Fendosal

Product Name: Fendosal
CAS No.: 53597-27-6
Chemical Name: Fendosal
Synonyms: hp129;CS-86;alnovin;FENDOSAL;Fendozal;P 71-0129;5-(4,5-dihydro-2-phenyl-3h-benz[e]indol-3-yl)salicylic acid;2-hydroxy-5-{2-phenyl-3H,4H,5H-benzo[e]indol-3-yl}benzoic acid;3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz[e]indole;5-(4,5-dihydro-2-phenyl-3h-benz(e)indol-3-yl)-2-hydroxybenzoicacid
CBNumber: CB4107778
Molecular Formula: C25H19NO3
Formula Weight: 381.42
MOL File: 53597-27-6.mol

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Fendosal Property

Melting point:: 223-225° (dec)
Boiling point:: 508.82°C (rough estimate)
Density: 1.2182 (rough estimate)
refractive index: 1.6000 (estimate)
pka: 2.40±0.10(Predicted)
CAS DataBase Reference: 53597-27-6(CAS DataBase Reference)

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Safety

Toxicity: LD50 in mice, rats, rabbits (mg/kg): 740, 450, 560 orally; in mice (mg/kg): 510 i.p. (Lassman)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0010526
Product name: 2-HYDROXY-5-(2-PHENYL-4,5-DIHYDRO-BENZO[E]INDOL-3-YL)-BENZOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $500.03
Updated: 2021/12/16

AK Scientific

Product number: P028
Product name: Fendosal
Packaging: 250mg
Price: $677
Updated: 2021/12/16

Matrix Scientific

Product number: 090375
Product name: 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)-salicylic acid
Purity: 95+%
Packaging: 250mg
Price: $765
Updated: 2021/12/16

Matrix Scientific

Product number: 090375
Product name: 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)-salicylic acid
Purity: 95+%
Packaging: 1g
Price: $1425
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010526
Product name: 2-HYDROXY-5-(2-PHENYL-4,5-DIHYDRO-BENZO[E]INDOL-3-YL)-BENZOIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1575
Updated: 2021/12/16

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Fendosal Chemical Properties,Usage,Production

Originator

Alnovin,Hoechst

Uses

Anti-inflammatory.

Definition

ChEBI: Fendosal is a benzoindole that is 4,5-dihydro-3H-benzo[e]indole in which the nitrogen is substituted by a 3-carboxy-4-hydroxyphenyl group. A non-narcotic analgesic and non-steroidal anti-inflammatory drug, it has greater analgesic and inflammatory responses than aspirin but with less gastrointestinal toxicity. It has a role as a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a member of pyrroles, a benzoindole and a monohydroxybenzoic acid.

Manufacturing Process

To a stirred refluxing solution of 20.2 g (0.1 mole) of 1-(1-pyrrolidino)-3,4- dihydronaphthalene and 50 ml of toluene was added dropwise during 30 minutes under nitrogen a solution of 20.1 g (0.1 mole) of phenacyl bromide in 65 ml of dry toluene. The mixture was heated under reflux for 6 hours, diluted with 50 ml of water, refluxed for 4 hours, and cooled. The layers were separated and the aqueous phase was extracted with benzene. The organic solution was dried over sodium sulfate and concentrated to a semi-solid. Trituration with cold 30°-60° petroleum ether gave 23.6 g (78%) of solid, 2- phenacyl-1-tetralone, MP: 73°-76°C. Recrystallization from 60°-90° petroleum ether raised the melting point to 87°-88°C.
A mixture of 20.0 g (0.076 mole) of 2-phenacyl-1-tetralone, 11.6 g (0.076 mole) of 5-aminosalicyclic acid, and 70 ml of glacial acetic acid was heated under reflux for 4 hours, cooled, diluted with 10 ml of water and filtered. The filter cake was washed with water and dried to provide 15.5 g of solid, 5-(4,5- dihydro-2-phenyl-3H-benz[e]indol-3-yl)-2-hydroxy-benzoic acid. MP: 215°- 218°C. Recristallization from benzene-cyclohexane gave 6.5 g (22%) of yellow crystals, MP: 245°-247°C.

brand name

Alnovin(Hoechst-Roussel).

Therapeutic Function

Analgesic, Antiinflammatory, Antipyretic

Fendosal Preparation Products And Raw materials

Raw materials

Preparation Products

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Fendosal Suppliers

China 28 Europe 2 Germany 1 United Kingdom 2 United States 13 Global 46

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53597-27-6, FendosalRelated Search:

PHENYL VALERATE Indometacin Salicylic acid cis-Octahydroisoindole Indole-3-butyric acid Indole-3-acetic acid Dihydromyrcenol Domiphen bromide Phenylacetic acid 3-(1H-PYRROL-1-YL)BENZOIC ACID 3-(1H-PYRROL-1-YL)BENZALDEHYDE [3-(1H-PYRROL-1-YL)PHENYL]METHANOL 3-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid 2,4-Diphenylpyrrole 2-HYDROXY-5-(1 H-PYRROL-1-YL)BENZOIC ACID Fendosal

hp129

5-(4,5-dihydro-2-phenyl-3h-benz[e]indol-3-yl)salicylic acid

Fendozal

P 71-0129

2-hydroxy-5-{2-phenyl-3H,4H,5H-benzo[e]indol-3-yl}benzoic acid

2-Hydroxy-5-(2-phenyl-4,5-dihydro-3H-benzo[e]indol-3-yl)benzoic acid

FENDOSAL

3-(3-carboxy-4-hydroxyphenyl)-2-phenyl-4,5-dihydro-3h-benz(e)indole

5-(4,5-dihydro-2-phenyl-3h-benz(e)indol-3-yl)-2-hydroxy-benzoicaci

5-(4,5-dihydro-2-phenyl-3h-benz(e)indol-3-yl)-2-hydroxybenzoicacid

alnovin

3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz[e]indole

CS-86

Benzoic acid, 5-(4,5-dihydro-2-phenyl-3H-benz[e]indol-3-yl)-2-hydroxy-

53597-27-6

C25H19NO3