PHENYLGLYOXAL MONOHYDRATE
- Product Name
- PHENYLGLYOXAL MONOHYDRATE
- CAS No.
- 1075-06-5
- Chemical Name
- PHENYLGLYOXAL MONOHYDRATE
- Synonyms
- PHENYLGLYOXAL;PHENYLGLYOXAL HYDRATE;2,2-Dihydroxy-1-phenylethan-1-one;2,2-dihydroxy-acetophenon;Ethanone, 2,2-dihydroxy-1-phenyl-;PHENYLGLYOXAL MONOHYDRATE;Phenylglyoxal hydrate 97%;2,2-dihydroxyacetophenone;P-PHENYLGLYOXAL MONOHYDRATE;PhenylglyoxalMonohydrate>
- CBNumber
- CB3454176
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 1075-06-5.mol
PHENYLGLYOXAL MONOHYDRATE Property
- Melting point:
- 76-79 °C(lit.)
- Boiling point:
- 142 °C125 mm Hg(lit.)
- Density
- 1.1603 (rough estimate)
- refractive index
- 1.5120 (estimate)
- Flash point:
- 142°C/125mm
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 95% ethanol: soluble5%, clear to very slightly hazy, colorless to light yellow
- pka
- 10.97±0.41(Predicted)
- form
- Powder
- color
- White to light yellow or pinkish
- Water Solubility
- Partly miscible with water.
- BRN
- 1854721
- CAS DataBase Reference
- 1075-06-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 22-26-36
- WGK Germany
- 3
- RTECS
- MD3260000
- HS Code
- 2914.40.4000
- Toxicity
- mouse,LD50,oral,500mg/kg (500mg/kg),Journal of Medicinal and Pharmaceutical Chemistry. Vol. 1, Pg. 365, 1959.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 142433
- Product name
- Phenylglyoxal hydrate
- Purity
- 97%
- Packaging
- 5g
- Price
- $78.9
- Updated
- 2025/07/31
- Product number
- 142433
- Product name
- Phenylglyoxal hydrate
- Purity
- 97%
- Packaging
- 25g
- Price
- $209
- Updated
- 2025/07/31
- Product number
- P0652
- Product name
- Phenylglyoxal Monohydrate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $347
- Updated
- 2025/07/31
- Product number
- P0652
- Product name
- Phenylglyoxal Monohydrate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $1049
- Updated
- 2025/07/31
- Product number
- P327503
- Product name
- Phenylglyoxal monohydrate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
PHENYLGLYOXAL MONOHYDRATE Chemical Properties,Usage,Production
Uses
Phenylglyoxal monohydrate was used to modify pig muscle carbonic anhydraseIII and as a specific reagent for arginine groups. It was also used to prepare pyrrolinone and furan derivatives and as as a chemiluminescent reagent for the determination of purines.
Biochem/physiol Actions
Phenylglyoxal is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.
Synthesis
98-86-2
1075-06-5
GENERAL METHOD: Selenium dioxide (220 mg, 2 mmol) was dissolved in a mixed solution of 1,4-dioxane (1 mL) and deionized water (2 drops), followed by the addition of acetophenone 1a (120 mg, 1 mmol). The reaction mixture was refluxed with stirring for 7 h (the reaction progress was monitored by TLC, the unfolding agent was ethyl acetate/petroleum ether, 1:4, v/v). After completion of the reaction, it was cooled to room temperature, dichloromethane (5 mL) was added to the mixture and filtered through diatomaceous earth. The diatomaceous earth was washed with dichloromethane (3 x 5 mL). All organic phases were combined and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:10 v/v) to give benzoylformaldehyde hydrate 2a (121 mg, 80% yield). Compounds 2b~2m were synthesized following the same procedure in a range of 61%~82% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 8, p. 1660 - 1664
[2] Tetrahedron Asymmetry, 2010, vol. 21, # 18, p. 2244 - 2248
[3] Tetrahedron, 2011, vol. 67, # 41, p. 8000 - 8008
[4] Chemistry of Heterocyclic Compounds, 2018, vol. 54, # 1, p. 51 - 57
[5] Khim. Geterotsikl. Soedin., 2018, vol. 54, # 1, p. 51 - 57,7
PHENYLGLYOXAL MONOHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PHENYLGLYOXAL MONOHYDRATE manufacturers
- Product
- Phenylglyoxal Monohydrate 1075-06-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- PHENYLGLYOXAL MONOHYDRATE 1075-06-5
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-04
- Product
- PHENYLGLYOXAL MONOHYDRATE 1075-06-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 200kgs
- Release date
- 2020-01-16