ChemicalBook > CAS DataBase List > 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)

1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)

Product Name: 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)
CAS No.: 366453-21-6
Chemical Name: 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)
Synonyms: 4-hydroxyisoindolin-1-one;4-Hydroxy-2,3-dihydroisoindol-1-one;2,3-Dihydro-4-hydroxy-1H-isoindol-1-one;1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy-;1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI);2,3-Dihydro-4-hydroxy-1H-isoindol-1-one, 2,3-Dihydro-4-hydroxy-1-oxo-1H-isoindole
CBNumber: CB41087657
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 366453-21-6.mol

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1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI) Property

Boiling point:: 476.5±45.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 9.01±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2925199590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: H764520
Product name: 4-Hydroxyisoindolin-1-one
Packaging: 100mg
Price: $265
Updated: 2021/12/16

AK Scientific

Product number: Z4657
Product name: 4-Hydroxy-2,3-dihydroisoindol-1-one
Packaging: 250mg
Price: $89
Updated: 2021/12/16

AK Scientific

Product number: Z4657
Product name: 4-Hydroxy-2,3-dihydroisoindol-1-one
Packaging: 5g
Price: $394
Updated: 2021/12/16

Apolloscientific

Product number: OR305268
Product name: 4-Hydroxyisoindolin-1-one
Packaging: 250mg
Price: $433
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0383216
Product name: 4-HYDROXYISOINDOLIN-1-ONE
Purity: 95.00%
Packaging: 5MG
Price: $502.47
Updated: 2021/12/16

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1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI) Chemical Properties,Usage,Production

Synthesis

366453-22-7

366453-21-6

Step c: 4-Methoxyisoindolin-1-one (291 mg, 1.78 mmol) was dissolved in dichloromethane (20 mL) and cooled in an ice bath. A 1.0 M solution of boron tribromide in dichloromethane (3.6 mL, 3.6 mmol) was added slowly with stirring. The ice bath was removed and the reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was carefully quenched by the addition of water and the mixture was extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 4-hydroxy-isoindolin-1-one (232 mg, 87% yield) as a beige solid.

References

[1] Patent: WO2004/26875, 2004, A1. Location in patent: Page 38
[2] Patent: US2004/106791, 2004, A1. Location in patent: Page 9
[3] Chinese Chemical Letters, 2012, vol. 23, # 1, p. 9 - 12

1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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366453-21-6, 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)Related Search:

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1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)

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1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy-

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366453-21-6

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