ChemicalBook > CAS DataBase List > Temozolomideacid

Temozolomideacid

Product Name
Temozolomideacid
CAS No.
113942-30-6
Chemical Name
Temozolomideacid
Synonyms
TMZA;104425;Temozolomideacid;teMozoloMide acid 97%;Temozolomide Impurity C;Temozolomide Impurity 1;TEMOZOLOMIDE ACID; TMZA;Temozolamide Impurity A;Temozolomide EP Impurity B;Temozolamide acid Impurity-B
CBNumber
CB41180228
Molecular Formula
C6H5N5O3
Formula Weight
195.14
MOL File
113942-30-6.mol
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Temozolomideacid Property

Melting point:
166-168°C
Boiling point:
487.7±37.0 °C(Predicted)
Density 
1.97±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
2.88±0.20(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Safety

HS Code 
2933.99.9000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H340May cause genetic defects

H350May cause cancer

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3686
Product name
Temozolomide Acid
Packaging
50MG
Price
$68
Updated
2025/07/31
TCI Chemical
Product number
T3686
Product name
Temozolomide Acid
Packaging
250MG
Price
$235
Updated
2025/07/31
TRC
Product number
T017780
Product name
Temozolomide Acid
Packaging
100mg
Price
$120
Updated
2021/12/16
Usbiological
Product number
021337
Product name
Temozolomide Acid
Packaging
10mg
Price
$446
Updated
2021/12/16
AK Scientific
Product number
SYN5662
Product name
Temozolomide Acid
Packaging
100mg
Price
$1296
Updated
2021/12/16
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Temozolomideacid Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Temozolomide (T017775) as antitumor agent.

Synthesis

85622-93-1

113942-30-6

General procedure: Example 1 Preparation of 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid (EP0252682) 1. 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide (2.577 mmol, 0.5 g) was mixed with concentrated sulfuric acid (4 mL) under stirring conditions. 2. a solution was prepared by dissolving sodium nitrite (9.4 mmol, 0.65 g) in 2.6 mL of water. 3. Slowly add the aqueous sodium nitrite solution dropwise to the above mixture under cooling in an ice bath (keeping the temperature below 15°C). 4. After the dropwise addition, the reaction mixture was stirred at room temperature overnight. 5. 10 g of ice was added to the reaction mixture and cooling was continued in an ice bath for 1 hour. 6. The solid product was collected by filtration. 7. The collected solid product was dried under vacuum to give 0.493 g of 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid. The yield was 98.6%.

References

[1] European Journal of Medicinal Chemistry, 2002, vol. 37, # 4, p. 323 - 332
[2] Patent: EP1798234, 2007, A1. Location in patent: Page/Page column 11
[3] Patent: US2018/79754, 2018, A1. Location in patent: Paragraph 0082; 0101-0102
[4] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 691 - 702
[5] Journal of Medicinal Chemistry, 2002, vol. 45, # 25, p. 5458 - 5470

Temozolomideacid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Temozolomideacid manufacturers

Career Henan Chemical Co
Product
Temozolomideacid 113942-30-6
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

113942-30-6, TemozolomideacidRelated Search:

TeMozoloMide Metabolite - MTIC 3-Amino-2-(formylamino)-3-iminopropanamide Temozolomide 5-Amino-4-imidazolecarboxamide Cyano temozolomide 4-diazo-4H-imidazole-5-carboxamide Ulipristal acetate InterMediate 1,5-dihydro-4H-imidazo[4,5-d]-1,2,3-triazin-4-one 1H-Imidazole-4-carboxamide,5-(methylamino)-(9CI) Cyanotemozolomide 5-(Amino-1-(N-methyl Carbamoyl) 4-diazoimidazole-5-carboxamide

  • 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxylic acid
  • Temozolomide-8-carboxylic acid
  • 3,4-Dihydro-3-Methyl-4-oxo-iMidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic Acid
  • teMozoloMide acid 97%
  • 3-Methyl-4-oxo-3,4-dihydroiMidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid
  • Temozolomideacid
  • Temozolomide Impurity 1
  • Temozolomide Impurity C
  • Temozolomide Impurity 2(EP-B)
  • 104425
  • Temozolomide EP Impurity B (Temozolomide Acid)
  • Temozolomide EP Impurity B
  • TEMOZOLOMIDE ACID; TMZA
  • TMZA
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  • Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3-methyl-4-oxo-
  • Temozolomide Impurity 2（Temozolomide EP Impurity B）
  • Temozolomide AcidQ: What is Temozolomide Acid Q: What is the CAS Number of Temozolomide Acid Q: What is the storage condition of Temozolomide Acid Q: What are the applications of Temozolomide Acid
  • Temozolamide acid Impurity-B
  • 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic Acid (Temozolomide Acid)
  • Temozolomide Acid, 10 mM in DMSO
  • 113942-30-6
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