ChemicalBook > CAS DataBase List > Centhaquine

Centhaquine

Product Name
Centhaquine
CAS No.
57961-90-7
Chemical Name
Centhaquine
Synonyms
PMZ-2010;Centhaquin;Centhaquine;Centhaquin PMZ-2010;TAK438 Impurity 162;Centhaquin >=98% (HPLC);Centhaquine (Centhaquin;Centhaquin, 10 mM in DMSO;Centhaquin (Centhaquine,PMZ-2010);2-(2-(4-(m-tolyl)piperazin-1-yl)ethyl)quinoline
CBNumber
CB41178241
Molecular Formula
C22H25N3
Formula Weight
331.45
MOL File
57961-90-7.mol
More
Less

Centhaquine Property

storage temp. 
Store at -20°C
solubility 
DMSO: 62.5 mg/mL (188.57 mM)
form 
Solid
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1786
Product name
Centhaquin
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$94.52
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1786
Product name
Centhaquin
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$405
Updated
2025/07/31
TRC
Product number
C256615
Product name
Centhaquin
Packaging
100mg
Price
$1540
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001987
Product name
CENTHAQUINE
Purity
95.00%
Packaging
5MG
Price
$498.01
Updated
2021/12/16
DC Chemicals
Product number
012241
Product name
Centhaquin(Centhaquine,PMZ-2010)
Packaging
003
Price
$1800
Updated
2021/12/16
More
Less

Centhaquine Chemical Properties,Usage,Production

Uses

Centhaquin is a centrally acting hypotensive drug similar to Clonidine (C587120), which is an α2 adrenergic agonist.

Biological Activity

Centhaquin is a centrally acting hypotensive agent. Centhaquin is an effective resuscitative agent th at improves cardiac output, reduces blood lactate levels, and improves survival time of hemorrhaged rats. Centhaquin exhibits antinociception in the mouse mediated through the opioid, the α2A and α2B adrenoceptors.

in vivo

Centhaquine (Centhaquin) (intravenous injection, 0.01-1.0 mg/kg; intraduodenal administration 1.0-2.5 mg/kg) lowers the blood pressure and reduced the heart rate of anaesthetized and unanaesthetized (decerebrate) cat in a dose-dependent manner[1]. Centhaquine (Centhaquin) (intravertebral arterial injection; 5-10 μg) or by topical application to the exposed ventral surface of medulla or floor of the fourth ventricle causes hypotension and bradycardia as well as reduced the excitability of the vasomotor loci[1]. Centhaquine (Centhaquin;PMZ-2010) (intravenous administration; 0.015mg/kg) can attenuate the deleterious effects of catecholamines, improving both the macro- and microcirculation during CPR[2].

Animal Model:Landrace/Large White piglets[2]
Dosage:0.015mg/kg
Administration:Intravenous administration; Adrenaline 0.02mg/kg plus Centhaquin 0.015mg/kg
Result:Added to adrenaline improved ROSC rates in a swine model of VF cardiac arrest.

Centhaquine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Centhaquine Suppliers

China 37 India 1 United States 6 Global 44
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Syntechem Co.,Ltd.
Tel
519-88298820 15861130028
Fax
86-519-83850735
Email
info@syntechem.com
Country
China
ProdList
242
Advantage
58
Guangzhou Belka Biological Technology Co., Ltd.
Tel
+86-18665676617
Fax
18665676617
Country
China
ProdList
957
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58

57961-90-7, CenthaquineRelated Search:

1-(2-PYRIDIN-2-YL-ETHYL)-PIPERAZINE N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE Centhaquine

  • PMZ-2010
  • Centhaquine
  • 2-[2-[4-(3-Methylphenyl)-1-piperazinyl]ethyl]quinoline
  • Centhaquin
  • Centhaquin PMZ-2010
  • Quinoline, 2-[2-[4-(3-methylphenyl)-1-piperazinyl]ethyl]-
  • Centhaquin >=98% (HPLC)
  • Centhaquin (Centhaquine,PMZ-2010)
  • Centhaquine (Centhaquin
  • PMZ2010,inhibit,systemic vascular resistance,Inhibitor,Centhaquin,haemorrhagic shock,PMZ 2010
  • 2-(2-(4-(m-tolyl)piperazin-1-yl)ethyl)quinoline
  • TAK438 Impurity 162
  • Centhaquin, 10 mM in DMSO
  • 57961-90-7