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NCNP-01

Product Name
NCNP-01
CAS No.
2055732-84-6
Chemical Name
NCNP-01
Synonyms
NS-065;NCNP-01;Viltolarsen
CBNumber
CB411075934
Formula Weight
0
MOL File
Mol file
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NCNP-01 Property

storage temp. 
Store at -20°C
form 
Solid
color 
White to off-white
Sequence
RNA, [P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-C-m5U-C-C-G-G-m5U-m5U-C-m5U-G-A-A-G-G-m5U-Gm5U-m5U-C)
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Hazard and Precautionary Statements (GHS)

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NCNP-01 Chemical Properties,Usage,Production

Uses

Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen has the potential for Duchenne muscular dystrophy (DMD) research[1][2].

References

[1] Sohita Dhillon. Viltolarsen: First Approval. Drugs. 2020 Jul;80(10):1027-1031. DOI:10.1007/s40265-020-01339-3
[2] Naoki Watanabe, et al. NS-065/NCNP-01: An Antisense Oligonucleotide for Potential Treatment of Exon 53 Skipping in Duchenne Muscular Dystrophy. Mol Ther Nucleic Acids. 2018 Dec 7:13:442-449. DOI:10.1016/j.omtn.2018.09.017

NCNP-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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2055732-84-6, NCNP-01Related Search:


  • NCNP-01
  • NS-065
  • Viltolarsen
  • 2055732-84-6