ChemicalBook > CAS DataBase List > 4-Bromo-3-chloro-6-methoxyaniline

4-Bromo-3-chloro-6-methoxyaniline

Product Name
4-Bromo-3-chloro-6-methoxyaniline
CAS No.
102170-53-6
Chemical Name
4-Bromo-3-chloro-6-methoxyaniline
Synonyms
4-Bromo-3-chloro-6-methoxyaniline;4-BroMo-5-chloro-2-Methoxyaniline;4-Bromo-5-chloro-2-methoxyaniline 95+%;Benzenamine, 4-bromo-5-chloro-2-methoxy-
CBNumber
CB41113839
Molecular Formula
C7H7BrClNO
Formula Weight
236.49
MOL File
Mol file
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4-Bromo-3-chloro-6-methoxyaniline Property

Boiling point:
296.7±35.0 °C(Predicted)
Density 
1.643±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
2.78±0.10(Predicted)
Appearance
Light brown to black Solid
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Safety

HS Code 
2921420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B679135
Product name
4-Bromo-5-chloro-2-methoxyaniline
Packaging
2.5g
Price
$140
Updated
2021/12/16
TRC
Product number
B679135
Product name
4-Bromo-5-chloro-2-methoxyaniline
Packaging
5g
Price
$250
Updated
2021/12/16
Apolloscientific
Product number
OR54520
Product name
4-Bromo-5-chloro-2-methoxyaniline
Purity
95+%
Packaging
25g
Price
$304
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-D-21
Product name
4-Bromo-5-chloro-2-methoxyaniline
Packaging
25g
Price
$360
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0358781
Product name
4-BROMO-3-CHLORO-6-METHOXY ANILINE
Purity
95.00%
Packaging
5MG
Price
$500.61
Updated
2021/12/16
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4-Bromo-3-chloro-6-methoxyaniline Chemical Properties,Usage,Production

Uses

4-Bromo-5-chloro-2-methoxyaniline is a versatile reactant used in the preparation of thiazole and thiophene derivatives as store-operated calcium channels modulators useful in treatment of SOC channel-mediated diseases.

Synthesis

95-03-4

102170-53-6

General procedure for the synthesis of 4-bromo-5-chloro-2-methoxyaniline from 4-chloro-2-aminoanisole: N-bromosuccinimide (86.7 g, 0.487 mol) was added in batches to a solution of 5-chloro-2-methoxyaniline (Intermediate 5, 76.7 g, 0.487 mol) in acetonitrile (500 mL) at 0 °C, and the addition process lasted for 2 hours. After completion of the addition, the solvent was removed by distillation under reduced pressure. The residue was purified by column chromatography (silica gel: 200-300 mesh, 200 g) with petroleum ether/ethyl acetate as eluent (ratio tapered from 20:1 to 4:1) to afford 4-bromo-5-chloro-2-methoxyaniline as a light yellow solid (40.2 g, 35% yield). The product was analyzed by LCMS (A): retention time (Rt) 1.63 min, molecular ion peak (MH+) m/z 236/238. 1H NMR (300 MHz, CDCl3) δ 6.93 (s, 1H), 6.78 (s, 1H), 3.83 (s, 3H).

References

[1] Patent: WO2015/91647, 2015, A1. Location in patent: Page/Page column 41; 42
[2] Patent: WO2016/188827, 2016, A1. Location in patent: Page/Page column 21

4-Bromo-3-chloro-6-methoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3-chloro-6-methoxyaniline Suppliers

China 52 India 3 United Kingdom 2 United States 5 Global 62
Alfa Chemistry
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+1-5166625404;
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1-516-927-0118
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United States
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Synthonix Inc
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info@synthonix.com
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SynChem，Inc
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sales@synchem.com
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SynQuest Laboratories, Inc.
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United States
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Oakwood Products, Inc.
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sales@oakwoodchemical.com
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United States
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View Lastest Price from 4-Bromo-3-chloro-6-methoxyaniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Bromo-3-chloro-6-methoxyaniline 102170-53-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06
Henan Bao Enluo International TradeCo.，LTD
Product
4-Bromo-3-chloro-6-methoxyaniline 102170-53-6
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-08-08

102170-53-6, 4-Bromo-3-chloro-6-methoxyanilineRelated Search:


  • 4-Bromo-3-chloro-6-methoxyaniline
  • 4-Bromo-5-chloro-2-methoxyaniline 95+%
  • 4-BroMo-5-chloro-2-Methoxyaniline
  • Benzenamine, 4-bromo-5-chloro-2-methoxy-
  • 102170-53-6