ChemicalBook > CAS DataBase List > 1-(2-BROMOETHOXY)-4-FLUOROBENZENE

1-(2-BROMOETHOXY)-4-FLUOROBENZENE

Product Name
1-(2-BROMOETHOXY)-4-FLUOROBENZENE
CAS No.
332-48-9
Chemical Name
1-(2-BROMOETHOXY)-4-FLUOROBENZENE
Synonyms
AKOS BC-2656;ASISCHEM Z95334;β-Bromo-4-fluorophenetole;4-FLUOROPHENOXY-ETHYLBROMIDE;beta-Bromo-4-fluorophenetole;(P-FLUOROPHENOXY)ETHYLBROMIDE;β-Bromo-4-fluorophenetole >4-(2-BROMOETHOXY)FLUOROBENZENE;2-(4-FLUOROPHENOXY)ETHYL BROMIDE;4-Fluorophenoxy-ethylbromide,95%
CBNumber
CB4110439
Molecular Formula
C8H8BrFO
Formula Weight
219.05
MOL File
332-48-9.mol
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1-(2-BROMOETHOXY)-4-FLUOROBENZENE Property

Melting point:
58-60 °C
Boiling point:
66°C/0.1mmHg(lit.)
Density 
1.4901 (rough estimate)
refractive index 
1.53-1.532
storage temp. 
Storage temp. 2-8°C
form 
Liquid After Melting
color 
Clear colorless to brownish
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-52-22
Safety Statements 
24/25
HazardClass 
IRRITANT
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4376
Product name
β-Bromo-4-fluorophenetole
Purity
>98.0%(GC)
Packaging
5g
Price
$98
Updated
2025/07/31
TCI Chemical
Product number
B4376
Product name
β-Bromo-4-fluorophenetole
Purity
>98.0%(GC)
Packaging
25g
Price
$437
Updated
2025/07/31
TRC
Product number
B750218
Product name
1-(2-Bromoethoxy)-4-fluorobenzene
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B750218
Product name
1-(2-Bromoethoxy)-4-fluorobenzene
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB80836
Product name
1-(2-Bromoethoxy)-4-fluorobenzene
Packaging
1g
Price
$60
Updated
2021/12/16
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1-(2-BROMOETHOXY)-4-FLUOROBENZENE Chemical Properties,Usage,Production

Chemical Properties

clear colorless to brownish liquid after melting

Synthesis

371-41-5

106-93-4

332-48-9

Step 2: 22.5% aqueous sodium hydroxide solution (55 mL) was slowly added to a mixed reaction flask containing 1,2-dibromoethane (112 g, 0.60 mol) and 4-fluorophenol (16.8 g, 0.15 mol). The reaction mixture was heated and stirred under reflux conditions for 5 hours. Subsequently, sodium hydroxide (3.0 g, 75 mmol) was added to the reaction system and heating and stirring were continued under reflux conditions for 5 hours. After completion of the reaction, the reaction solution was cooled to room temperature and extracted three times with dichloromethane (100 mL). The organic layers were combined, dried with anhydrous sodium sulfate and the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=10:1, v/v) to afford 1-(2-bromoethoxy)-4-fluorobenzene (compound-03) (29.7 g, 0.136 mol, 90% yield).

References

[1] Patent: EP2357165, 2011, A1. Location in patent: Page/Page column 18
[2] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 495 - 500
[3] Russian Journal of Organic Chemistry, 2000, vol. 36, # 2, p. 254 - 257
[4] Archiv der Pharmazie, 2013, vol. 346, # 3, p. 180 - 188
[5] European Journal of Medicinal Chemistry, 1992, vol. 27, # 5, p. 545 - 549

1-(2-BROMOETHOXY)-4-FLUOROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-BROMOETHOXY)-4-FLUOROBENZENE Suppliers

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332-48-9, 1-(2-BROMOETHOXY)-4-FLUOROBENZENERelated Search:

1-(2-bromoethoxy)-3-fluorobenzene 1-(2-BROMOETHOXY)-2-FLUOROBENZENE 2-(PENTAFLUOROPHENOXY)ETHYL BROMIDE 2-Phenoxyethylbromide 2-bromo-1-(2-bromoethoxy)-4-fluorobenzene 1-(2-bromoethoxy)-2,4-difluorobenzene 4-Fluorophenetole 1-(2-BROMOETHOXY)-4-FLUOROBENZENE

  • ASISCHEM Z95334
  • AKOS BC-2656
  • 4-FLUOROPHENOXY-ETHYLBROMIDE
  • 4-(2-BROMOETHOXY)FLUOROBENZENE
  • 2-(4-FLUOROPHENOXY)ETHYL BROMIDE
  • 1-BROMO-2-(4'-FLUOROPHENOXY)ETHANE
  • 1-(2-BROMOETHOXY)-4-FLUOROBENZENE
  • (P-FLUOROPHENOXY)ETHYLBROMIDE
  • p-Fluorophenoxy-ethylbromide 95%
  • 4-Fluorophenoxy-ethylbromide,95%
  • 2-(4-Fluorophenoxy)benthyl Bromide
  • 4-(2-Bromoethoxy)fluorobenzene, 1-(2-Bromoethoxy)-4-fluorobenzene, 2-Bromoethyl 4-fluorophenyl ether
  • beta-Bromo-4-fluorophenetole
  • 4-Fluorophenoxy-ethylbroMide, 95% 25GR
  • β-Bromo-4-fluorophenetole
  • 1-(2-BroMoethoxy)-4-fluorobenzene, 97+%
  • β-Bromo-4-fluorophenetole &gt
  • Benzene, 1-(2-bromoethoxy)-4-fluoro-
  • 2-Bromoethyl 4-Fluorophenyl Ether
  • 332-48-9
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Bromine Compounds
  • Fluorine Compounds