15(S)-HETRE

Product Name: 15(S)-HETRE
CAS No.: 92693-02-2
Chemical Name: 15(S)-HETRE
Synonyms: 15(S)-HETRE;15(S) HETrE,15(S)HETrE;IUKXMNDGTWTNTP-OAHXIXLCSA-N;15S-HYDROXY-8Z,11Z,13E-EICOSATRIENOIC ACID;15(S)-HYDROXYEICOSA-8Z, 11Z, 13E-TRIENOIC ACID;8,11,13-Eicosatrienoic acid, 15-hydroxy-, (8Z,11Z,13E,15S)-
CBNumber: CB4110282
Molecular Formula: C20H34O3
Formula Weight: 322.48
MOL File: 92693-02-2.mol

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15(S)-HETRE Property

Boiling point:: 487.4±40.0 °C(Predicted)
Density: 0.971±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
pka: 4.77±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 36720
Product name: 15(S)-HETrE
Purity: ≥98%
Packaging: 25μg
Price: $79
Updated: 2024/03/01

Cayman Chemical

Product number: 36720
Product name: 15(S)-HETrE
Purity: ≥98%
Packaging: 50μg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 36720
Product name: 15(S)-HETrE
Purity: ≥98%
Packaging: 100μg
Price: $280
Updated: 2024/03/01

Cayman Chemical

Product number: 36720
Product name: 15(S)-HETrE
Purity: ≥98%
Packaging: 500μg
Price: $623
Updated: 2024/03/01

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15(S)-HETRE Chemical Properties,Usage,Production

Description

15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid (DGLA; ). It is an inhibitor of 5-LO in human PMNL with an IC₅₀ value of 4.6 μM.¹ In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.²

References

1. Petrich, K., Ludwig, P., Kühn, H., et al. The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leukocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: Structure-activity relationship and mechanism of action Biochem. J. 314,911-916(1996).
2. Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues J. Med. Chem. 30(2),254-263(1987).

15(S)-HETRE Preparation Products And Raw materials

Raw materials

Preparation Products

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92693-02-2, 15(S)-HETRERelated Search:

IUKXMNDGTWTNTP-OAHXIXLCSA-N

15(S)-HETRE

15S-HYDROXY-8Z,11Z,13E-EICOSATRIENOIC ACID

15(S)-HYDROXYEICOSA-8Z, 11Z, 13E-TRIENOIC ACID

15(S) HETrE,15(S)HETrE

8,11,13-Eicosatrienoic acid, 15-hydroxy-, (8Z,11Z,13E,15S)-

92693-02-2