ChemicalBook > CAS DataBase List > NEUROPEPTIDE S (HUMAN)

NEUROPEPTIDE S (HUMAN)

Product Name: NEUROPEPTIDE S (HUMAN)
CAS No.: 412938-67-1
Chemical Name: NEUROPEPTIDE S (HUMAN)
Synonyms: NPS (HUMAN);SFRNGVGTGMKKTSFQRAKS;NEUROPEPTIDE S (HUMAN);Neuropeptide S, NPS, human;Neuropeptide S, NPS, human - 1 mg;Neuropeptide S (huMan) NPS (huMan);Neuropeptide S (human) trifluoroacetate;SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER;H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH;REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH
CBNumber: CB4106928
Molecular Formula: C93H155N31O28S
Formula Weight: 2187.48
MOL File: 412938-67-1.mol

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NEUROPEPTIDE S (HUMAN) Property

Density: 1.49±0.1 g/cm3(Predicted)
form: Solid
color: White to off-white
Sequence: Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 302078
Product name: Neuropeptide S, Human
Packaging: 100ug
Price: $372
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0003707
Product name: NEUROPEPTIDE S, HUMAN
Purity: 95.00%
Packaging: 0.5MG
Price: $676.83
Updated: 2021/12/16

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NEUROPEPTIDE S (HUMAN) Chemical Properties,Usage,Production

Uses

Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research[1].

Biological Activity

Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50=9.4 nM). It (TFA) increases motor activity and wakefulness in mice, and has potential for Alzheimer's disease (AD) research.

in vitro

Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC ₅₀ of 6.7 ± 2.4 nM, the binding of [ ^{125I ] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K _d = 0.33 ± 0.12 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [ ^125I I] Y10-NPS, [ ^125I I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC ₅₀ = 0.42 ± 0.12 nM).}

in vivo

Neuropeptide S human (0.1 nM-1 nM; icv) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice .

Animal Model:	Male C57Bl/6 mice
Dosage:	0.1 nM, 1 nM
Administration:	Intracerebroventricular (icv) injection
Result:	Increased locomotor activity and promoted wakefulness.

target

EC50: 9.4 nM (neuropeptide S receptor)

References

[1] Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97. DOI:10.1016/j.neuron.2004.08.005

NEUROPEPTIDE S (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

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412938-67-1, NEUROPEPTIDE S (HUMAN)Related Search:

ALPHA-MSH H-SER-PHE-ARG-ASN-GLY-VAL-GLY-SER-GLY-VAL-LYS-LYS-THR-SER-PHE-ARG-ARG-ALA-LYS-GLN-OH PubChem ID: 54581309 DEMETON S NEUROPEPTIDE S (HUMAN)

SFRNGVGTGMKKTSFQRAKS

SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER

NPS (HUMAN)

NEUROPEPTIDE S (HUMAN)

H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH

REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH

Neuropeptide S, NPS, human

Neuropeptide S (huMan) NPS (huMan)

L-Serine, L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-threonylglycyl-L-methionyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl-

Neuropeptide S, NPS, human - 1 mg

Neuropeptide S (human) trifluoroacetate

412938-67-1

peptide

Various peptides