecan(Tpt) 5-CYANO-2-FLUOROBENZALDEHYDE 2-Cyano-5-fluorobenzaldehyde 3-Cyano-5-fluorobenzaldehyde 4-CYANO-3-FLUOROBENZALDEHYDE 2,4-DIFLUORO-3-FORMYLBENZONITRILE 5-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER 5-CYANO-2-FLUOROBENZOIC ACID ETHYL ESTER

  • 5-CYANO-2-FLUOROBENZALDEHYDE
  • 4-FLUORO-3-FORMYL-BENZONITRILE
  • Benzonitrile, 4-fluoro-3-formyl- (9CI)
  • 3-Cyano-6-fluorobenzaldehyde
  • Benzonitrile, 4-fluoro-3-forMyl-
  • 5-CYANO-2-FLUOROBENZALDEHYDE ISO 9001：2015 REACH
  • Olaparib Impurity 160
  • 146137-79-3
  • C8H4FNO
  • HALIDE
  • ALDEHYDE
  • Benzaldehyde
  • Miscellaneous
  • Benzenes