Rifamycin Sodium

Product Name: Rifamycin Sodium
CAS No.: 14897-39-3
Chemical Name: Rifamycin Sodium
Synonyms: Rifamycin SV s;RIFAMYCIN SODIUM;Rifamycinsodiumsal;RIFAMYCIN SV-SODIUM;RIFAMPICIN SV SODIUM;Rifamycin sodium CRS;rifamycin sodium salt;Rifamycin Na USP/EP/BP;Rifamycin SV Monosodium;RIFAMYCIN,MONOSODIUMSALT
CBNumber: CB6854850
Molecular Formula: C37H48NNaO12
Formula Weight: 721.78
MOL File: 14897-39-3.mol

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Rifamycin Sodium Property

Melting point:: >215°C (dec.)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: ethanol: soluble50mg/mL
form: powder
color: Dark Red
Water Solubility: Soluble in water, alcohol and dimethyl sulfoxide.
Merck: 13,8302
InChIKey: DJAAUWJRMPPGDA-HSBICLRHNA-N

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: KD1922500
F: 8-10-23

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R8626
Product name: Rifamycin SV sodium salt
Purity: potency: ≥900units (dry basis)
Packaging: 1g
Price: $122
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR1664
Product name: Rifamycin sodium
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $139.65
Updated: 2025/07/31

Cayman Chemical

Product number: 21441
Product name: Rifamycin SV (sodium salt)
Purity: ≥98%
Packaging: 500mg
Price: $30
Updated: 2021/12/16

Cayman Chemical

Product number: 21441
Product name: Rifamycin SV (sodium salt)
Purity: ≥98%
Packaging: 1g
Price: $54
Updated: 2021/12/16

Sigma-Aldrich

Product number: R8626
Product name: Rifamycin SV sodium salt
Purity: potency: ≥900units (dry basis)
Packaging: 5g
Price: $424
Updated: 2025/07/31

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Rifamycin Sodium Chemical Properties,Usage,Production

Chemical Properties

Dark Red Solid

Uses

Rifamycin SV Sodium (Rifaximin EP Impurity C) is a semi-synthetic antibiotic derived from Rifamycin S. (1) Antibacterial (2). Potency >900 units (dry basis).

Uses

Semi-synthetic antibiotic derived from Rifamycin S. Antibacterial. Potency >900 units (dry basis).

Biological Activity

Rifamycin SV inhibits selective (E. coli, B. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunit, a mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.

in vivo

Rifamycin (5 mg/day; s.c.; 3 days a week) sodium is effective in mice infected with M. tuberculosis, significantly reducing the number of viable bacteria in the body^[4].
Rifamycin (12.5-25 mg/kg; peritoneal lavage) sodium can improve the survival rate of rats with experimental intraperitoneal infection and significantly reduce the number of intraperitoneal bacteria and adhesion formation^[6].
Rifamycin (5-40 mg/kg; esophageal gavage; once a day, 5 days a week; 4 weeks) sodium shortens oral treatment duration in a mouse model of Mycobacterium ulcerans disease^[8].
Rifamycin (0.1 mL; intraaural administration; twice daily; 10 days) sodium does not cause hearing loss in adult or weanling rats^[9].
Rifamycin (1 mg i.v. bolus followed by 4 mg i.v. infusion; 70 min) sodium interferes with three major steps of Bile acid metabolism in rats with intravenous Sodium cholate (HY-N0324A) infusion, resulting in a significant decrease in bile acid uptake and excretion^[10].
Rifamycin (10-160 mg/kg; s.c.; single dose) sodium is approximately 11 times less effective than Metronidazole (HY-B0318) in a mouse Bacteroides fragilis thigh infection model^[11].

Animal Model:	Male Wistar rats (weight 200-250 g), cecal ligation puncture (CLP)-induced intra-abdominal infection model^[6]
Dosage:	25 mg/kg, 12.5 mg/kg
Administration:	Peritoneal lavage
Result:	Improved survival from 50% in the control group to 91.7% in the 25 mg/kg group and 100% in the 12.5 mg/kg group. Significantly reduced adhesion formation. Showed a greater reduction in bacterial counts in peritoneal fluid (25 mg/kg).

Rifamycin Sodium Preparation Products And Raw materials

Raw materials

RIFAMYCIN SV

Preparation Products

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Rifamycin Sodium Suppliers

Canada 1 China 230 Europe 2 Germany 3 India 3 Italy 2 Japan 1 South Korea 2 Switzerland 1 United Kingdom 4 United States 23 Global 272

Jiangxi ravel Biotechnology Co.,Ltd

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ZHENGZHOU MINZHONG PHARMACEUTICAL CO.,LTD.

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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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Energy Chemical

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Shandong Xiya Chemical Co., Ltd

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China Langchem Inc.

Tel: 0086-21-58956006
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Tianjin heowns Biochemical Technology Co., Ltd.

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Sinopharm Chemical Reagent Co,Ltd.

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View Lastest Price from Rifamycin Sodium manufacturers

RongNa Biotechnology Co.,Ltd

Product: Rifamycin sodium salt 14897-39-3
Price: US $1.00/g
Min. Order: 1g
Purity: 0.99
Supply Ability: 20 tons
Release date: 2025-06-02

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Rifamycin Sodium 14897-39-3
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kg
Release date: 2021-10-20

Hebei Chuanghai Biotechnology Co., Ltd

Product: Rifamycin Sodium 14897-39-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-05

14897-39-3, Rifamycin SodiumRelated Search:

Diclofenac sodium RIFAMYCIN SV Sodium sulfate Rifamycin O Sodium acetate Disodium phosphonomycin Sodium bicarbonate Sodium benzoate Sodium hydroxide Sodium chloride Sodium chlorite Rifampicin RIFAMYCIN RHENIUM(III) CHLORIDE RHENIUM(VII) OXIDE Riboflavin 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 1,3-DIHYDROXYNAPHTHALENE

RIFAMYCIN SODIUM

RifaMycin, sodiuM salt (1:1)

Rifamycin SV s

Rifamycin SV sodium, >=900 IU/mg

RIFAMPICIN SV SODIUM

RIFAMYCIN SV-SODIUM

RIFAMYCIN SV SODIUM SALT

RIFAMYCIN SV SODIUM SALT HEXAHYDRATE

rifamycin sodium salt

Rifamycin SV Monosodium

RIFAMYCIN,MONOSODIUMSALT

Rifamycin SV hexahydrate sodium salt

2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, monosodium salt

RifaMycin SV MonosodiuM salt

5,6,9,17,19,21-Hexahydroxy-23-Methoxy-2,4,12,16,18,20,22-heptaMethyl-

Rifamycin sodium CRS

Rifamycin SV Sodium Salt (Rifaximin EP Impurity C Sodium Salt)

(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione sodium salt

Rifamycinsodiumsal

Rifamycin Na USP/EP/BP

Rifamycin Sodium USP/EP/BP

TIANFU-CHEM CAS:14897-39-3 Rifamycin sodium salt

Rifaximin EP Impurity C as Sodium Salt

Rifaximin Impurity C as Sodium Salt

Rifamycin Sodium (Rifamycin SV Sodium)

Rifamycin sodium, 10 mM in DMSO

Rifamycin SV sodium - Bio-X ?

14897-39-3

14897-39-7

C37H47NNaO12

C37H46NNaO126H2O

C37H46NO12Na

C37H46NNaO12

C37H46NaNO12

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14897-39-3