ChemicalBook > CAS DataBase List > 2-Fluoro-5-formylbenzonitrile

2-Fluoro-5-formylbenzonitrile

Product Name
2-Fluoro-5-formylbenzonitrile
CAS No.
218301-22-5
Chemical Name
2-Fluoro-5-formylbenzonitrile
Synonyms
3-CYANO-4-FLUOROBENZALDEHYDE;2-Fluor-5-formylbenzonitrile;FFBN;uoro-5-formyL;CYANOFLUOROBENZALDEHYDE-3-4;4-Fluoro-3-cyanobenzaldehyde;2-FLUORO-5-FORMYLBENZONITRILE;3-cyano-4-flluorobenzaldehyde;2-Fluoro-S-formylbenzonitrile;3-Cyano-4-fluorobenzaldehyde97%
CBNumber
CB5293829
Molecular Formula
C8H4FNO
Formula Weight
149.12
MOL File
218301-22-5.mol
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2-Fluoro-5-formylbenzonitrile Property

Melting point:
80-84 °C (lit.)
Boiling point:
215.6±20.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol
form 
Solid
color 
White
InChI
InChI=1S/C8H4FNO/c9-8-2-1-6(5-11)3-7(8)4-10/h1-3,5H
InChIKey
MOFRJTLODZILCR-UHFFFAOYSA-N
SMILES
C(#N)C1=CC(C=O)=CC=C1F
CAS DataBase Reference
218301-22-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
494089
Product name
2-Fluoro-5-formylbenzonitrile
Purity
97%
Packaging
5g
Price
$351
Updated
2023/06/20
TCI Chemical
Product number
C2692
Product name
3-Cyano-4-fluorobenzaldehyde
Purity
>98.0%(GC)
Packaging
1g
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
C2692
Product name
3-Cyano-4-fluorobenzaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$94
Updated
2024/03/01
TRC
Product number
C987515
Product name
3-Cyano-4-fluorobenzaldehyde
Packaging
10g
Price
$950
Updated
2021/12/16
SynQuest Laboratories
Product number
4637-3-14
Product name
3-Cyano-4-fluorobenzaldehyde
Purity
98%
Packaging
25g
Price
$75
Updated
2021/12/16
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2-Fluoro-5-formylbenzonitrile Chemical Properties,Usage,Production

Description

2-Fluoro-5-formylbenzonitrile is a pharmaceutical intermediate compound used in the preparation of Olaparib, a PARP inhibitor for the treatment of a variety of cancers including advanced ovarian, fallopian tube, or primary peritoneal cancers with a certain hereditary (germline) or acquired (somatic) abnormality of the BRCA gene.

Chemical Properties

White Solid

Uses

2-Fluoro-5-formylbenzonitrile may be used in the synthesis of 3-cyano-4-fluorobenzyl bromide. It could be used to synthesis 2-fluoro-5-(4-ethoxybenzyl)benzonitrile. 2-Fluoro-5-formylbenzonitrile (10g, 1eq) was dissolved in 100mL 1,4-dioxane, p-toluenesulfonyl hydrazide (13.7g, 1eq) was added, stirred at room temperature for 3 hours, and then added Potassium carbonate (13.9 g, 1.5 eq), 4-ethoxyphenylboronic acid (12.2 g, 1 eq), warmed to 100 C. and stirred for 12 hours. After TLC monitoring the reaction of the raw materials, filter, spin dry the filtrate, add petroleum ether and stir for half an hour, filter, and spin dry the filtrate to obtain 15 g of 2-fluoro-5-(4-ethoxybenzyl)benzonitrile (the yield is 88%).

Uses

2-Fluoro-5-ForMyl-benzonitrile is used in the preparation of heterocyclic compounds as PARP inhibitors for medical use.

General Description

2-Fluoro-5-formylbenzonitrile is a benzonitrile derivative.

2-Fluoro-5-formylbenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-5-formylbenzonitrile Suppliers

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View Lastest Price from 2-Fluoro-5-formylbenzonitrile manufacturers

Nanjing Fred Technology Co., Ltd
Product
2-Fluoro-5-formylbenzonitrile 218301-22-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-27
Suzhou Nordica Biopharma CO.,LTD
Product
2-fluoro-5-formylbenzonitrile 218301-22-5
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
0.99
Supply Ability
1 tons
Release date
2024-11-15
Henan Fengda Chemical Co., Ltd
Product
2-FLUORO-5-FORMYLBENZONITRILE 218301-22-5
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

218301-22-5, 2-Fluoro-5-formylbenzonitrileRelated Search:

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