1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)
- Product Name
- 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)
- CAS No.
- 366453-21-6
- Chemical Name
- 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)
- Synonyms
- 4-hydroxyisoindolin-1-one;4-Hydroxy-2,3-dihydroisoindol-1-one;2,3-Dihydro-4-hydroxy-1H-isoindol-1-one;1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy-;1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI);2,3-Dihydro-4-hydroxy-1H-isoindol-1-one, 2,3-Dihydro-4-hydroxy-1-oxo-1H-isoindole
- CBNumber
- CB41087657
- Molecular Formula
- C8H7NO2
- Formula Weight
- 149.15
- MOL File
- 366453-21-6.mol
1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI) Property
- Boiling point:
- 476.5±45.0 °C(Predicted)
- Density
- 1.362±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 9.01±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2925199590
N-Bromosuccinimide Price
- Product number
- H764520
- Product name
- 4-Hydroxyisoindolin-1-one
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- Z4657
- Product name
- 4-Hydroxy-2,3-dihydroisoindol-1-one
- Packaging
- 5g
- Price
- $394
- Updated
- 2021/12/16
- Product number
- OR305268
- Product name
- 4-Hydroxyisoindolin-1-one
- Packaging
- 250mg
- Price
- $433
- Updated
- 2021/12/16
- Product number
- Z4657
- Product name
- 4-Hydroxy-2,3-dihydroisoindol-1-one
- Packaging
- 250mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- CHM0383216
- Product name
- 4-HYDROXYISOINDOLIN-1-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.47
- Updated
- 2021/12/16
1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI) Chemical Properties,Usage,Production
Synthesis
366453-22-7
366453-21-6
Step c: 4-Methoxyisoindolin-1-one (291 mg, 1.78 mmol) was dissolved in dichloromethane (20 mL) and cooled in an ice bath. A 1.0 M solution of boron tribromide in dichloromethane (3.6 mL, 3.6 mmol) was added slowly with stirring. The ice bath was removed and the reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was carefully quenched by the addition of water and the mixture was extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 4-hydroxy-isoindolin-1-one (232 mg, 87% yield) as a beige solid.
References
[1] Patent: WO2004/26875, 2004, A1. Location in patent: Page 38
[2] Patent: US2004/106791, 2004, A1. Location in patent: Page 9
[3] Chinese Chemical Letters, 2012, vol. 23, # 1, p. 9 - 12
1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI) Suppliers
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