ChemicalBook > CAS DataBase List > Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro-
Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro-
- Product Name
- Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro-
- CAS No.
- 867301-81-3
- Chemical Name
- Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro-
- Synonyms
- WAY-659694;WAY659694,WAY 659694;Anti-inflammatory agent 34;N-(4-Methyl-2-oxo-2H-chromen-7-yl)-4-nitrobenzamide;Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro-
- CBNumber
- CB410724112
- Molecular Formula
- C17H12N2O5
- Formula Weight
- 324.29
- MOL File
- 867301-81-3.mol
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Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro- Property
- Melting point:
- >320 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 470.4±45.0 °C(Predicted)
- Density
- 1.436±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF : 1.85 mg/mL (5.70 mM; ultrasonic and warming and heat to 60°C)
- pka
- 11.05±0.20(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro- Chemical Properties,Usage,Production
Uses
Anti-inflammatory agent 34 (Compound IVf) is an orally active anti-inflammatory and analgesic agent[1].
in vivo
Anti-inflammatory agent 34 (Compound IVf) (200mg/kg; p.o.; single dose) shows inhibitory activity on carrageenan induced rat paw edema, and shows analgesic activity in mice[1].
| Animal Model: | Male albino rats, carrageenan-induced rat paw edema assay model[1] |
| Dosage: | 200 mg/kg |
| Administration: | Oral, single dose |
| Result: | Showed 55.7 ± 0.019% inhibition on carrageenan induced rat paw edema at the 3rd h. |
| Animal Model: | Albino mice, acetic acid induced writhing method[1] |
| Dosage: | 200 mg/kg |
| Administration: | Oral, single dose |
| Result: | Showed 48.1% analgesic activity. |
References
[1] Ronad PM, et al. Synthesis and evaluation of anti-inflammatory and analgesic activities of a novel series of substituted-N-(4-methyl-2-oxo-2H-chromen-7-yl) benzamides. Arzneimittelforschung. 2008;58(12):641-6. DOI:10.1055/s-0031-1296565
Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro- Preparation Products And Raw materials
Raw materials
Preparation Products
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Benzamide, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-nitro- Suppliers
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