2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE

Product Name: 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE
CAS No.: 64611-67-2
Chemical Name: 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE
Synonyms: 2-Hydroxy-4'-nitroacetophenone;2-Hydroxy-1-(4-nitrophenyl)ethanone;Ethanone, 2-hydroxy-1-(4-nitrophenyl)-;2-hydroxy-1-(4-nitrophenyl)ethan-1-one;2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE
CBNumber: CB7116386
Molecular Formula: C8H7NO4
Formula Weight: 181.15
MOL File: 64611-67-2.mol

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2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE Property

Melting point:: 140-143°C
Boiling point:: 338.4±17.0 °C(Predicted)
Density: 1.390±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 12.42±0.10(Predicted)
form: solid
InChI: InChI=1S/C8H7NO4/c10-5-8(11)6-1-3-7(4-2-6)9(12)13/h1-4,10H,5H2
InChIKey: DRGHCHSDUDQWHJ-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C([N+]([O-])=O)C=C1)CO

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: KOB0089
Product name: 2-Hydroxy-1-(4-nitrophenyl)-1-ethanone
Packaging: 1g
Price: $259
Updated: 2025/07/31

TRC

Product number: B446823
Product name: 2-hydroxy-1-(4-nitrophenyl)ethanone
Packaging: 500mg
Price: $310
Updated: 2021/12/16

Matrix Scientific

Product number: 045144
Product name: 2-Hydroxy-1-(4-nitrophenyl)-1-ethanone
Purity: >95%
Packaging: 5g
Price: $500
Updated: 2021/12/16

AK Scientific

Product number: 7360AE
Product name: 2-Hydroxy-1-(4-nitrophenyl)-1-ethanone
Packaging: 1g
Price: $205
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0020932
Product name: 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE
Purity: 95.00%
Packaging: 1G
Price: $722.8
Updated: 2021/12/16

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2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE Chemical Properties,Usage,Production

Synthesis

99-81-0

64611-67-2

Example 13A Synthesis of 2-hydroxy-1-(4-nitrophenyl)ethanone: 2-bromo-1-(4-nitrophenyl)ethanone (5 g, 20.5 mmol) and silver nitrate (5 g, 29.4 mmol) were dissolved in a solvent mixture of water (250 mL) and acetone (150 mL) and heated to reflux the reaction for 4 hours. After the reaction was completed, it was cooled to room temperature. The reaction mixture was filtered and the filtrate was extracted twice with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated. The concentrate was purified by silica gel fast column chromatography with 2:1 hexane/ethyl acetate as eluent to give 3.7 g (50% yield) of the target product 2-hydroxy-1-(4-nitrophenyl)ethanone. Thin layer chromatography (TLC) showed an Rf value of 0.4 (eluent ratio 1:1 hexane/ethyl acetate).

References

[1] Advanced Synthesis and Catalysis, 2016, vol. 358, # 1, p. 74 - 80
[2] Journal of Organic Chemistry, 1989, vol. 54, # 18, p. 4473 - 4474
[3] European Journal of Medicinal Chemistry, 2013, vol. 67, p. 142 - 151
[4] Patent: US2003/225098, 2003, A1. Location in patent: Page 32
[5] Chemische Berichte, 1889, vol. 22, p. 203

2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE Suppliers

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64611-67-2, 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONERelated Search:

4-NITROPHENYLGLYOXYLIC ACID ETHYL 4-NITROPHENYLGLYOXYLATE 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE SALOR-INT L207349-1EA SALOR-INT L207446-1EA SALOR-INT L345571-1EA SALOR-INT L207462-1EA SALOR-INT L204277-1EA SALOR-INT L207136-1EA SALOR-INT L345504-1EA SALOR-INT L207535-1EA SALOR-INT L207527-1EA SALOR-INT L204218-1EA SALOR-INT L207268-1EA SALOR-INT L204374-1EA SALOR-INT L207187-1EA SALOR-INT L207063-1EA SALOR-INT L204307-1EA

2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE

2-hydroxy-1-(4-nitrophenyl)ethan-1-one

Ethanone, 2-hydroxy-1-(4-nitrophenyl)-

2-Hydroxy-1-(4-nitrophenyl)ethanone

2-Hydroxy-4'-nitroacetophenone

64611-67-2