ChemicalBook > CAS DataBase List > NPX809
NPX809
- Product Name
- NPX809
- CAS No.
- 1693734-80-3
- Chemical Name
- NPX809
- Synonyms
- NPX800;NPX809;NXP-800;NPX800 ，E1208;NPX800, 10 mM in DMSO;NXP-800,Heat shock proteins,NXP 800,inhibit,NXP800,CCT-361814,HSP,Inhibitor,CCT 361814;N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-fluorophenyl]-2-[(4-ethylpiperazin-1-yl)methyl]quinoline-6-carboxamide;N-(5-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1-yl)methyl)quinoline-6-carboxamide;6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-fluorophenyl]-2-[(4-ethyl-1-piperazinyl)methyl]-
- CBNumber
- CB410819294
- Molecular Formula
- C32H32FN5O4
- Formula Weight
- 569.63
- MOL File
- 1693734-80-3.mol
More
Less
NPX809 Property
- Boiling point:
- 612.2±55.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (175.55 mM; Need ultrasonic)
- pka
- 11.46±0.70(Predicted)
- form
- Solid
- color
- Light yellow to green yellow
- InChIKey
- UBALMDIKIGDHJW-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(C(NC3=CC(NC(C4=CC=C5OCCOC5=C4)=O)=CC=C3F)=O)=CC=2)C=CC=1CN1CCN(CC)CC1
More
Less
NPX809 Chemical Properties,Usage,Production
Uses
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 hasthepotentialforcancer research[1][2].
Biological Activity
NXP800 (CCT361814) is a potent heat shock factor 1 (HSF1) inhibitor. NXP800 has the potential for cancer research[1]. NXP800 (example 169) inhibits U20S cells viability (IC50=0.056 μM)[1].
in vivo
NXP800 (35 mg/kg; po; once daily for 20 days) inhibits the established SK-OV-3 human ovarian cancer solid tumor xenografts grown subcutaneously, with tumor growth inhibition (TGI) of 120% relative to control[2].
Pharmacokinetic Analysis[2]
| Species | Route | Dose (mg/kg) | Tmax (h) | AUClast (ng·h/mL) | Cltb (mL/min/kg) | t1/2 (h) | F (%) | AUCu0-t (h·nM) | Free Cav0-24h (nM) | Clu (mL/min/kg) |
| mouse | po/iv | 5/5 | 2.0 | 6000 (7800-4600) (po) | 10 (10-9.7) (iv) | 4.0 | 42 (po) | 72 | 3.3 | 830 (iv) |
| rat | po/iv | 5/1 | 6.0 | 2600 (po) | 24 (iv) | 3.1 | 45 (po) | 86 | 3.7 | 730 (iv) |
| dog | po/iv | 2.5/0.5 | 2.0 | 250 (po) | 21 (iv) | 1.4 | 9.1 (po) | 35 | 1.9 | 150 (iv) |
IC 50
HSF1
References
[1]. Keith Jones, et al. Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1. WO2015049535A1.
NPX809 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
NPX809 Suppliers
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 1112
- Advantage
- 64
- Tel
- 18149758185 18149758185;
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3505
- Advantage
- 58
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4800
- Advantage
- 55
- Tel
- 028-86040038 13980902949;
- Fax
- 028-85149890
- market@dingdangchem.com
- Country
- China
- ProdList
- 1854
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2961
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9531
- Advantage
- 58
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 10408
- Advantage
- 58
- Tel
- +86-027-6552-2453
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 727
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32470
- Advantage
- 58