ChemicalBook > CAS DataBase List > NPX809

NPX809

Product Name
NPX809
CAS No.
1693734-80-3
Chemical Name
NPX809
Synonyms
NPX800;NPX809;NXP-800;NPX800 ，E1208;NPX800, 10 mM in DMSO;NXP-800,Heat shock proteins,NXP 800,inhibit,NXP800,CCT-361814,HSP,Inhibitor,CCT 361814;N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-fluorophenyl]-2-[(4-ethylpiperazin-1-yl)methyl]quinoline-6-carboxamide;N-(5-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1-yl)methyl)quinoline-6-carboxamide;6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-fluorophenyl]-2-[(4-ethyl-1-piperazinyl)methyl]-
CBNumber
CB410819294
Molecular Formula
C32H32FN5O4
Formula Weight
569.63
MOL File
1693734-80-3.mol
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NPX809 Property

Boiling point:
612.2±55.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (175.55 mM; Need ultrasonic)
pka
11.46±0.70(Predicted)
form 
Solid
color 
Light yellow to green yellow
InChIKey
UBALMDIKIGDHJW-UHFFFAOYSA-N
SMILES
N1C2C(=CC(C(NC3=CC(NC(C4=CC=C5OCCOC5=C4)=O)=CC=C3F)=O)=CC=2)C=CC=1CN1CCN(CC)CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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NPX809 Chemical Properties,Usage,Production

Uses

NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 hasthepotentialforcancer research[1][2].

Biological Activity

NXP800 (CCT361814) is a potent heat shock factor 1 (HSF1) inhibitor. NXP800 has the potential for cancer research[1]. NXP800 (example 169) inhibits U20S cells viability (IC50=0.056 μM)[1].

in vivo

NXP800 (35 mg/kg; po; once daily for 20 days) inhibits the established SK-OV-3 human ovarian cancer solid tumor xenografts grown subcutaneously, with tumor growth inhibition (TGI) of 120% relative to control[2].

Pharmacokinetic Analysis[2]

SpeciesRouteDose (mg/kg)Tmax (h)AUClast (ng·h/mL)Cltb (mL/min/kg)t1/2 (h)F (%)AUCu0-t (h·nM)Free Cav0-24h (nM)Clu (mL/min/kg)
mousepo/iv5/52.06000 (7800-4600) (po)10 (10-9.7) (iv)4.042 (po)723.3830 (iv)
ratpo/iv5/16.02600 (po)24 (iv)3.145 (po)863.7730 (iv)
dogpo/iv2.5/0.52.0250 (po)21 (iv)1.49.1 (po)351.9150 (iv)

IC 50

HSF1

References

[1]. Keith Jones, et al. Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1. WO2015049535A1.

NPX809 Preparation Products And Raw materials

Raw materials

Preparation Products

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NPX809 Suppliers

China 48 United States 2 Global 50
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1136
Advantage
64
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185;
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4810
Advantage
55
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Fax
028-85149890
Email
market@dingdangchem.com
Country
China
ProdList
1854
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71615
Advantage
60
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2964
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9025
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
9945
Advantage
58
Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32469
Advantage
58

1693734-80-3, NPX809Related Search:


  • NPX809
  • NPX800
  • NXP-800
  • NXP-800,Heat shock proteins,NXP 800,inhibit,NXP800,CCT-361814,HSP,Inhibitor,CCT 361814
  • 6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-fluorophenyl]-2-[(4-ethyl-1-piperazinyl)methyl]-
  • NPX800, 10 mM in DMSO
  • N-(5-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1-yl)methyl)quinoline-6-carboxamide
  • NPX800 ，E1208
  • N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-fluorophenyl]-2-[(4-ethylpiperazin-1-yl)methyl]quinoline-6-carboxamide
  • 1693734-80-3