6-Fluoroquinoline
- Product Name
- 6-Fluoroquinoline
- CAS No.
- 396-30-5
- Chemical Name
- 6-Fluoroquinoline
- Synonyms
- 6-Fluoroquinoine;6-Fluoroquinolin;6-Fluoroquinoline;6-Fluoroquinoline>Quinoline, 6-fluoro-
- CBNumber
- CB41075579
- Molecular Formula
- C9H6FN
- Formula Weight
- 147.15
- MOL File
- 396-30-5.mol
6-Fluoroquinoline Property
- Boiling point:
- 126°C/30mmHg(lit.)
- Density
- 1.209 g/mL at 25 °C
- RTECS
- VB8370020
- refractive index
- n20/D1.592
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 4.32±0.10(Predicted)
- form
- Oil
- color
- Clear Colorless
- λmax
- 330nm(EtOH)(lit.)
N-Bromosuccinimide Price
- Product number
- 763616
- Product name
- 6-Fluoroquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $52.8
- Updated
- 2023/06/20
- Product number
- F1034
- Product name
- 6-Fluoroquinoline
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- F1034
- Product name
- 6-Fluoroquinoline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $193
- Updated
- 2025/07/31
- Product number
- F596125
- Product name
- 6-Fluoroquinoline
- Packaging
- 10g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 073644
- Product name
- 6-Fluoroquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
6-Fluoroquinoline Chemical Properties,Usage,Production
Uses
6-Fluoroquinoline, is a versatile building block used in the synthesis of various chemical compounds.
Synthesis Reference(s)
The Journal of Organic Chemistry, 56, p. 7288, 1991 DOI: 10.1021/jo00026a019
Synthesis
59611-52-8
396-30-5
General procedure for the synthesis of 6-fluoroquinoline from 6-fluoro-1,2,3,4-tetrahydroquinoline: To a 10 mL round-bottomed flask fitted with a magnetic stirring bar, 6-fluoro-1,2,3,4-tetrahydroquinoline (0.5 mmol), 40 wt% toluene solution (2.2 equiv., 1.1 mmol, 0.5 mL), and a DEAD solution of CHCl3 ( 1.0 mL). The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the mixture was concentrated using a rotary evaporator. The residue was purified by column chromatography using EtOAc: hexane (1:5) as eluent to give 6-fluoroquinoline. For compounds 2f and 2m, the product spot was close to the spot of residual DEAD. To remove residual DEAD, 1 equivalent of PPh3 was added after the reaction and the reaction mixture was stirred for 10 min. Subsequently, the reaction mixture was concentrated using a rotary evaporator. The residue was purified by column chromatography using CHCl3: hexane (1:1) as eluent to give the final 6-fluoroquinoline.
References
[1] Organic Letters, 2015, vol. 17, # 18, p. 4404 - 4407
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 11, p. 3080 - 3084
[3] Angew. Chem., 2017, vol. 129, # 11, p. 3126 - 3130,5
[4] Organic Letters, 2016, vol. 18, # 24, p. 6300 - 6303
[5] Synthetic Communications, 2018, vol. 48, # 11, p. 1291 - 1298
6-Fluoroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Fluoroquinoline manufacturers
- Product
- 6-Fluoroquinoline 396-30-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- 6-Fluoroquinoline 396-30-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 6-Fluoroquinoline 396-30-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09