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Rifalazil

Product Name
Rifalazil
CAS No.
129791-92-0
Chemical Name
Rifalazil
Synonyms
KRM 1648;RIFALAZIL;Rifalazil USP/EP/BP;3'-Hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin;1-Deoxy-1'-dehydro-1-oxo-3'-hydroxy-5'-[4-(2-methylpropyl)piperazino]rifamycin VIII;5,12-Dihydroxy-2,4-dimethyl-10-[4-(2-methyl-propyl)-l-piperazinyl]-2,7-[oxy(5-acetoxy-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxo-l,ll,13-pentadecatriene-l,15-diyl)imino]-6H-benzofuro[4,5-a]phenoxazine-l(2H),6-dione
CBNumber
CB2437664
Molecular Formula
C51H64N4O13
Formula Weight
941.07
MOL File
129791-92-0.mol
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Rifalazil Property

Melting point:
195-200° (dec)
Boiling point:
1065.6±65.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
4°C, away from moisture
solubility 
DMSO: 8.33 mg/mL (8.85 mM)
pka
4.28±0.70(Predicted)
form 
Solid
color 
Blue to dark blue
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
R504000
Product name
Rifalazil
Packaging
50mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0024983
Product name
Rifalazil
Purity
98.44%
Packaging
50mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0024983
Product name
Rifalazil
Purity
98.44%
Packaging
100mg
Price
$1320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009212
Product name
RIFALAZIL
Purity
95.00%
Packaging
1G
Price
$1637.21
Updated
2021/12/16
ChemScene
Product number
CS-0024983
Product name
Rifalazil
Purity
98.44%
Packaging
250mg
Price
$2550
Updated
2021/12/16
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Rifalazil Chemical Properties,Usage,Production

Uses

Antibacterial (antimycobacterial).

Uses

Rifalazil has been used as a part of multi drug regimen in the treatment of tuberculosis.

Definition

ChEBI: Rifalazil is a phenoxazine.

in vivo

Rifalazil (oral gavage; 20, 25, and 150 mg/kg; 6-8 weeks) combines with isoniazid (INH) for 6 weeks or greater significantly reduced the number of mice per group in which M. tuberculosis is detected in both spleens and lungs compared to the reductions for the early and late controls. And the addition of Pyrazinamide (PZA) does not significantly improve RLZ-INH therapy at any time point[2].

Animal Model:Female CD-1 mice infected with 5.2 × 107?viable mycobacteria[2]
Dosage:20, 25, and 150 mg/kg; 6-8 weeks
Administration:Oral gavage
Result:Combined with isoniazid (INH) showed its potential for short-course treatment of?Mycobacterium tuberculosis?infection.

Rifalazil Preparation Products And Raw materials

Raw materials

Preparation Products

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Rifalazil Suppliers

China 19 Germany 1 India 1 United Kingdom 2 United States 10 Global 33
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32159
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7859
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30230
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 18108052721
Email
2850505130@qq.com
Country
China
ProdList
5173
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49732
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988968278
Fax
QQ：3283937693
Email
YN_research@163.com
Country
China
ProdList
2892
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24642
Advantage
58

129791-92-0, RifalazilRelated Search:

Dimethyl sulfoxide RIFAMYCIN SV Dimethyl ether Propyl butyrate CHLOROPHOSPHONAZO III N,N-Dimethylformamide Solvent Red 43 Propyl gallate Rifamycin Sodium Rifapentine ETHANE Isopropyl alcohol Dimethyl fumarate Dimethyl carbonate Nile Red PHENYLGLYOXAL MONOHYDRATE 2-Amino-4'-methoxyacetophenone 1-(3-Methoxyphenyl)piperazine

  • RIFALAZIL
  • KRM 1648
  • 3'-Hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin
  • 1-Deoxy-1'-dehydro-1-oxo-3'-hydroxy-5'-[4-(2-methylpropyl)piperazino]rifamycin VIII
  • 5,12-Dihydroxy-2,4-dimethyl-10-[4-(2-methyl-propyl)-l-piperazinyl]-2,7-[oxy(5-acetoxy-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxo-l,ll,13-pentadecatriene-l,15-diyl)imino]-6H-benzofuro[4,5-a]phenoxazine-l(2H),6-dione
  • Rifalazil USP/EP/BP
  • 129791-92-0
  • C51H64N4O13