NEUROPEPTIDE S (HUMAN)
- Product Name
- NEUROPEPTIDE S (HUMAN)
- CAS No.
- 412938-67-1
- Chemical Name
- NEUROPEPTIDE S (HUMAN)
- Synonyms
- NPS (HUMAN);SFRNGVGTGMKKTSFQRAKS;NEUROPEPTIDE S (HUMAN);Neuropeptide S, NPS, human;Neuropeptide S (huMan) NPS (huMan);SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER;H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH;REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH;L-Serine, L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-threonylglycyl-L-methionyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl-
- CBNumber
- CB4106928
- Molecular Formula
- C93H155N31O28S
- Formula Weight
- 2187.48
- MOL File
- 412938-67-1.mol
NEUROPEPTIDE S (HUMAN) Property
- Density
- 1.49±0.1 g/cm3(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- J66262
- Product name
- Neuropeptide S, human
- Packaging
- 0.2mg
- Price
- $111
- Updated
- 2021/12/16
- Product number
- J66262
- Product name
- Neuropeptide S, human
- Packaging
- 0.5mg
- Price
- $201
- Updated
- 2021/12/16
- Product number
- J66262
- Product name
- Neuropeptide S, human
- Packaging
- 1mg
- Price
- $301
- Updated
- 2021/12/16
- Product number
- 302078
- Product name
- Neuropeptide S, Human
- Packaging
- 100ug
- Price
- $372
- Updated
- 2021/12/16
- Product number
- PEP0003707
- Product name
- NEUROPEPTIDE S, HUMAN
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $676.83
- Updated
- 2021/12/16
NEUROPEPTIDE S (HUMAN) Chemical Properties,Usage,Production
Biological Activity
Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50=9.4 nM). It (TFA) increases motor activity and wakefulness in mice, and has potential for Alzheimer's disease (AD) research.
in vitro
Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC 50 of 6.7 ± 2.4 nM, the binding of [ 125I sup> ] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K d = 0.33 ± 0.12 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [ 125I I] Y10-NPS, [ 125I I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC 50 = 0.42 ± 0.12 nM).
in vivo
Neuropeptide S human (0.1 nM-1 nM; icv) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice .
Animal Model: | Male C57Bl/6 mice |
Dosage: | 0.1 nM, 1 nM |
Administration: | Intracerebroventricular (icv) injection |
Result: | Increased locomotor activity and promoted wakefulness. |
target
EC50: 9.4 nM (neuropeptide S receptor)
NEUROPEPTIDE S (HUMAN) Preparation Products And Raw materials
Raw materials
Preparation Products
NEUROPEPTIDE S (HUMAN) Suppliers
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