(S)-3-Dimethylamino-3-phenylpropanol
- Product Name
- (S)-3-Dimethylamino-3-phenylpropanol
- CAS No.
- 82769-75-3
- Chemical Name
- (S)-3-Dimethylamino-3-phenylpropanol
- Synonyms
- Dapoxetine Impurity05;Dapoxetine Impurity 49;(S)-3-Dimethylamino-3-phenylpropanol;Benzenepropanol, g-(diMethylaMino)-, (gS)-;(3S)-3-(DiMethylaMino)-3-phenyl-1-propanol;(S)-3-(diMethyl aMino)-3-phenylpropan-1-ol;Benzenepropanol, γ-(dimethylamino)-, (γS)-;(+)-(S)-3-[N,N-Dimethylamino)-3-phenylpropanol;(S)-(+)-3-N,N-dimethylamino-3-phenylpropan-1-ol
- CBNumber
- CB41120891
- Molecular Formula
- C11H17NO
- Formula Weight
- 179.26
- MOL File
- 82769-75-3.mol
(S)-3-Dimethylamino-3-phenylpropanol Property
- Boiling point:
- 281 °C
- Density
- 1.011
- Flash point:
- 98 °C
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.90±0.10(Predicted)
Safety
- HS Code
- 29062990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FD142888
- Product name
- (S)-3-Dimethylamino-3-phenylpropanol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W8638
- Product name
- (S)-3-(Dimethylamino)-3-phenylpropan-1-ol
- Packaging
- 250mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- FD142888
- Product name
- (S)-3-Dimethylamino-3-phenylpropanol
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FD142888
- Product name
- (S)-3-Dimethylamino-3-phenylpropanol
- Packaging
- 500mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- FD142888
- Product name
- (S)-3-Dimethylamino-3-phenylpropanol
- Packaging
- 1g
- Price
- $363
- Updated
- 2021/12/16
(S)-3-Dimethylamino-3-phenylpropanol Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
(+)-(S)-3-[N,N-Dimethylamino)-3-phenylpropanol used in the preparation of 5-hydroxytryptamine reuptake inhibitors.
Synthesis
50-00-0
82769-76-4
82769-75-3
General procedure for the synthesis of (S)-3-dimethylamino-3-phenylpropanol from formaldehyde and (S)-3-amino-3-phenylpropanol: (S)-3-Amino-3-phenylpropanol (1.5 kg) prepared as above was dissolved in 1.6 kg (88%, 30 mol) of formic acid, followed by addition of 2.8 kg (37%, 35 mol) of formaldehyde solution. The reaction mixture was heated to reflux for 8 hours. Upon completion of the reaction, a burst treatment was performed followed by concentration of the reaction solution under reduced pressure. To the concentrated solution, 2 L of 7K solution was added and the pH was adjusted with 10% aqueous sodium hydroxide solution to 12. Extraction was carried out with ethyl acetate (3 L × 4) and the organic phases were combined. The organic phase was washed twice with 6 L of saturated saline, respectively. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1.65 kg of (S)-3-dimethylamino-3-phenylpropanol, which was analyzed by high-performance liquid chromatography (HPLC) with a purity of 97.36% and a yield of 93.02%. Ethyl acetate can be recovered for recycling.
References
[1] Patent: CN106883133, 2017, A. Location in patent: Paragraph 0048-0049; 0095; 0097
[2] Tetrahedron Asymmetry, 2007, vol. 18, # 17, p. 2099 - 2103
[3] Tetrahedron Asymmetry, 2006, vol. 17, # 5, p. 860 - 866
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 12, p. 2543 - 2548
[5] Tetrahedron, 2009, vol. 65, # 12, p. 2605 - 2609
(S)-3-Dimethylamino-3-phenylpropanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-3-Dimethylamino-3-phenylpropanol manufacturers
- Product
- (S)-3-Dimethylamino-3-phenylpropanol 82769-75-3
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07