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RIFAMYCIN SV

Product Name
RIFAMYCIN SV
CAS No.
6998-60-3
Chemical Name
RIFAMYCIN SV
Synonyms
rifocyn;rifocin;rifamicinesv;RIFAMYCIN SV;RIFAMYCIN INN;Rifamycin S-Na;Rifamycin (9CI);RIFAMYCIN SV USP/EP/BP;Rifaximin EP Impurity C;Rifaximin impurity C (EP)
CBNumber
CB2731058
Molecular Formula
C37H47NO12
Formula Weight
697.77
MOL File
6998-60-3.mol
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RIFAMYCIN SV Property

Melting point:
300° (dec 140°)
alpha 
D20 -4° (methanol)
Boiling point:
701.9°C (rough estimate)
Density 
1.2275 (rough estimate)
refractive index 
1.5350 (estimate)
pka
5.17±0.70(Predicted)
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Safety

Toxicity
LD50 in mice (mg/kg): 550 i.v.; 625 i.p.; 2120 orally (Bergamini, Fowst)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
R509625
Product name
Rifogal
Packaging
50mg
Price
$95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013235
Product name
RIFAMYCIN SV
Purity
95.00%
Packaging
5MG
Price
$497.32
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013235
Product name
RIFAMYCIN SV
Purity
95.00%
Packaging
100MG
Price
$4960
Updated
2021/12/16
AvaChem
Product number
2841A
Product name
Rifamycin SV
Packaging
10g
Price
$189
Updated
2021/12/16
AvaChem
Product number
2841A
Product name
Rifamycin SV
Packaging
100mg
Price
$40
Updated
2021/12/16
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RIFAMYCIN SV Chemical Properties,Usage,Production

Uses

Rifogal (Rifaximin EP Impurity C NA) is a antibacterial drug which functions by inhibiting bacterial RNA polymerase (RNAP), is an important part of the antibacteral armamentarium. Also, it is one of the few drugs in a multidrug regimens for treating lung disease (LD) due to Mycobacterium avium complex (MAC).

Definition

ChEBI: A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.

Pharmaceutical Applications

The simplest rifamycin in clinical use, obtained by elimination of a glycolic moiety from rifamycin B. Formulated as sodium salt for parenteral administration. Also available for topical use. Its activity, general properties and pharmacokinetics are very similar to those of rifamide. It is orally absorbed and excreted mainly in the bile. Intramuscular doses of 250 mg produce mean plasma levels of about 2 mg/L. The plasma half-life is around 2 h.
In addition to uses similar to those of rifamide, it is administered topically in surgery and has been proposed for the treatment of synovitis by intra-articular injections. A topical preparation is used for application to wounds and bedsores. Cases of anaphylactic reactions have been reported after local administration of the drug.

in vivo

Rifamycin (5 mg/day; s.c.; 3 days a week) is effective in mice infected with M. tuberculosis, significantly reducing the number of viable bacteria in the body[4].
Rifamycin (12.5-25 mg/kg; peritoneal lavage) can improve the survival rate of rats with experimental intraperitoneal infection and significantly reduce the number of intraperitoneal bacteria and adhesion formation[6].
Rifamycin (5-40 mg/kg; esophageal gavage; once a day, 5 days a week; 4 weeks) shortens oral treatment duration in a mouse model of Mycobacterium ulcerans disease[8].
Rifamycin (0.1 mL; intraaural administration; twice daily; 10 days) does not cause hearing loss in adult or weanling rats[9].
Rifamycin (1 mg i.v. bolus followed by 4 mg i.v. infusion; 70 min) interferes with three major steps of Bile acid metabolism in rats with intravenous Sodium cholate (HY-N0324A) infusion, resulting in a significant decrease in bile acid uptake and excretion[10].
Rifamycin (10-160 mg/kg; s.c.; single dose) is approximately 11 times less effective than Metronidazole (HY-B0318) in a mouse Bacteroides fragilis thigh infection model[11].

Animal Model:Male Wistar rats (weight 200-250 g), cecal ligation puncture (CLP)-induced intra-abdominal infection model[6]
Dosage:25 mg/kg, 12.5 mg/kg
Administration:Peritoneal lavage
Result:Improved survival from 50% in the control group to 91.7% in the 25 mg/kg group and 100% in the 12.5 mg/kg group.
Significantly reduced adhesion formation.
Showed a greater reduction in bacterial counts in peritoneal fluid (25 mg/kg).

Purification Methods

Rifamycin SV gives yellow-orange crystals from Et2O/pet ether or aqueous EtOH, is very soluble in MeOH, EtOH, Me2CO and EtOAc, and is less soluble in Et2O and HCO3-, but slightly soluble in H2O and pet ether. Its UV has max at 223, 314 and 445nm ( 1cm 586, 322 and 204) in phosphatebuffer pH 7. [NMR: Bergamini & Fowst Arzneim.-Forsch 15 951 1965.]

RIFAMYCIN SV Preparation Products And Raw materials

Raw materials

Preparation Products

Rifamycin Sodium
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RIFAMYCIN SV Suppliers

China 75 India 5 United Kingdom 2 United States 10 Global 92
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
Advantage
52
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
3B Scientific (Wuhan) Corporation Limited
Tel
027-88063677 18971314022;
Fax
027-88063656
Email
sales@3bsc.com
Country
China
ProdList
294
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1987
Advantage
55
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View Lastest Price from RIFAMYCIN SV manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
RIFAMYCIN 6998-60-3
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-18
Career Henan Chemical Co
Product
rifamycin SV 6998-60-3
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-02-04

6998-60-3, RIFAMYCIN SVRelated Search:

Rifamycin O RIFAMYCIN Rifamycin Sodium 3-FORMYL RIFAMYCIN SV,3- FORMYL RIFAMYCIN SV(RIFAMPICIN INTERMEDIATE ) 3-(4-Methylpiperazinyliminomethyl)rifamycin SV, Rifampin, Rifamycin AMP,3-(4-METHYLPIPERAZINYLIMINOMETHYL)RIFAMYCIN SV Rifapentine Rifalazil Rifaximin Rifabutin Riboflavin 3-Piperazinoiminomethyl Rifamycin SV 3-AMINO-4-IMINORIFAMYCIN-S 3-[2-(2-Methoxyethoxy)ethoxyiminomethyl]rifamycin SV 3-((dimethylhydrazono)methyl)rifamycin SV RIFAMYCIN SV-3 FORMYL 3-(Diethylaminomethyl)rifamycin SV 3-formyl-23-(O-(beta-glucopyranosyl))rifamycin SV 3-(Cyclohexyloxyiminomethyl)rifamycin SV

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  • C37H47NO12