2-Fluoro-5-formylbenzonitrile
- Product Name
- 2-Fluoro-5-formylbenzonitrile
- CAS No.
- 218301-22-5
- Chemical Name
- 2-Fluoro-5-formylbenzonitrile
- Synonyms
- 3-CYANO-4-FLUOROBENZALDEHYDE;2-Fluor-5-formylbenzonitrile;FFBN;uoro-5-formyL;CYANOFLUOROBENZALDEHYDE-3-4;4-Fluoro-3-cyanobenzaldehyde;2-FLUORO-5-FORMYLBENZONITRILE;3-cyano-4-flluorobenzaldehyde;2-Fluoro-S-formylbenzonitrile;3-Cyano-4-fluorobenzaldehyde97%
- CBNumber
- CB5293829
- Molecular Formula
- C8H4FNO
- Formula Weight
- 149.12
- MOL File
- 218301-22-5.mol
2-Fluoro-5-formylbenzonitrile Property
- Melting point:
- 80-84 °C (lit.)
- Boiling point:
- 215.6±20.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Solid
- color
- White
- InChI
- InChI=1S/C8H4FNO/c9-8-2-1-6(5-11)3-7(8)4-10/h1-3,5H
- InChIKey
- MOFRJTLODZILCR-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC(C=O)=CC=C1F
- CAS DataBase Reference
- 218301-22-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 494089
- Product name
- 2-Fluoro-5-formylbenzonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $351
- Updated
- 2023/06/20
- Product number
- C2692
- Product name
- 3-Cyano-4-fluorobenzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- C2692
- Product name
- 3-Cyano-4-fluorobenzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $94
- Updated
- 2024/03/01
- Product number
- C987515
- Product name
- 3-Cyano-4-fluorobenzaldehyde
- Packaging
- 10g
- Price
- $950
- Updated
- 2021/12/16
- Product number
- 4637-3-14
- Product name
- 3-Cyano-4-fluorobenzaldehyde
- Purity
- 98%
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
2-Fluoro-5-formylbenzonitrile Chemical Properties,Usage,Production
Description
2-Fluoro-5-formylbenzonitrile is a pharmaceutical intermediate compound used in the preparation of Olaparib, a PARP inhibitor for the treatment of a variety of cancers including advanced ovarian, fallopian tube, or primary peritoneal cancers with a certain hereditary (germline) or acquired (somatic) abnormality of the BRCA gene.
Chemical Properties
White Solid
Uses
2-Fluoro-5-formylbenzonitrile may be used in the synthesis of 3-cyano-4-fluorobenzyl bromide. It could be used to synthesis 2-fluoro-5-(4-ethoxybenzyl)benzonitrile. 2-Fluoro-5-formylbenzonitrile (10g, 1eq) was dissolved in 100mL 1,4-dioxane, p-toluenesulfonyl hydrazide (13.7g, 1eq) was added, stirred at room temperature for 3 hours, and then added Potassium carbonate (13.9 g, 1.5 eq), 4-ethoxyphenylboronic acid (12.2 g, 1 eq), warmed to 100 C. and stirred for 12 hours. After TLC monitoring the reaction of the raw materials, filter, spin dry the filtrate, add petroleum ether and stir for half an hour, filter, and spin dry the filtrate to obtain 15 g of 2-fluoro-5-(4-ethoxybenzyl)benzonitrile (the yield is 88%).
Uses
2-Fluoro-5-ForMyl-benzonitrile is used in the preparation of heterocyclic compounds as PARP inhibitors for medical use.
General Description
2-Fluoro-5-formylbenzonitrile is a benzonitrile derivative.
2-Fluoro-5-formylbenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-5-formylbenzonitrile manufacturers
- Product
- 2-Fluoro-5-formylbenzonitrile 218301-22-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-27
- Product
- 2-fluoro-5-formylbenzonitrile 218301-22-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 0.99
- Supply Ability
- 1 tons
- Release date
- 2024-11-15
- Product
- 2-FLUORO-5-FORMYLBENZONITRILE 218301-22-5
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08