(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
- Product Name
- (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
- CAS No.
- 3462-95-1
- Chemical Name
- (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
- Synonyms
- (4-fluorophenyl)methyl-triphenylphosphanium;(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE;(4-Fluorophenylmethyl)triphenylphosphoniumchloride;4-Fluorobenzyl triphenylphosphonium chloride, 98+%;(4-fluorophenyl)methyl-triphenylphosphanium,chloride
- CBNumber
- CB4114174
- Molecular Formula
- C25H21ClFP
- Formula Weight
- 406.86
- MOL File
- 3462-95-1.mol
(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE Property
- Melting point:
- 310-312°C
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
- Sensitive
- Hygroscopic
- BRN
- 4075331
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- S774154
- Product name
- (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- S774154
- Product name
- (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
- Purity
- Aldrich
- Packaging
- 50mg
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- AK-86825
- Product name
- (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
- Purity
- 95+%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- J54059
- Product name
- (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- AK-86825
- Product name
- (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
- Purity
- 95+%
- Packaging
- 5g
- Price
- $37
- Updated
- 2021/12/16
(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE Chemical Properties,Usage,Production
Chemical Properties
white granular crystalline powder
Synthesis
603-35-0
352-11-4
3462-95-1
General method: As an example of the synthesis of trans-3a: A mixture of 4.0 g (2.78 mmol) of 4-fluorobenzyl chloride and 8.73 g (3.30 mmol) of triphenylphosphine in 12 mL of benzene was refluxed for 48 h to give a white solid. The solid was collected by filtration to give (4-fluorobenzyl)triphenylphosphonium chloride in 82% yield. Then, a mixture of 9.97 g (2.5 mmol) of the above phosphonium salt, 2.37 g (2.2 mmol) of benzaldehyde, and 0.82 g (3.11 mmol) of 18-crown-6 in 56 mL of dichloromethane was stirred vigorously and 27 mL of aqueous 50 % K2CO3 was added slowly. After the addition was completed, the reaction mixture was stirred at room temperature for 72 hours. Upon completion of the reaction, the mixture was poured into water and extracted three times with ethyl acetate. The organic layers were combined and dried with anhydrous MgSO4. The organic solvent was removed by concentration under reduced pressure and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane = 1:10) to give a mixture of cis and trans-3a in 95.1% yield. The above mixture was refluxed with a catalytic amount of iodine in benzene for 3 h. After completion of the reaction, the mixture was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1:10) to afford trans-3a in 92% yield.
References
[1] Tetrahedron, 2013, vol. 69, # 35, p. 7325 - 7332
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3041 - 3045
[3] Journal of Organic Chemistry, 1993, vol. 58, # 21, p. 5643 - 5649
[4] Medicinal Chemistry Research, 2011, vol. 20, # 8, p. 1158 - 1163
[5] Medicinal Chemistry Research, 2011, vol. 20, # 8, p. 1349 - 1356
(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE Suppliers
- Tel
- --
- Fax
- --
- info@acros.com
- Country
- Belgium
- ProdList
- 6772
- Advantage
- 81
View Lastest Price from (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE manufacturers
- Product
- (4-Fluorobenzyl)Triphenylphosphonium Chloride 3462-95-1
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2020-01-16