ChemicalBook > CAS DataBase List > (S)-3-Dimethylamino-3-phenylpropanol

(S)-3-Dimethylamino-3-phenylpropanol

Product Name
(S)-3-Dimethylamino-3-phenylpropanol
CAS No.
82769-75-3
Chemical Name
(S)-3-Dimethylamino-3-phenylpropanol
Synonyms
Dapoxetine Impurity05;Dapoxetine Impurity 49;(S)-3-Dimethylamino-3-phenylpropanol;Benzenepropanol, g-(diMethylaMino)-, (gS)-;(3S)-3-(DiMethylaMino)-3-phenyl-1-propanol;(S)-3-(diMethyl aMino)-3-phenylpropan-1-ol;Benzenepropanol, γ-(dimethylamino)-, (γS)-;(+)-(S)-3-[N,N-Dimethylamino)-3-phenylpropanol;(S)-(+)-3-N,N-dimethylamino-3-phenylpropan-1-ol
CBNumber
CB41120891
Molecular Formula
C11H17NO
Formula Weight
179.26
MOL File
82769-75-3.mol
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(S)-3-Dimethylamino-3-phenylpropanol Property

Boiling point:
281 °C
Density 
1.011
Flash point:
98 °C
storage temp. 
Sealed in dry,Room Temperature
pka
14.90±0.10(Predicted)
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Safety

HS Code 
29062990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD142888
Product name
(S)-3-Dimethylamino-3-phenylpropanol
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
W8638
Product name
(S)-3-(Dimethylamino)-3-phenylpropan-1-ol
Packaging
250mg
Price
$101
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD142888
Product name
(S)-3-Dimethylamino-3-phenylpropanol
Packaging
250mg
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD142888
Product name
(S)-3-Dimethylamino-3-phenylpropanol
Packaging
500mg
Price
$210
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD142888
Product name
(S)-3-Dimethylamino-3-phenylpropanol
Packaging
1g
Price
$363
Updated
2021/12/16
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(S)-3-Dimethylamino-3-phenylpropanol Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

(+)-(S)-3-[N,N-Dimethylamino)-3-phenylpropanol used in the preparation of 5-hydroxytryptamine reuptake inhibitors.

Synthesis

50-00-0

82769-76-4

82769-75-3

General procedure for the synthesis of (S)-3-dimethylamino-3-phenylpropanol from formaldehyde and (S)-3-amino-3-phenylpropanol: (S)-3-Amino-3-phenylpropanol (1.5 kg) prepared as above was dissolved in 1.6 kg (88%, 30 mol) of formic acid, followed by addition of 2.8 kg (37%, 35 mol) of formaldehyde solution. The reaction mixture was heated to reflux for 8 hours. Upon completion of the reaction, a burst treatment was performed followed by concentration of the reaction solution under reduced pressure. To the concentrated solution, 2 L of 7K solution was added and the pH was adjusted with 10% aqueous sodium hydroxide solution to 12. Extraction was carried out with ethyl acetate (3 L × 4) and the organic phases were combined. The organic phase was washed twice with 6 L of saturated saline, respectively. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1.65 kg of (S)-3-dimethylamino-3-phenylpropanol, which was analyzed by high-performance liquid chromatography (HPLC) with a purity of 97.36% and a yield of 93.02%. Ethyl acetate can be recovered for recycling.

References

[1] Patent: CN106883133, 2017, A. Location in patent: Paragraph 0048-0049; 0095; 0097
[2] Tetrahedron Asymmetry, 2007, vol. 18, # 17, p. 2099 - 2103
[3] Tetrahedron Asymmetry, 2006, vol. 17, # 5, p. 860 - 866
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 12, p. 2543 - 2548
[5] Tetrahedron, 2009, vol. 65, # 12, p. 2605 - 2609

(S)-3-Dimethylamino-3-phenylpropanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-3-Dimethylamino-3-phenylpropanol manufacturers

Career Henan Chemical Co
Product
(S)-3-Dimethylamino-3-phenylpropanol 82769-75-3
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100g , 1kg, 5kg , 50kg
Release date
2020-01-07

82769-75-3, (S)-3-Dimethylamino-3-phenylpropanolRelated Search:

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  • (S)-3-Dimethylamino-3-phenylpropanol
  • (S)-3-(diMethyl aMino)-3-phenylpropan-1-ol
  • (3S)-3-(DiMethylaMino)-3-phenyl-1-propanol
  • Benzenepropanol, g-(diMethylaMino)-, (gS)-
  • Dapoxetine Impurity 49
  • Benzenepropanol, γ-(dimethylamino)-, (γS)-
  • (+)-(S)-3-[N,N-Dimethylamino)-3-phenylpropanol
  • (S)-(+)-3-N,N-dimethylamino-3-phenylpropan-1-ol
  • Dapoxetine Impurity05
  • 82769-75-3