Epothilone D

ChemicalBook > CAS DataBase List > Epothilone D

Product Name: Epothilone D
CAS No.: 189453-10-9
Chemical Name: Epothilone D
Synonyms: Epo D;CS-1161;KOS 862;Ebomycin;NSC 703147;Epothilone D;12,13-Deoxyepo;Desoxyepothilone B;13-Desoxyepothilone B;Epothilone D (KOS-862)
CBNumber: CB41214330
Molecular Formula: C27H41NO5S
Formula Weight: 491.68
MOL File: 189453-10-9.mol

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Epothilone D Property

Melting point:: 63-66°C
alpha: D22 -61.3° (c = 2.5 in methanol)
Boiling point:: 663.7±55.0 °C(Predicted)
Density: 1.084±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Soluble in DMSO
form: solid
pka: 13.47±0.70(Predicted)
color: white to off-white
InChIKey: XOZIUKBZLSUILX-GIQCAXHBSA-N
SMILES: O1[C@H](/C(/C)=C/C2=CSC(C)=N2)CC=C(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC1=O |t:13|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18765
Product name: Epothilone D
Purity: ≥99%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 18765
Product name: Epothilone D
Purity: ≥99%
Packaging: 5mg
Price: $179
Updated: 2024/03/01

Cayman Chemical

Product number: 18765
Product name: Epothilone D
Purity: ≥99%
Packaging: 10mg
Price: $317
Updated: 2024/03/01

Cayman Chemical

Product number: 18765
Product name: Epothilone D
Purity: ≥99%
Packaging: 25mg
Price: $692
Updated: 2024/03/01

Usbiological

Product number: E3428-75C
Product name: Epothilone D
Packaging: 100ug
Price: $496
Updated: 2021/12/16

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Epothilone D Chemical Properties,Usage,Production

Description

Epothilones are microtubule-stabilizing agents with potential anti-neoplastic actions. They are natural macrolides that have high potency in both taxane-sensitive and taxane-resistant models. Epothilone D is a desoxy form of epothilone B (Item No. 10924) that inhibits the growth of a variety of cancer cells both in vitro (IC₅₀ values range from 0.97 to 21 nM) and in mice. Epothilone D is brain penetrant and reduces neurodegeneration in aged tau transgenic mice. Effects include improved axonal transport, decreased tau neuropathology, and reduced hippocampal neuron loss. Epothilone D also rescues microtubule defects and attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease.

Chemical Properties

White Foam

Uses

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells'' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.

Definition

ChEBI: An epithilone that is epithilone C in which the hydrogen at position 13 of the oxacyclohexadec-13-ene-2,6-dione macrocycle has been replaced by a methyl group.

in vitro

epothilone d is a more potent microtubule stabilizer in vitro than epothilone a or b. in vitro, epothilone d showed potent cytotoxicity in a panel of human tumor cell lines, with similar potency to paclitaxel. it also showed definite advantage over paclitaxel in drug-resistant cell lines, and retained its cytotoxicity against a multidrug resistant cell line over-expressing p-glycoprotein [1].

in vivo

in vivo, antitumor efficacy of epothilone d has been observed in both paclitaxel sensitive and resistant xenografts, as well as certain multidrug resistant xenografts including a doxorubinresistant ccrf-cem leukemic cell xenograft [1].

target

Tubulin

IC 50

2.9 nm for mcf-7 cell line; 2.7 nm for kb-31 cell line; 9.5 nm for ccrf-cem cell line

References

[1] konner j, grisham rn, park j, o'connor oa, cropp g, johnson r, hannah al, hensley ml, sabbatini p, mironov s, danishefsky s, hyman d, spriggs dr, dupont j, aghajanian c. phase i clinical, pharmacokinetic, and pharmacodynamic study of kos-862 (epothilone d) in patients with advanced solid tumors and lymphoma. invest new drugs. 2012 dec;30(6):2294-302. doi: 10.1007/s10637-011-9765-7.

Epothilone D Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Epothilone D manufacturers

Dideu Industries Group Limited

Product: Epothilone D 189453-10-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-02

Shaanxi Dideu Medichem Co. Ltd

Product: Epothilone D 189453-10-9
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

Shaanxi Dideu Medichem Co. Ltd

Product: Epothilone D 189453-10-9
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

189453-10-9, Epothilone DRelated Search:

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Paclitaxel Tigecycline MITHRAMYCIN A Abiraterone Daptomycin Geldanamycin RIFAMYCIN SV Vinorelbine tartrate Epothilone B Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9-tetramethyl-16-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (4S,7R,8S,9S,13Z,16S)- Epothilone A epothilone E BOC-3-ENDO-AMINOBICYCLO[2.2.1]HEPTANE-2-ENDO-CARBOXYLIC ACID (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester 2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel 4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID 6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE

Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (4S,7R,8S,9S,13Z,16S)-

Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl -16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (4S-(4R*,7S,8R*,9R*,1 3Z,16R*(E)))-

(3S,7S,14S,15S,16R)-3,15-Dihydroxy-2,2,10,14,16-pentamethyl-7-[1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-6-oxacyclohexadec-9-ene-1,5-dione

Epothilone D

Desoxyepothilone B

12;13-DESOXYEPOTHILONE B; DESOXYEPOTHILONE B; KOS 862

13-Desoxyepothilone B

CS-1161

Epothilone D (KOS-862)

12,13-Deoxyepo

(4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentaMethyl-16-[(1E)-1-Methyl-2-(2-Methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione

12,13-Desoxyepothilone B

Epo D

KOS 862

NSC 703147

Paclitaxel Impurity 110

Epothilone D USP/EP/BP

Ebomycin

189453-10-9

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