Benzenamine, 2,6-difluoro-4-methoxy- (9CI)
- Product Name
- Benzenamine, 2,6-difluoro-4-methoxy- (9CI)
- CAS No.
- 151414-47-0
- Chemical Name
- Benzenamine, 2,6-difluoro-4-methoxy- (9CI)
- Synonyms
- 4-Amino-3,5-difluoroanisole;2,6-Difluoro-4-methoxybenzenamine;Benzenamine, 2,6-difluoro-4-methoxy-;Benzenamine, 2,6-difluoro-4-methoxy- (9CI);4-Amino-3,5-difluoroanisole, 2,6-Difluoro-p-anisidine;4-AMino-3,5-difluoroanisole[2,6-Difluoro-4-Methoxyaniline]
- CBNumber
- CB41045510
- Molecular Formula
- C7H7F2NO
- Formula Weight
- 159.13
- MOL File
- 151414-47-0.mol
Benzenamine, 2,6-difluoro-4-methoxy- (9CI) Property
- Melting point:
- 38-40℃
- Boiling point:
- 172.4±35.0 °C(Predicted)
- Density
- 1.281±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.41±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
- Water Solubility
- Insoluble in water.
Safety
- RIDADR
- 2810
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2922290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D473518
- Product name
- 2,6-Difluoro-4-methoxyaniline
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC5543
- Product name
- 2,6-Difluoro-4-methoxyaniline
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 072784
- Product name
- 2,6-Difluoro-4-methoxyaniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- W3307
- Product name
- 2,6-Difluoro-4-methoxyaniline
- Packaging
- 1g
- Price
- $111
- Updated
- 2021/12/16
- Product number
- PC5543
- Product name
- 2,6-Difluoro-4-methoxyaniline
- Packaging
- 5g
- Price
- $125
- Updated
- 2021/12/16
Benzenamine, 2,6-difluoro-4-methoxy- (9CI) Chemical Properties,Usage,Production
Uses
2,6-Difluoro-4-methoxyaniline is used as primary and secondary intermediate.
Synthesis
67-56-1
315-14-0
151414-47-0
Example 58A; Synthesis of 2,6-difluoro-4-methoxyaniline; 10 g (56 mmol) of 1,3,5-trifluoro-2-nitrobenzene was dissolved in 250 mL of methanol, and a methanolic solution of 3.36 g (62 mmol) of sodium methanolate (250 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure by rotary evaporator and the residue was hydrolyzed with dilute aqueous hydrochloric acid solution followed by extraction with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and filtered to give the crude product. The crude product was dissolved in 110 mL of methanol, 275 mg of 10% palladium carbon catalyst was added and the hydrogenation reaction was carried out at room temperature overnight. After the reaction, the catalyst was removed by diatomaceous earth filtration, and the filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, v/v/v/9:1), resulting in 1.24 g of the target product 2,6-difluoro-4-methoxyaniline in 14% yield. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ=3.66 (s, 3H, OCH3), 4.60 (br.s, 2H, NH2), 6.55-6.70 (m, 2H, ArH).
References
[1] Patent: WO2003/76405, 2003, A1. Location in patent: Page/Page column 85
Benzenamine, 2,6-difluoro-4-methoxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzenamine, 2,6-difluoro-4-methoxy- (9CI) manufacturers
- Product
- 2,6-Difluoro-4-methoxyaniline 151414-47-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.8%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08