6-Fluorochromane-2-carboxylic acid
- Product Name
- 6-Fluorochromane-2-carboxylic acid
- CAS No.
- 99199-60-7
- Chemical Name
- 6-Fluorochromane-2-carboxylic acid
- Synonyms
- 6-FluorochroMane-2-carboxylic;6-Fluorochroman-2-carboxylicacid;6-FLURO-3,4-DIHYDRO 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID;2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-FLUORO-3,4-DIHYDRO-;6-Fluoro-3, 4-Dihydro-2H_x0002_Benzopyran-2-Carboxylic Acid (NEBIVOLOL STEP-III);6-Fluorochromane-2-carboxylicaci;6-fluorochroma-2-carboxylic acid;6-Fluorochloro-2-carboxylic acid;6-FLUOROCHROMANE-2-CARBOXYLIC ACID;6-Fluoro-2-chromanecarboxylic acid
- CBNumber
- CB7238183
- Molecular Formula
- C10H9FO3
- Formula Weight
- 196.18
- MOL File
- 99199-60-7.mol
6-Fluorochromane-2-carboxylic acid Property
- Melting point:
- 129.2-130.3 ºC
- Boiling point:
- 358.0±42.0 °C(Predicted)
- Density
- 1.364±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.05±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C10H9FO3/c11-7-2-4-8-6(5-7)1-3-9(14-8)10(12)13/h2,4-5,9H,1,3H2,(H,12,13)
- InChIKey
- ZNJANLXCXMVFFI-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)OC2=CC=C(F)C=C2CC1
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F1086
- Product name
- 6-Fluorochroman-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $262
- Updated
- 2025/07/31
- Product number
- F1086
- Product name
- 6-Fluorochroman-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $347
- Updated
- 2025/07/31
- Product number
- F590990
- Product name
- rac-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicAcid
- Packaging
- 10g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- PC903709
- Product name
- 6-Fluorochroman-2-carboxylic Acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- 2H21-3-0A
- Product name
- 6-Fluorochroman-2-carboxylic Acid
- Purity
- 97%
- Packaging
- 5G
- Price
- $157
- Updated
- 2021/12/16
6-Fluorochromane-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Nebivolol intermediate.
Synthesis
99199-59-4
99199-60-7
General procedure for the synthesis of 6-fluorobenzodihydropyran-2-carboxylic acid from 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid: 30 g (0.144 mol) of 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid, 5 g of wet palladium-carbon (5% Pd/carbon, 50% aqueous content) and 500 mL of glacial acetic acid were placed in an autoclave. After sealing three times under nitrogen protection, the nitrogen was replaced with hydrogen. Subsequently, the hydrogen was pressurized to 2.0 MPa and the reactor was heated to 70?80°C. During the reaction, when the hydrogen pressure in the kettle dropped, the hydrogen was promptly replenished to 2.0 MPa. The reaction was considered to be completed when the reactor pressure remained stable and did not change any more within half an hour. After the reaction was completed, the hydrogen in the autoclave was released and the reaction solution was filtered to recover the Pd/C catalyst. The filtrate was concentrated under reduced pressure to recover glacial acetic acid. The remaining concentrate was poured into 30 mL of petroleum ether and heated to give a white crystalline solid. The solid was filtered and dried to give a final 25 g of white 6-fluorobenzodihydropyran-2-carboxylic acid solid in 88.4% yield and 99.8% purity.
References
[1] Patent: CN104072470, 2016, B. Location in patent: Paragraph 0060; 0061
[2] Journal of Chemical Research, 2006, # 12, p. 807 - 808
[3] Patent: US6545040, 2003, B1
[4] Patent: US4654362, 1987, A
[5] Patent: US2004/82592, 2004, A1
6-Fluorochromane-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Fluorochromane-2-carboxylic acid manufacturers
- Product
- 6-Fluorochromane-2-carboxylic acid 99199-60-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- 6-Fluorochromane-2-carboxylic acid 99199-60-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-23
- Product
- 6-Fluorochromane-2-carboxylic acid 99199-60-7
- Price
- US $32.00-1.30/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-15