Description Uses Pharmacological action
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CHELIDONINE

Description Uses Pharmacological action
Product Name
CHELIDONINE
CAS No.
476-32-4
Chemical Name
CHELIDONINE
Synonyms
khelidonin;helidonine;CHELIDONIN;Aids002651;STYLOPHORIN;CHELIDONINE;chelidoniny;STYLOPHORON;Aids-002651;STYLOPHORINE
CBNumber
CB8347796
Molecular Formula
C20H19NO5
Formula Weight
353.37
MOL File
476-32-4.mol
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CHELIDONINE Property

Melting point:
135-140°C
alpha 
D22 +115 ±3° (ethanol); D20 +117° (c = 3 in CHCl3)
Boiling point:
bp0.002 220° (air-bath temp)
Density 
1.2976 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Sealed in dry,2-8°C
pka
14.11±0.20(Predicted)
Merck 
13,2061
InChIKey
GHKISGDRQRSCII-ZOCIIQOWSA-N
CAS DataBase Reference
476-32-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
25-20/21/22
Safety Statements 
20-45-36/37
RIDADR 
2811
WGK Germany 
3
RTECS 
FL9450000
Toxicity
LD50 in mice (mg/kg): 34.6 ±2.44 i.v. (Anderson, Chen)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
54274
Product name
Chelidonine
Purity
≥97.0% (HPLC)
Packaging
10mg-f
Price
$221
Updated
2020/08/18
Sigma-Aldrich
Product number
54274
Product name
Chelidonine
Purity
≥97.0% (HPLC)
Packaging
10 mg
Price
$230
Updated
2021/03/22
Cayman Chemical
Product number
25097
Product name
Chelidonine
Purity
≥98%
Packaging
1mg
Price
$26
Updated
2021/03/22
Cayman Chemical
Product number
25097
Product name
Chelidonine
Purity
≥98%
Packaging
5mg
Price
$117
Updated
2021/03/22
Cayman Chemical
Product number
25097
Product name
Chelidonine
Purity
≥98%
Packaging
10mg
Price
$195
Updated
2021/03/22
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CHELIDONINE Chemical Properties,Usage,Production

Description

Chelidonine, also named ranunculine, is a benzophenanthridine alkaloid isolated from the whole plant of Chelidonium majus. L. It has been used as a painkiller in clinical treatment based on its morphine-like analgesic effect. Pharmacological researches in recent years have demonstrated that chelidonine played a role in antitumor, antibacterial, spasmolysis activities, and so on. And the antitumor activity is drawing more and more attention. However, its mechanisms of function remain unclear, which needs to be clarified in the future.
Chelidonine is an alkaloid fundamental parent, a benzophenanthridine alkaloid and an alkaloid antibiotic. Chelidonine is an isolate of Papaveraceae with acetylcholinesterase and butyrylcholinesterase inhibitory activity .

Uses

Chelidonine is the major alkaloid component of Chelidonium majus. Chelidonium majus L. is the only species of the tribe Chelidonieae of the Papaveraceae family. The Papaveraceae family is rich in specific alkaloids. C. majus contains various isoquinoline alkaloids with protopine, protoberberine and benzophenanthridine structures. This benzophenanthridine alkaloid can induce apoptosis in some transformed or malignant cell lines. D-Chelidonine, the main alkaloid of Chelidonium majus, was first isolated in 1839. 
Chelidonine is a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus. Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites with a long history of investigation. A restricted number of enzyme families have been implicated in BIA metabolism. Whereas some enzymes exhibit a relatively broad substrate range, others are highly substrate specific. A small number of plant species, including opium poppy (Papaver somniferum) and other members of the Ranunculales, have emerged as model systems to study BIA metabolism. Recently, the emergence of transcriptomics, proteomics and metabolomics has expedited the discovery of new BIA biosynthetic genes.

Pharmacological action

Chelidonine is an isolate of Papaveraceae with acetylcholinesterase and butyrylcholinesterase (a nonspecific cholinesterase) inhibitory activity. AChE (acetylcholinesterase) inhibitors or anti-cholinesterases inhibit the cholinesterase enzyme from breaking down ACh, increasing both the level and duration of the neurotransmitter action. According to the mode of action, AChE inhibitors can be divided into two groups: irreversible and reversible. Reversible inhibitors, competitive or noncompetitive, mostly have therapeutic applications, while toxic effects are associated with irreversible AChE activity modulators. Reversible AChE inhibitors play an important role in pharmacological manipulation of the enzyme activity. These inhibitors include compounds with different functional groups (carbamate, quaternary or tertiary ammonium group), and have been applied in the diagnostic and/or treatment of various diseases such as: myasthenia gravis, AD, post-operative ileus, bladder distention, glaucoma, as well as antidote to anticholinergic overdose. In general, methyltransferases of BIA metabolism accept a wide variety of alkaloid substrates with diverse backbone structures, with some showing more flexibility than others with respect to substrate range.

Description

Chelidonine, also named ranunculine, is a kind of alkaloid isolated from the whole plant of Chelidonium majus. L . As a kind of traditional Chinese medicine, Chelidonium majus. L was firstly recorded in Chiu Huang Pen Ts’ao of Ming dynasty. In the seventeenth century, it has been used for the treatment of jaundice, biliary colic, and cholelithiasis. In 1941, a researcher from Soviet Union reported that it showed good effect for the treatment of cutaneous tuberculosis. This plant has multiple effects on different diseases, including anti-inflammatory, analgesia, relieving cough, inducing diuresis, anticancer, antifungal, relieving asthma, and detoxification. It was recorded in the Pharmacopoeia of the People’s Republic of China (1977) .
The material basis for Chelidonium majus. L is alkaloid. Among which, chelidonine, a benzophenanthridine alkaloid, is the main effective ingredient . Although great progresses have been made in the chemical synthesis of chelidonine recently, the biosynthetic pathways of chelidonine remain unclear, which still need in-depth study and exploration in the future

Chemical Properties

White, crystalline powder alkaloid.

Physical properties

Appearance: white crystal or crystalline powder, monoclinic prism crystal. Solubility: insoluble in water; soluble in ethanol, chloroform, and amyl alcohol. Melting point: 135–136 °C. Boiling point: 220 °C. Specific optical rotation: +115°.

History

Chelidonine was isolated from Chelidonium majus. L in 1824 for the first time. Pharmacological studies found that it exerted antitumor effect via different mechanisms. However, its poor bioavailability limited its application. Some researchers developed a chelidonine/polylactic acid copolymer nanoparticle using nanotechnology. The nano-chelidonine showed good tissue distribution without causing any toxicity in mice and could enter into the brain tissues, showing great application potential. In addition, nano-chelidonine showed protective effect on liver injury induced by cadmium in mice .
In 1981, an Austrian researcher isolated a novel compound ukrain (phosphorothioate derivative of chelidonine) from Chelidonium majus. L. Ukrain could inhibit tumor cell proliferation through a variety of mechanisms. Currently, ukrain is used as an antitumor drug for the clinical treatment of lung cancer, breast cancer, prostate cancer, and pancreatic cancer . In 2004, quarter amine chelidonine phosphorothioate derivatives have been applied for an invention patent as anticancer drugs in China.
Chelidonine has morphine-like analgesic effects suggesting that its analgesic effect is mainly peripheral and cannot be antagonized by the morphine receptor antagonist naloxone . The 6-alkoxy and 6-acyloxy derivatives of chelidonine can inhibit the central nervous system, especially for nerve terminal, and show sedative and hypnotic effects .

Uses

Poison; central nervous system depres- sant causing sleepiness, depression, slowing of the pulse, coma and circulatory failure.

Pharmacology

Chelidonine has a variety of pharmacological effects, mainly manifested in the following aspects:
1. The effect on nervous system (analgesia, sedation)
Chelidonine, as a protopine, has analgesia effect similar to that of morphine. After intragastric administration (5–20 mg/kg) to mice, it showed a dose-dependent analgesic effect, which could sustain 4–48 h . Chelidonine derivatives also have sedative and hypnotic effects .
2. The effect on cardiovascular systemChelidonine has many effects on cardiovascular system, including exciting heart, expanding coronary blood vessels, and increasing blood pressure. Chelidonine (0.01–0.02 mg) leads to the excitement of frog heart in vitro, as well as slowdown of heart beat. Higher dosage (0.05 mg) of chelidonine could cause arrhythmia and diastolic cardiac arrest .
3. The antitumor effect
Chelidonine is a toxic substance that can influence mitosis. In vitro studies have shown that chelidonine had significant inhibitory effects for gastric cancer, leukemia, nasopharyngeal carcinoma, and hepatoma carcinoma cells. It also could delay the growth of malignant tumors. Its antitumor effects were mediated by different mechanisms, which still need further studies .
4. The effect on smooth muscle
Chelidonine has spasmolytic and diastolic effects and can inhibit a variety of smooth muscle spasm. Obvious spasmolytic effects for gastrointestinal tract and bronchial and urinary system have been reported .
5. The antibacterial effect
Chelidonine has antibacterial effect. It inhibits Mycobacterium tuberculosis in vivo and inhibits alpha Streptococcus, Diplococcus pneumoniae, and other gram-positive bacteria in vitro. In addition, chelidonine also shows inhibitory effect on Kauffman-Wolf Trichophyta and Epidermophyton floccosum .
6. Other pharmacological effects
Chelidonine showed protective effects on cadmium chloride-induced liver and kidney toxicity in rats. Chelidonine can inhibit the growth of human keratinocytes. Guinea pig test confirmed that chelidonine (4–10 mg/kg) could prevent or delay the anaphylactic shock. In addition, chelidonine has anti-mite effect and good synergistic effect with trichlorfon or omethoate to prevent cotton bollworm.

Clinical Use

Chelidonine has been used as a painkiller in clinical application due to its significant analgesic effect. Chelidonine phosphate can be used for treatment of gastrointestinal and ulcer pain, as a substitute of morphine preparations. Wei Tong Shu capsule is used to treat pain caused by gastric convulsion, chronic gastritis, gastric ulcer, and duodenal ulcer. Its main effective compositions are chelidonine and protopine. Fu Fang Zhong Yao Tong An injection has collateral dredging and analgesic effects and can be used for the treatment of moderate pain caused by chemoradiotherapy or non-chemoradiotherapy of gastric cancer, lung cancer, and liver cancer. Its two main components are chelidonine and sinomenine. Ukrain (NSC-631570), a phosphorothioate derivative of chelidonine, has been used in clinical treatment as an effective antitumor drug for the treatment of lung cancer, breast cancer, prostate cancer, and pancreatic cancer.

CHELIDONINE Preparation Products And Raw materials

Raw materials

Preparation Products

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CHELIDONINE Suppliers

Chengdu Greenpure Biopharma CO.,Ltd
Tel
Email
jancyzheng@gcgreenpure.com
Country
China
ProdList
1584
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
Advantage
61
China Langchem Inc.
Tel
0086-21-58956006;021-38701807;021-58950017
Fax
0086-21-58956100
Country
China
ProdList
7833
Advantage
57
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847-
Fax
021-55068248
Email
3008007399@qq.com
Country
China
ProdList
4995
Advantage
60
Chengdu Biopurify Phytochemicals Ltd.
Tel
028-82633397-
Fax
+86-28-82633165
Email
daisy@biopurify.cn
Country
China
ProdList
2040
Advantage
60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 QQ:1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Shanghai Winherb Medical Technology Co., Ltd.
Tel
136-81877033- ;
Fax
QQ:190129269
Email
winherb@126.com;2702713455@qq.com
Country
China
ProdList
1010
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
4041
Advantage
66
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View Lastest Price from CHELIDONINE manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Chelidonine 476-32-4 476-32-4
Price
US $88.00/mg
Min. Order
20mg
Purity
≥98%
Supply Ability
1000.00 kgs
Release date
2019-07-09
Shaanxi Dideu Medichem Co. Ltd
Product
Chelidonine 476-32-4
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30
Dideu Industries Group Limited
Product
CHELIDONINE USP/EP/BP 476-32-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-16

476-32-4, CHELIDONINERelated Search:


  • chelidoniny
  • helidonine
  • khelidonin
  • STYLOPHORIN
  • STYLOPHORINE
  • STYLOPHORON
  • Chelidonine 476-32-4
  • CHELIDONIN
  • (+)-CHELIDONINE
  • CHELIDONINE
  • CHELIDONINE, (+)-
  • (+)-CHELIDONINE FREE BASE MONOHYDRATE
  • CHELIDONINE HYDROCHLORIDE, (+)-(RG)
  • 11β-Hydroxychelidonane
  • [1,3]benzodioxolo[5,6-C]-1,3-dioxolo[4,5-I]phenanthridin-6-ol, 5B,6,7,12B,13,14-hexahydro-13-methyl-, (5br,6S,12bs)-
  • 5B,6,7,12B,13,14-Hexahydro-13-methyl[1,3]benzodioxolo[5,6-C]-1,3-dioxolo[4,5-I]phenan-thridin-6-ol
  • Aids002651
  • Aids-002651
  • Benzophenanthridine alkaloid
  • Nsc646661 (free base)
  • Chelidonine, 98%, from Chelidonium majus L.
  • CHELIDONINE USP/EP/BP
  • 476-32-4
  • C20H19NO5H2O
  • C20H19NO5
  • Alkaloids