Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI)
- Product Name
- Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI)
- CAS No.
- 87674-21-3
- Chemical Name
- Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI)
- Synonyms
- 4-Acetyl-3-fluoropyridine;3-Fluoro-4-acetylpyridine;1-(3-Fluoro-4-pyridinyl)ethanone;1-(3-fluoropyridin-4-yl)ethan-1-one;Ethanone, 1-(3-fluoro-4-pyridinyl)-;Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI);Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB41052860
- Molecular Formula
- C7H6FNO
- Formula Weight
- 139.13
- MOL File
- 87674-21-3.mol
Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI) Property
- Boiling point:
- 199℃
- Density
- 1.175
- Flash point:
- 74℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.10±0.18(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C7H6FNO/c1-5(10)6-2-3-9-4-7(6)8/h2-4H,1H3
- InChIKey
- PPULDLJGJZUOBS-UHFFFAOYSA-N
- SMILES
- C(=O)(C1C=CN=CC=1F)C
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F596315
- Product name
- 1-(3-Fluoropyridin-4-yl)ethanone
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC201340
- Product name
- 1-(3-Fluoropyridin-4-yl)ethanone
- Purity
- 98%
- Packaging
- 250mg
- Price
- $111
- Updated
- 2021/12/16
- Product number
- W9003
- Product name
- 1-(3-Fluoropyridin-4-yl)ethanone
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- HCH0353949
- Product name
- 1-(3-FLUOROPYRIDIN-4-YL)ETHANONE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $257.25
- Updated
- 2021/12/16
- Product number
- PC201340
- Product name
- 1-(3-Fluoropyridin-4-yl)ethanone
- Purity
- 98%
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI) Chemical Properties,Usage,Production
Synthesis
1187669-49-3
75-16-1
87674-21-3
Step 2: Synthesis of 1-(3-fluoropyridin-4-yl)ethanone To a stirred solution of 3-fluoro-N-methoxy-N-methylpyridine-4-carboxamide (1.2 g, 6.5 mmol) in tetrahydrofuran (THF) (15 mL) was slowly added methylmagnesium bromide (2M solution in THF, 16 mL, 32 mmol) at 0 °C. After addition, the reaction mixture was brought to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution and subsequently extracted with ethyl acetate (EtOAc). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford 0.650 g (92% yield) of the target product 1-(3-fluoropyridin-4-yl)ethanone as a colorless oil. Mass spectrum (MS): 140.1 [M+H]+.
References
[1] Patent: US2017/291894, 2017, A1. Location in patent: Paragraph 0486-0488
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 2, p. 787 - 797
[3] Patent: WO2009/114552, 2009, A1. Location in patent: Page/Page column 167
Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI) manufacturers
- Product
- Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI) 87674-21-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26