2-BROMO-1-(4-DIMETHYLAMINO-PHENYL)-ETHANONE
- Product Name
- 2-BROMO-1-(4-DIMETHYLAMINO-PHENYL)-ETHANONE
- CAS No.
- 37904-72-6
- Chemical Name
- 2-BROMO-1-(4-DIMETHYLAMINO-PHENYL)-ETHANONE
- Synonyms
- BUTTPARK 82\50-86;4-(Dimethylamino)phenacyl bromide;4-(Dimethylamino)phenacylbromide97%;2-BROMO-4'-DIMETHYLAMINOACETOPHENONE;4-(Dimethylamino)phenacyl bromide 97%;2-BROMO-1-(4-DIMETHYLAMINO-PHENYL)-ETHANONE;2-BroMo-1-[4-(diMethylaMino)phenyl]ethan-1-one;Ethanone, 2-bromo-1-[4-(dimethylamino)phenyl]-;2-Bromo-4'-(dimethylamino)acetophenone, 2-Bromo-1-[4-(dimethylamino)phenyl]ethan-1-one
- CBNumber
- CB4113692
- Molecular Formula
- C10H12BrNO
- Formula Weight
- 242.11
- MOL File
- 37904-72-6.mol
2-BROMO-1-(4-DIMETHYLAMINO-PHENYL)-ETHANONE Property
- Melting point:
- 89-92
- Boiling point:
- 330.2±22.0 °C(Predicted)
- Density
- 1.406±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Sparingly), DMSO (Slightly, Sonicated)
- form
- Solid
- pka
- 1.56±0.12(Predicted)
- color
- Yellow to Dark Yellow
Safety
- Hazard Codes
- Xi
- Hazard Note
- Harmful/Irritant/Keep Cold
- HS Code
- 2934309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS005074
- Product name
- 2-bromo-1-(4-dimethylamino-phenyl)-ethanone
- Purity
- AldrichCPR
- Packaging
- 100MG
- Price
- $66.1
- Updated
- 2025/07/31
- Product number
- B691523
- Product name
- 2-Bromo-1-(4-dimethylaminophenyl)ethanone
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR3530
- Product name
- 4-(Dimethylamino)phenacylbromide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 4656-9-Y1
- Product name
- 4-(Dimethylamino)phenacyl bromide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR3530
- Product name
- 4-(Dimethylamino)phenacylbromide
- Purity
- 97%
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
2-BROMO-1-(4-DIMETHYLAMINO-PHENYL)-ETHANONE Chemical Properties,Usage,Production
Uses
2-Bromo-1-(4-dimethylaminophenyl)ethanone can be used as potential biomarkers for respiratory illness.
Synthesis
210832-81-8
37904-72-6
The general procedure for the synthesis of 2-bromo-1-(4-(dimethylamino)phenyl)ethanone from the compound (CAS: 210832-81-8) was as follows: 5.1 g (1 eq.) of the raw material was dissolved in 30 mL of THF, and cooled to 0°C. Subsequently, a mixed solution consisting of diethyl phosphite (2.04 mL, 1 eq.) and triethylamine (2.4 mL, 1.1 eq.) in 12 mL of THF was added slowly and dropwise. The reaction mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation and the residue was poured into 200 mL of ice water. The resulting precipitate was collected by filtration, washed with water and dried under vacuum to give the green solid product 3 in 89% yield. The structure of the product was confirmed by nuclear magnetic resonance hydrogen (1H NMR, CDCl3) and carbon (13C NMR, CDCl3) spectra: 1H NMR (CDCl3) δ 2.97 (s, 6H, 2×CH3), 4.45 (s, 2H, CH2), 6.57 (d, 2H, J = 9.0 Hz, 2×CHAr), 7.72 (d, 2H, CHAr); 13C NMR (CDCl3) δ 31.3 (1C, CH2), 40.4 (2C, CH3), 111.1 (2C, CHAr), 121.8 (1C, Cq), 131.6 (2C, CHAr), 154.1 (1C, Cq), 189.7 (1C, Cq).
References
[1] Tetrahedron Letters, 1998, vol. 39, # 28, p. 4987 - 4990
[2] Patent: US2007/258887, 2007, A1. Location in patent: Page/Page column 28; 39-40
[3] Chemical Communications, 2016, vol. 52, # 90, p. 13277 - 13280
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 2966 - 2968
[5] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 7, p. 596 - 600
2-BROMO-1-(4-DIMETHYLAMINO-PHENYL)-ETHANONE Preparation Products And Raw materials
Raw materials
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