ChemicalBook > CAS DataBase List > RIFAMYCIN SV

RIFAMYCIN SV

Product Name: RIFAMYCIN SV
CAS No.: 6998-60-3
Chemical Name: RIFAMYCIN SV
Synonyms: rifocyn;rifocin;rifamicinesv;RIFAMYCIN SV;RIFAMYCIN INN;Rifamycin S-Na;Rifamycin (9CI);RIFAMYCIN SV USP/EP/BP;Rifaximin EP Impurity C;Rifaximin impurity C (EP)
CBNumber: CB2731058
Molecular Formula: C37H47NO12
Formula Weight: 697.77
MOL File: 6998-60-3.mol

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RIFAMYCIN SV Property

Melting point:: 300° (dec 140°)
alpha: D20 -4° (methanol)
Boiling point:: 701.9°C (rough estimate)
Density: 1.2275 (rough estimate)
refractive index: 1.5350 (estimate)
pka: 5.17±0.70(Predicted)

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Safety

Toxicity: LD50 in mice (mg/kg): 550 i.v.; 625 i.p.; 2120 orally (Bergamini, Fowst)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: R509625
Product name: Rifogal
Packaging: 50mg
Price: $95
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013235
Product name: RIFAMYCIN SV
Purity: 95.00%
Packaging: 5MG
Price: $497.32
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013235
Product name: RIFAMYCIN SV
Purity: 95.00%
Packaging: 100MG
Price: $4960
Updated: 2021/12/16

AvaChem

Product number: 2841A
Product name: Rifamycin SV
Packaging: 100mg
Price: $40
Updated: 2021/12/16

AvaChem

Product number: 2841A
Product name: Rifamycin SV
Packaging: 1g
Price: $59
Updated: 2021/12/16

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RIFAMYCIN SV Chemical Properties,Usage,Production

Uses

Rifogal (Rifaximin EP Impurity C NA) is a antibacterial drug which functions by inhibiting bacterial RNA polymerase (RNAP), is an important part of the antibacteral armamentarium. Also, it is one of the few drugs in a multidrug regimens for treating lung disease (LD) due to Mycobacterium avium complex (MAC).

Definition

ChEBI: A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.

Pharmaceutical Applications

The simplest rifamycin in clinical use, obtained by elimination of a glycolic moiety from rifamycin B. Formulated as sodium salt for parenteral administration. Also available for topical use. Its activity, general properties and pharmacokinetics are very similar to those of rifamide. It is orally absorbed and excreted mainly in the bile. Intramuscular doses of 250 mg produce mean plasma levels of about 2 mg/L. The plasma half-life is around 2 h.
In addition to uses similar to those of rifamide, it is administered topically in surgery and has been proposed for the treatment of synovitis by intra-articular injections. A topical preparation is used for application to wounds and bedsores. Cases of anaphylactic reactions have been reported after local administration of the drug.

in vivo

Rifamycin (5 mg/day; s.c.; 3 days a week) is effective in mice infected with M. tuberculosis, significantly reducing the number of viable bacteria in the body^[4].
Rifamycin (12.5-25 mg/kg; peritoneal lavage) can improve the survival rate of rats with experimental intraperitoneal infection and significantly reduce the number of intraperitoneal bacteria and adhesion formation^[6].
Rifamycin (5-40 mg/kg; esophageal gavage; once a day, 5 days a week; 4 weeks) shortens oral treatment duration in a mouse model of Mycobacterium ulcerans disease^[8].
Rifamycin (0.1 mL; intraaural administration; twice daily; 10 days) does not cause hearing loss in adult or weanling rats^[9].
Rifamycin (1 mg i.v. bolus followed by 4 mg i.v. infusion; 70 min) interferes with three major steps of Bile acid metabolism in rats with intravenous Sodium cholate (HY-N0324A) infusion, resulting in a significant decrease in bile acid uptake and excretion^[10].
Rifamycin (10-160 mg/kg; s.c.; single dose) is approximately 11 times less effective than Metronidazole (HY-B0318) in a mouse Bacteroides fragilis thigh infection model^[11].

Animal Model:	Male Wistar rats (weight 200-250 g), cecal ligation puncture (CLP)-induced intra-abdominal infection model^[6]
Dosage:	25 mg/kg, 12.5 mg/kg
Administration:	Peritoneal lavage
Result:	Improved survival from 50% in the control group to 91.7% in the 25 mg/kg group and 100% in the 12.5 mg/kg group. Significantly reduced adhesion formation. Showed a greater reduction in bacterial counts in peritoneal fluid (25 mg/kg).

Purification Methods

Rifamycin SV gives yellow-orange crystals from Et2O/pet ether or aqueous EtOH, is very soluble in MeOH, EtOH, Me2CO and EtOAc, and is less soluble in Et2O and HCO3-, but slightly soluble in H2O and pet ether. Its UV has max at 223, 314 and 445nm ( 1cm 586, 322 and 204) in phosphatebuffer pH 7. [NMR: Bergamini & Fowst Arzneim.-Forsch 15 951 1965.]

RIFAMYCIN SV Preparation Products And Raw materials

Raw materials

Preparation Products

Rifamycin Sodium

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RIFAMYCIN SV Suppliers

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View Lastest Price from RIFAMYCIN SV manufacturers

Hebei Zhanyao Biotechnology Co. Ltd

Product: RIFAMYCIN 6998-60-3
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-18

Career Henan Chemical Co

Product: rifamycin SV 6998-60-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-02-04

6998-60-3, RIFAMYCIN SVRelated Search:

Rifamycin O RIFAMYCIN Rifamycin Sodium 3-FORMYL RIFAMYCIN SV,3- FORMYL RIFAMYCIN SV(RIFAMPICIN INTERMEDIATE ) 3-(4-Methylpiperazinyliminomethyl)rifamycin SV, Rifampin, Rifamycin AMP,3-(4-METHYLPIPERAZINYLIMINOMETHYL)RIFAMYCIN SV Rifapentine Rifalazil Rifaximin Rifabutin Riboflavin 3-Piperazinoiminomethyl Rifamycin SV 3-AMINO-4-IMINORIFAMYCIN-S 3-[2-(2-Methoxyethoxy)ethoxyiminomethyl]rifamycin SV 3-((dimethylhydrazono)methyl)rifamycin SV RIFAMYCIN SV-3 FORMYL 3-(Diethylaminomethyl)rifamycin SV 3-formyl-23-(O-(beta-glucopyranosyl))rifamycin SV 3-(Cyclohexyloxyiminomethyl)rifamycin SV

RIFAMYCIN SV

17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-21-acetate

rifamicinesv

rifocin

rifocyn

Rifamycin S-Na

Rifaximin EP Impurity C

19,21,25(29),26-octaen-13-yl acetate

Rifaximin impurity C (EP)

Rifaximin Impurity 3 (Rifaximin EP Impurity C)

Rifampicin Impurit Ⅱ:rifamycin SV

Rifaximin EP Impurity C (Rifamycin SV)

Rifamycin (9CI)

RIFAMYCIN SV USP/EP/BP

(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione

RifamycinQ: What is Rifamycin Q: What is the CAS Number of Rifamycin Q: What is the storage condition of Rifamycin Q: What are the applications of Rifamycin

RIFAMYCIN INN

Rifaximin EP Impurity C (Rifamycin)

Rifampicin Impurit Ⅱ:rifamycin SV

First International Standard for Rifamycin SV

6998-60-3

C37H47NO12