3-Methoxybenzyltriphenylphosphonium chloride
- Product Name
- 3-Methoxybenzyltriphenylphosphonium chloride
- CAS No.
- 18880-05-2
- Chemical Name
- 3-Methoxybenzyltriphenylphosphonium chloride
- Synonyms
- 3-Methoxybenzyltriphenyl chloride;3-METHOXYBENZYLTRIPHENYLPHOSPHONIUM CHLORIDE;(3-Methoxybenzyl)triphenylphosphoniumChloride>3-Methoxybenzyltriphenylphosphonium chloride, 98 %;[(3-Methoxyphenyl)Methyl]triphenylphosphaniuM chloride;[(3-Methoxyphenyl)methyl]triphenylphosphonium chloride;Phosphonium, [(3-methoxyphenyl)methyl]triphenyl-, chloride (1:1)
- CBNumber
- CB91473495
- Molecular Formula
- C26H24ClOP
- Formula Weight
- 418.89
- MOL File
- 18880-05-2.mol
3-Methoxybenzyltriphenylphosphonium chloride Property
- Melting point:
- 271-272 °C
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- color
- White to Almost white
Safety
- HS Code
- 2931.90.9051
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M2463
- Product name
- (3-Methoxybenzyl)triphenylphosphonium Chloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- M2463
- Product name
- (3-Methoxybenzyl)triphenylphosphonium Chloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $156
- Updated
- 2025/07/31
- Product number
- M261890
- Product name
- (3-Methoxybenzyl)triphenylphosphonium Chloride
- Packaging
- 25mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- ING0005824
- Product name
- 3-METHOXYBENZYLTRIPHENYLPHOSPHONIUM CHLORIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $535
- Updated
- 2021/12/16
- Product number
- 9840AA
- Product name
- (3-Methoxybenzyl)triphenylphosphonium Chloride
- Packaging
- 10g
- Price
- $146
- Updated
- 2021/12/16
3-Methoxybenzyltriphenylphosphonium chloride Chemical Properties,Usage,Production
Uses
(3-Methoxybenzyl)(triphenyl)phosphonium Chloride is an intermediate used in the synthesis of 2-Hydroxychrysene (H905340), which is a hydroxylated metabolite of Chrysene (C428000). Binding activity of 2-Hydroxychrysene to estrogenic receptor induces toxicity.
Synthesis
603-35-0
824-98-6
18880-05-2
Example 2: Synthesis of (3-methoxybenzyl)triphenylphosphonium chloride (Compound I, Scheme A, Intermediate) 3-Methoxybenzyl chloride (5 g, 32 mmol) and triphenylphosphonium (9.205 g, 33.93 mmol) were dissolved in acetonitrile (20 mL) and the reaction mixture was stirred under reflux conditions for 12 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting product was dissolved in a minimal amount of chloroform and subsequently precipitated by the addition of ether. The solid formed was collected by filtration to afford the target compound in 98.5% yield. 1H NMR (CDCl3): δ 3.53 (s, 3H, OCH3); 5.44 (d, 2H, J = -16Hz, CH2); 6.60-6.77 (m, 3H, Ar); 7.02 (t, 1H, J = 7.6 Hz); 7.11-7.21 (m, 15H, PPh3) ppm. Mass spectrum (m/z): [M+ -Cl] 383 (16.1%). Elemental analysis results are as expected.
References
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6607 - 6613
[2] Patent: US2009/93493, 2009, A1. Location in patent: Page/Page column 10
[3] Polymer, 2015, vol. 64, p. 202 - 209
[4] Archiv der Pharmazie, 2001, vol. 334, # 4, p. 125 - 137
[5] Archiv der Pharmazie, 1995, vol. 328, # 7-8, p. 595 - 603
3-Methoxybenzyltriphenylphosphonium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Methoxybenzyltriphenylphosphonium chloride manufacturers
- Product
- 3-Methoxybenzyltriphenylphosphonium chloride 18880-05-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-23
- Product
- 3-Methoxybenzyltriphenylphosphonium chloride 18880-05-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- (3-Methoxybenzyl)(triphenyl)phosphonium chloride 18880-05-2
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-13