2-Bromo-1-(4-morpholinophenyl)-1-ethanone
- Product Name
- 2-Bromo-1-(4-morpholinophenyl)-1-ethanone
- CAS No.
- 210832-85-2
- Chemical Name
- 2-Bromo-1-(4-morpholinophenyl)-1-ethanone
- Synonyms
- BUTTPARK 146\50-45;2-Bromo-4'-morpholinoacetophenone;4-(Morpholin-4-yl)phenacyl bromide;2-Bromo-1-(4-morpholinophenyl)ethanone;4-(Morpholin-4-yl)phenacyl bromide 97%;2-BROMO-1-(4-MORPHOLINOPHENYL)-1-ETHANONE;2-Bromo-1-(4-morpholin-4-ylphenyl)ethanone;Ethanone, 2-bromo-1-[4-(4-morpholinyl)phenyl]-;2-broMo-1-[4-(Morpholin-4-yl)phenyl]ethan-1-one;2-Bromo-1-[4-(morpholin-4-yl)phenyl]ethan-1-one97%
- CBNumber
- CB8235093
- Molecular Formula
- C12H14BrNO2
- Formula Weight
- 284.15
- MOL File
- 210832-85-2.mol
2-Bromo-1-(4-morpholinophenyl)-1-ethanone Property
- Melting point:
- 112 °C
- storage temp.
- Keep Cold
- Sensitive
- Lachrymatory
Safety
- Hazard Codes
- C
- Risk Statements
- 36/37/38-34
- Safety Statements
- 26-36/37/39-45
- Hazard Note
- Corrosive/Lachrymatory/Keep Cold
- HS Code
- 2933299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B697910
- Product name
- 2-Bromo-1-(4-morpholinophenyl)ethanone
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- B697910
- Product name
- 2-Bromo-1-(4-morpholinophenyl)ethanone
- Packaging
- 500mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- Y8223
- Product name
- 2-Bromo-1-(4-morpholinophenyl)-1-ethanone
- Packaging
- 1g
- Price
- $197
- Updated
- 2021/12/16
- Product number
- FB158440
- Product name
- 2-Bromo-1-(4-morpholinophenyl)-1-ethanone
- Packaging
- 500mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- OR8584
- Product name
- 2-Bromo-1-[4-(morpholin-4-yl)phenyl]ethan-1-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $128
- Updated
- 2021/12/16
2-Bromo-1-(4-morpholinophenyl)-1-ethanone Chemical Properties,Usage,Production
Synthesis
1) Preparation of intermediate 4-morpholinophenylacetophenone
Take 50g of 4-fluoroacetophenone, dissolve in 350mL of dimethyl sulfoxide (DMSO) (about 7~8 times the mass volume ratio), stir well, at this time a colorless solution. Slowly add 78.8 g (0.9 mol) of morpholine dropwise at room temperature, dropwise, warm up to 120 reflux. The solution gradually changed to light yellow. The reaction was complete for 3~4h, and the end point of the reaction was monitored by TLC. When the reaction was finished, it was left to room temperature. The reaction solution was slowly poured into a large amount of ice water with stirring, and a yellow solid precipitated. Filter was drawn, the filter cake was collected, washed twice with water and dried to give 63g of yellow solid (85% yield).
(2) Intermediate 2,2-dibromo-1-(4-morpholinophenyl)ethanone preparation
30 g (0.15 mol) of 4-morpholinophenyl ethanone, 210 mL of concentrated sulfuric acid (about 7-8 times the mass to volume ratio), were added to a 500 mL three-necked flask equipped with mechanical stirring and a thermometer and stirred to dissolve. The reaction solution was cooled to 0C, at which temperature 7.8 mL of bromine was slowly dripped in to control the temperature at 0C. After dropping, the reaction was done at room temperature. The reaction was carried out for about 6h and the reaction was monitored for completeness by TLC. The reaction solution was poured into a large amount of ice water and a yellow-green solid precipitated, stirring. After the ice was dissolved, it was filtered and washed with water until neutral. The filter cake was collected and dried to give 47 g of yellow-green solid in 88% yield.
2-Bromo-1-(4-morpholinophenyl)-1-ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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