3-FLUORO-5-FORMYLBENZONITRILE
- Product Name
- 3-FLUORO-5-FORMYLBENZONITRILE
- CAS No.
- 1003708-42-6
- Chemical Name
- 3-FLUORO-5-FORMYLBENZONITRILE
- Synonyms
- 3-FLUORO-5-FORMYLBENZONITRILE;Benzonitrile, 3-fluoro-5-formyl-;4-Chloro-4-(trifluoromethyl)acetophenone
- CBNumber
- CB7534339
- Molecular Formula
- C8H4FNO
- Formula Weight
- 149.12
- MOL File
- Mol file
3-FLUORO-5-FORMYLBENZONITRILE Property
- Boiling point:
- 205℃
- Density
- 1.25
- Flash point:
- 77℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- Off-white
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- F532040
- Product name
- 3-Fluoro-5-formylbenzonitrile
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- X8502
- Product name
- 3-Fluoro-5-formylbenzonitrile
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 067013
- Product name
- 3-Fluoro-5-formylbenzonitrile
- Purity
- >95%
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 067013
- Product name
- 3-Fluoro-5-formylbenzonitrile
- Purity
- >95%
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- PC200339
- Product name
- 3-Fluoro-5-formylbenzonitrile
- Purity
- 98%
- Packaging
- 5g
- Price
- $254
- Updated
- 2021/12/16
3-FLUORO-5-FORMYLBENZONITRILE Chemical Properties,Usage,Production
Uses
3-Fluoro-5-formylbenzonitrile is benzaldehyde based building block used as a reactant in catalyst-free synthesis of N-β-hydroxyethyl pyrroles and indoles via a domino [3+2] cycloaddition and ring-opening aromatization process.
Application
3-FLUORO-5-FORMYLBENZONITRILE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
3 -fluoro-5 -formylbenzonitrile : A solution of 3 -bromo-5 -fluorobenzonitrile(5.00 g, 25.0 mmol) in dry THF (25 mL) was cooled to 0 °C and 2M iPrMgCl (15.0 mL, 30.0 mmol) in THF was added dropwise over 5 minutes. The mixture was stirred at 0 °C for 15 minutes then at ambient temperature for 1 hour. The mixture was cooled to 0 °C and dry DMF (5.81 mL, 75.0 mmol) was added. The mixture was stirred for 17 hours during which time the temperature reached ambient temperature after 2 hours. The mixture was added to ice water (150 mL) and Et20 (100 mL). The biphasic mixture was stirred and treated with 6M HC1 to aqueous pH=3. The organic layer was removed and the aqueous layer extracted with Et20 (2X). The combined Et20 fractions were washed with saturated NaCl and dried over MgS04/activated carbon. The dried solution was filtered through a S1O2 plug eluting with Et20. The filtrate was concentrated to give the title compound as a yellow solid that was dried in vacuum (3.68 g, 99percent). 1H NMR (CDC13) δ 10.0 (s, 1H), 8.00 (s, 1H), 7.81-7.86 (m, 1H), 7.62-7.67 (m, 1H).
3-FLUORO-5-FORMYLBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-5-FORMYLBENZONITRILE manufacturers
- Product
- 3-FLUORO-5-FORMYLBENZONITRILE 1003708-42-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-02