ChemicalBook > CAS DataBase List > Centhaquine

Centhaquine

Product Name: Centhaquine
CAS No.: 57961-90-7
Chemical Name: Centhaquine
Synonyms: PMZ-2010;Centhaquin;Centhaquine;Centhaquin PMZ-2010;TAK438 Impurity 162;Centhaquin >=98% (HPLC);Centhaquine (Centhaquin;Centhaquin, 10 mM in DMSO;Centhaquin (Centhaquine,PMZ-2010);2-(2-(4-(m-tolyl)piperazin-1-yl)ethyl)quinoline
CBNumber: CB41178241
Molecular Formula: C22H25N3
Formula Weight: 331.45
MOL File: 57961-90-7.mol

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Centhaquine Property

storage temp.: Store at -20°C
solubility: DMSO: 62.5 mg/mL (188.57 mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1786
Product name: Centhaquin
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $94.52
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1786
Product name: Centhaquin
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $405
Updated: 2025/07/31

TRC

Product number: C256615
Product name: Centhaquin
Packaging: 100mg
Price: $1540
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001987
Product name: CENTHAQUINE
Purity: 95.00%
Packaging: 5MG
Price: $498.01
Updated: 2021/12/16

DC Chemicals

Product number: 012241
Product name: Centhaquin(Centhaquine,PMZ-2010)
Packaging: 003
Price: $1800
Updated: 2021/12/16

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Centhaquine Chemical Properties,Usage,Production

Uses

Centhaquin is a centrally acting hypotensive drug similar to Clonidine (C587120), which is an α2 adrenergic agonist.

Biological Activity

Centhaquin is a centrally acting hypotensive agent. Centhaquin is an effective resuscitative agent th at improves cardiac output, reduces blood lactate levels, and improves survival time of hemorrhaged rats. Centhaquin exhibits antinociception in the mouse mediated through the opioid, the α2A and α2B adrenoceptors.

in vivo

Centhaquine (Centhaquin) (intravenous injection, 0.01-1.0 mg/kg; intraduodenal administration 1.0-2.5 mg/kg) lowers the blood pressure and reduced the heart rate of anaesthetized and unanaesthetized (decerebrate) cat in a dose-dependent manner^[1]. Centhaquine (Centhaquin) (intravertebral arterial injection; 5-10 μg) or by topical application to the exposed ventral surface of medulla or floor of the fourth ventricle causes hypotension and bradycardia as well as reduced the excitability of the vasomotor loci^[1]. Centhaquine (Centhaquin;PMZ-2010) (intravenous administration; 0.015mg/kg) can attenuate the deleterious effects of catecholamines, improving both the macro- and microcirculation during CPR^[2].

Animal Model:	Landrace/Large White piglets^[2]
Dosage:	0.015mg/kg
Administration:	Intravenous administration; Adrenaline 0.02mg/kg plus Centhaquin 0.015mg/kg
Result:	Added to adrenaline improved ROSC rates in a swine model of VF cardiac arrest.

Centhaquine Preparation Products And Raw materials

Raw materials

Preparation Products

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57961-90-7, CenthaquineRelated Search:

1-(2-PYRIDIN-2-YL-ETHYL)-PIPERAZINE N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE Centhaquine

PMZ-2010

Centhaquine

2-[2-[4-(3-Methylphenyl)-1-piperazinyl]ethyl]quinoline

Centhaquin

Centhaquin PMZ-2010

Quinoline, 2-[2-[4-(3-methylphenyl)-1-piperazinyl]ethyl]-

Centhaquin >=98% (HPLC)

Centhaquin (Centhaquine,PMZ-2010)

Centhaquine (Centhaquin

PMZ2010,inhibit,systemic vascular resistance,Inhibitor,Centhaquin,haemorrhagic shock,PMZ 2010

2-(2-(4-(m-tolyl)piperazin-1-yl)ethyl)quinoline

TAK438 Impurity 162

Centhaquin, 10 mM in DMSO

57961-90-7