Benzenamine, 2,6-difluoro-4-methoxy- (9CI)

Benzenamine, 2,6-difluoro-4-methoxy- (9CI) Property

Melting point:

38-40℃

Boiling point:

172.4±35.0 °C(Predicted)

Density 

1.281±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2.41±0.10(Predicted)

Appearance

Off-white to light brown Solid

Water Solubility 

Insoluble in water.

Safety

RIDADR 

2810

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

2922290090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

Benzenamine, 2,6-difluoro-4-methoxy- (9CI) Chemical Properties,Usage,Production

Uses

2,6-Difluoro-4-methoxyaniline is used as primary and secondary intermediate.

Synthesis

Example 58A; Synthesis of 2,6-difluoro-4-methoxyaniline; 10 g (56 mmol) of 1,3,5-trifluoro-2-nitrobenzene was dissolved in 250 mL of methanol, and a methanolic solution of 3.36 g (62 mmol) of sodium methanolate (250 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure by rotary evaporator and the residue was hydrolyzed with dilute aqueous hydrochloric acid solution followed by extraction with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and filtered to give the crude product. The crude product was dissolved in 110 mL of methanol, 275 mg of 10% palladium carbon catalyst was added and the hydrogenation reaction was carried out at room temperature overnight. After the reaction, the catalyst was removed by diatomaceous earth filtration, and the filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, v/v/v/9:1), resulting in 1.24 g of the target product 2,6-difluoro-4-methoxyaniline in 14% yield. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ=3.66 (s, 3H, OCH3), 4.60 (br.s, 2H, NH2), 6.55-6.70 (m, 2H, ArH).

References

[1] Patent: WO2003/76405, 2003, A1. Location in patent: Page/Page column 85