6-FLUORO-4-HYDROXYQUINOLINE
- Product Name
- 6-FLUORO-4-HYDROXYQUINOLINE
- CAS No.
- 391-78-6
- Chemical Name
- 6-FLUORO-4-HYDROXYQUINOLINE
- Synonyms
- BUTTPARK 13\01-64;6-FLUOROQUINOLIN-4-OL;4-Quinolinol, 6-fluoro-;6-FLUORO-4(1H)-QUINOLINONE;6-fluoro-1H-quinolin-4-one;6-FLUORO-4-HYDROXYQUINOLINE;4-HYDROXY-6-FLUOROQUINOLINE
- CBNumber
- CB5453850
- Molecular Formula
- C9H6FNO
- Formula Weight
- 163.15
- MOL File
- 391-78-6.mol
6-FLUORO-4-HYDROXYQUINOLINE Property
- Melting point:
- 221-223℃
- Boiling point:
- 317℃
- Density
- 1.366
- Flash point:
- 145℃
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 4.07±0.40(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H6FNO/c10-6-1-2-8-7(5-6)9(12)3-4-11-8/h1-5H,(H,11,12)
- InChIKey
- BYZXOYSEYWCLOK-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(F)=CC=2)C(O)=CC=1
- CAS DataBase Reference
- 391-78-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933491090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- JRD0180
- Product name
- 6-Fluoroquinolin-4-ol
- Purity
- AldrichCPR
- Packaging
- 1 g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- F596868
- Product name
- 6-Fluoroquinolin-4-ol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F596868
- Product name
- 6-Fluoroquinolin-4-ol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 5107AB
- Product name
- 6-Fluoroquinolin-4-ol
- Packaging
- 100mg
- Price
- $64
- Updated
- 2021/12/16
- Product number
- PC8235
- Product name
- 6-Fluoro-4-hydroxyquinoline
- Purity
- 98%
- Packaging
- 5g
- Price
- $71
- Updated
- 2021/12/16
6-FLUORO-4-HYDROXYQUINOLINE Chemical Properties,Usage,Production
Synthesis
2033-24-1
371-40-4
391-78-6
GENERAL STEPS: To a solution of 4-fluoroaniline (3.03 mL, 31.5 mmol, 1.0 eq.) in ethanol (30 mL) was added cyclic (sub)isopropyl malonate (Meldrum acid, 5.54 g, 38.4 mmol, 1.2 eq.) and triethyl orthoformate (12.4 mL, 74.5 mmol, 2.4 eq.), in that order. The reaction mixture was heated to reflux for 2.5 hours. Upon completion of the reaction, the mixture was cooled to 0 °C, the precipitated solid was collected by filtration and washed with cold ethanol. The dried solid was quickly added to boiling diphenyl ether (100 mL) and the reflux state was maintained for 3 minutes. Subsequently, the reaction mixture was stirred at room temperature for 30 min, petroleum ether (25 mL) was added to promote product precipitation, and the solid was collected by filtration and dried. The crude product was purified by silica gel column chromatography (eluent: EtOAc/MeOH, 95:5, v/v) to afford the target compound 6-fluoroquinolin-4-ol (2.36 g, 14.5 mmol, 46% yield). The product was analyzed (TLC, 1H NMR, 13C NMR, IR, LC-MS, HRMS and melting point determination) and confirmed to be consistent with the data reported in the literature. Ref: WO2010/123995 (2010).TLC Rf 0.41 (EtOAc/MeOH 95:5).1H NMR (400 MHz, DMSO-d6) δ (ppm): 11.90 (s, 1H, OH), 7.94 (d, J = 7.6 Hz, 1H, NCH), 7.73 (m, 1H, NCCH), 7.53 (m, 1H, NCCH). NCCH), 7.53-7.67 (m, 2H, FCCH), 6.04 (d, J = 7.3 Hz, 1H, OHCCH).13C NMR (101 MHz, DMSO-d6) δ (ppm): 159.9, 157.7, 140.0, 137.2, 127.3, 121.1, 120.8, 109.5, 108.3. 108.3. IR (neat) νmax: 2768 (br), 1594 (m) cm?1. LC-MS (ESI+) m/z: 164.1 [M + H]+, 186.1 [M + Na]+. HRMS (ESI+) m/z: Calculated value 164.0506, measured value 164.0509 [M + H]+. Melting point: 227-228 °C.
References
[1] Patent: WO2017/21319, 2017, A1. Location in patent: Page/Page column 31
[2] Patent: WO2008/152603, 2008, A1. Location in patent: Page/Page column 36
6-FLUORO-4-HYDROXYQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-FLUORO-4-HYDROXYQUINOLINE manufacturers
- Product
- 4-Hydroxy-6-fluoroquinoline 391-78-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 6-FLUORO-4-HYDROXYQUINOLINE 391-78-6
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10