4-NITROPHENYLGLYOXYLIC ACID
- Product Name
- 4-NITROPHENYLGLYOXYLIC ACID
- CAS No.
- 14922-36-2
- Chemical Name
- 4-NITROPHENYLGLYOXYLIC ACID
- Synonyms
- 2-(4-NITROPHENYL)-2-OXOACETIC ACID;SKL212;2-(4-Nitrophenyl);p-Nitrobenzoylformic acid;4-Nitrobenzoylformic acid;4-NITROPHENYLGLYOXYLIC ACID;4-nitrophenylglyoxilic acid;(4-Nitrophenyl)(oxo)acetic acid;4-Nitro-a-oxobenzeneacetic acid;2-(4-Nitrophenyl)glyoxylic acid
- CBNumber
- CB9260458
- Molecular Formula
- C8H5NO5
- Formula Weight
- 195.13
- MOL File
- 14922-36-2.mol
4-NITROPHENYLGLYOXYLIC ACID Property
- Melting point:
- 113-115°C
- Boiling point:
- 381.6±34.0 °C(Predicted)
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 1.72±0.54(Predicted)
- form
- powder
- color
- Yellow
- BRN
- 1213023
- InChI
- InChI=1S/C8H5NO5/c10-7(8(11)12)5-1-3-6(4-2-5)9(13)14/h1-4H,(H,11,12)
- InChIKey
- RREPYIWLDJQENS-UHFFFAOYSA-N
- SMILES
- C(=O)(C(=O)O)C1=CC=C([N+]([O-])=O)C=C1
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2921490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CS-W004972
- Product name
- 2-(4-Nitrophenyl)-2-oxoaceticacid
- Purity
- 99.82%
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-W004972
- Product name
- 2-(4-Nitrophenyl)-2-oxoaceticacid
- Purity
- 99.82%
- Packaging
- 1g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 4654-1-3C
- Product name
- 2-(4-Nitrophenyl)-2-oxoacetic acid
- Packaging
- 1g
- Price
- $288
- Updated
- 2021/12/16
- Product number
- CHM0012160
- Product name
- 4-NITROPHENYLGLYOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $675.51
- Updated
- 2021/12/16
- Product number
- 4654-1-3C
- Product name
- 2-(4-Nitrophenyl)-2-oxoacetic acid
- Packaging
- 5G
- Price
- $912
- Updated
- 2021/12/16
4-NITROPHENYLGLYOXYLIC ACID Chemical Properties,Usage,Production
Uses
4-Nitrophenylglyoxylic acid (CAS# 14922-36-2) is a useful research chemical compound for organic synthesis and other chemical processes.
Synthesis
100-19-6
14922-36-2
General procedure for the synthesis of 2-(4-nitrophenyl)-2-oxoacetic acid from p-nitroacetophenone: Selenium dioxide (SeO2, 0.167 g, 1.5 mmol) and p-nitroacetophenone (0.165 g, 1 mmol) were added to a 25 mL round-bottomed flask under nitrogen protection. 10 mL of anhydrous pyridine was added and the reaction mixture was heated to 110 °C in an oil bath and refluxed with stirring. After 1 h of reaction, the reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature and allowed to stand for 4 hours. The precipitate containing SeO2 was removed by filtration through a Brinell funnel and the residue was washed with 50 mL of ethyl acetate. The filtrates were combined and treated with 1 mmol/L hydrochloric acid (20 mL). The aqueous layer was extracted three times with ethyl acetate (50 mL) to obtain aqueous layer 2 and organic layer 2, respectively. organic layer 2 was combined and extracted three times with 25 mL of water to obtain organic layer 3 and aqueous layer 3. aqueous layer 3 was treated with 1 mmol/L NaOH (50 mL) to obtain the reaction solution. The filtrate 4 was diluted and combined into the aqueous layer 2, and the pH was adjusted to 1.5 with 1 mmol/L hydrochloric acid.The mixture was extracted with ethyl acetate (3 × 50 mL). The organic layer was dried overnight in a vacuum desiccator to give the product 4-nitrophenylglyoxalic acid in a yield of 0.154 g in 79.2% yield.
References
[1] Synthetic Communications, 2008, vol. 38, # 24, p. 4434 - 4444
[2] Patent: CN108623611, 2018, A. Location in patent: Paragraph 0041; 0043; 0044; 0045; 0046
[3] Journal of Organic Chemistry, 2018, vol. 83, # 3, p. 1422 - 1430
[4] Journal of the American Chemical Society, 2010, vol. 132, # 34, p. 11898 - 11899
[5] Chemical Communications, 2013, vol. 49, # 35, p. 3640 - 3642
4-NITROPHENYLGLYOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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