AMANTANIUM BROMIDE
- Product Name
- AMANTANIUM BROMIDE
- CAS No.
- 58158-77-3
- Chemical Name
- AMANTANIUM BROMIDE
- Synonyms
- Amantanil bromidum;AMANTANIUM BROMIDE;inhibit,Amantanium bromide,Amantanium,Inhibitor
- CBNumber
- CB41093142
- Molecular Formula
- C25H46BrNO2
- Formula Weight
- 472.54224
- MOL File
- 58158-77-3.mol
AMANTANIUM BROMIDE Property
- Melting point:
- 182-184°
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
Safety
- Toxicity
- LD50 orally in mice: 910 mg/kg (Rovati)
N-Bromosuccinimide Price
- Product number
- API0016737
- Product name
- AMANTANIUM BROMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.02
- Updated
- 2021/12/16
AMANTANIUM BROMIDE Chemical Properties,Usage,Production
Description
Amantanium bromide is a quaternary ammonium antibacterial/antifugal agent useful as a surgical antiseptic and for the topical therapy of mucous and cutaneous infections. It appears somewhat more effective than cetylpyridinium chloride and benzalkonium chloride.
Originator
Rotta Research (Italy)
Manufacturing Process
A solution of 21.7 g (0.11 mole) 1-adamantanecarboxylic acid chloride in 100
ml ether was added to a solution of 19.4 g (0.22 mole) 2-
dimethylaminoethanol in 200 ml ether. The reaction mixture was stirred
overnight at room temperature. Then additional 15.0 g (0.17 mole) 2-
dimethylaminoethanol was added and the reaction mixture again stirred
overnight. The reaction mixture was poured into 300 ml water and treated
with 20 ml of 10% NaOH solution. From the ether layer was recovered 23.0 g
of 2-dimethylaminoethyl 1-adamantanecarboxylate as oil.
The 2-dimethylaminoethyl 1-adamantanecarboxylate was mixed with 1-
bromodecan and allowed to stand for about 6 weeks. The resultant crystalline
mass was washed with ether and dried to gave 2-(1’-
adamantanecarbonyloxy)ethyldimethyldecylammonium bromide as white
crystals, melting point 183°-184.5°C (two recrystallizations from ethyl
acetate).
brand name
AMANTOL
Therapeutic Function
Antiseptic
AMANTANIUM BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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