ChemicalBook > CAS DataBase List > 6-FLUORO-4-HYDROXYQUINOLINE

6-FLUORO-4-HYDROXYQUINOLINE

Product Name: 6-FLUORO-4-HYDROXYQUINOLINE
CAS No.: 391-78-6
Chemical Name: 6-FLUORO-4-HYDROXYQUINOLINE
Synonyms: BUTTPARK 13\01-64;6-FLUOROQUINOLIN-4-OL;4-Quinolinol, 6-fluoro-;6-FLUORO-4(1H)-QUINOLINONE;6-fluoro-1H-quinolin-4-one;6-FLUORO-4-HYDROXYQUINOLINE;4-HYDROXY-6-FLUOROQUINOLINE
CBNumber: CB5453850
Molecular Formula: C9H6FNO
Formula Weight: 163.15
MOL File: 391-78-6.mol

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6-FLUORO-4-HYDROXYQUINOLINE Property

Melting point:: 221-223℃
Boiling point:: 317℃
Density: 1.366
Flash point:: 145℃
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 4.07±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C9H6FNO/c10-6-1-2-8-7(5-6)9(12)3-4-11-8/h1-5H,(H,11,12)
InChIKey: BYZXOYSEYWCLOK-UHFFFAOYSA-N
SMILES: N1C2C(=CC(F)=CC=2)C(O)=CC=1
CAS DataBase Reference: 391-78-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933491090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0180
Product name: 6-Fluoroquinolin-4-ol
Purity: AldrichCPR
Packaging: 1 g
Price: $216
Updated: 2025/07/31

TRC

Product number: F596868
Product name: 6-Fluoroquinolin-4-ol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: F596868
Product name: 6-Fluoroquinolin-4-ol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 5107AB
Product name: 6-Fluoroquinolin-4-ol
Packaging: 100mg
Price: $64
Updated: 2021/12/16

Apolloscientific

Product number: PC8235
Product name: 6-Fluoro-4-hydroxyquinoline
Purity: 98%
Packaging: 5g
Price: $71
Updated: 2021/12/16

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6-FLUORO-4-HYDROXYQUINOLINE Chemical Properties,Usage,Production

Synthesis

2033-24-1

371-40-4

391-78-6

GENERAL STEPS: To a solution of 4-fluoroaniline (3.03 mL, 31.5 mmol, 1.0 eq.) in ethanol (30 mL) was added cyclic (sub)isopropyl malonate (Meldrum acid, 5.54 g, 38.4 mmol, 1.2 eq.) and triethyl orthoformate (12.4 mL, 74.5 mmol, 2.4 eq.), in that order. The reaction mixture was heated to reflux for 2.5 hours. Upon completion of the reaction, the mixture was cooled to 0 °C, the precipitated solid was collected by filtration and washed with cold ethanol. The dried solid was quickly added to boiling diphenyl ether (100 mL) and the reflux state was maintained for 3 minutes. Subsequently, the reaction mixture was stirred at room temperature for 30 min, petroleum ether (25 mL) was added to promote product precipitation, and the solid was collected by filtration and dried. The crude product was purified by silica gel column chromatography (eluent: EtOAc/MeOH, 95:5, v/v) to afford the target compound 6-fluoroquinolin-4-ol (2.36 g, 14.5 mmol, 46% yield). The product was analyzed (TLC, 1H NMR, 13C NMR, IR, LC-MS, HRMS and melting point determination) and confirmed to be consistent with the data reported in the literature. Ref: WO2010/123995 (2010).TLC Rf 0.41 (EtOAc/MeOH 95:5).1H NMR (400 MHz, DMSO-d6) δ (ppm): 11.90 (s, 1H, OH), 7.94 (d, J = 7.6 Hz, 1H, NCH), 7.73 (m, 1H, NCCH), 7.53 (m, 1H, NCCH). NCCH), 7.53-7.67 (m, 2H, FCCH), 6.04 (d, J = 7.3 Hz, 1H, OHCCH).13C NMR (101 MHz, DMSO-d6) δ (ppm): 159.9, 157.7, 140.0, 137.2, 127.3, 121.1, 120.8, 109.5, 108.3. 108.3. IR (neat) νmax: 2768 (br), 1594 (m) cm?1. LC-MS (ESI+) m/z: 164.1 [M + H]+, 186.1 [M + Na]+. HRMS (ESI+) m/z: Calculated value 164.0506, measured value 164.0509 [M + H]+. Melting point: 227-228 °C.

References

[1] Patent: WO2017/21319, 2017, A1. Location in patent: Page/Page column 31
[2] Patent: WO2008/152603, 2008, A1. Location in patent: Page/Page column 36

6-FLUORO-4-HYDROXYQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-FLUORO-4-HYDROXYQUINOLINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Hydroxy-6-fluoroquinoline 391-78-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Career Henan Chemical Co

Product: 6-FLUORO-4-HYDROXYQUINOLINE 391-78-6
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-10

391-78-6, 6-FLUORO-4-HYDROXYQUINOLINERelated Search:

6-Fluorochromane-2-carboxylic acid 6-Fluoroquinoline 6-fluoroquinoline-3-carbaldehyde 6-fluoroquinoline-2-carboxylic acid 6-FLUOROQUINOLINE-3-CARBOXYLIC ACID 6-FLUOROQUINOLINE-2-CARBOXALDEHYDE 6-Fluoroquinoline-3-carboxylic acid ethyl ester 8-FLUORO-4-HYDROXYQUINOLINE Ethyl 6,7-difluoro-2-ethylmercapto-4-hydroxyquinoline-3-carboxylate ETHYL 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE,6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Methyl 7-chloro-8-fluoro-4-hydroxyquinoline-2-carboxylate METHYL 6,8-DIFLUORO-4-HYDROXYQUINOLINE-2-CARBOXYLATE 7-FLUORO-4-HYDROXYQUINOLINE 8-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER,ETHYL 8-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE 8-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Methyl 8-fluoro-4-hydroxyquinoline-2-carboxylate 5-FLUORO-8-HYDROXYQUINOLINE,5-Fluoro-8-hydroxyquinoline99%,5-Fluoro-8-hydroxyquinoline 99%

4-HYDROXY-6-FLUOROQUINOLINE

6-FLUOROQUINOLIN-4-OL

6-FLUORO-4(1H)-QUINOLINONE

6-FLUORO-4-HYDROXYQUINOLINE

BUTTPARK 13\01-64

6-fluoro-1H-quinolin-4-one

4-Quinolinol, 6-fluoro-

391-78-6

Quinoline&Isoquinoline

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